Acute promyelocytic leukemia (APL) represents 10 to 15 percent of the cases of acute myeloid leukemia in adults. This disease is characterized by a specific cytogenetic abnormality — reciprocal chromosomal translocations that disrupt the retinoic acid ...

By the end of the 1980s, there was strong epidemiologic evidence of a continuous association between plasma cholesterol levels and the risk of coronary heart disease (CHD).¹–³ Most patients with CHD have cholesterol levels that are not markedly elevated.⁴ ...

The recently described human herpesvirus 8 (HHV-8, also known as Kaposi's sarcoma–associated herpesvirus) can be detected in all forms of Kaposi's sarcoma.¹–⁴ HHV-8 infection, identified by the presence of HHV-8 DNA sequences in peripheral-blood ...

Cardiovascular disorders (stroke and ischemic heart disease) are an important cause of morbidity and mortality in the general population and in patients with end-stage renal disease treated with dialysis.¹–⁵ Hypertension is a major risk factor for ...

Implantable cardioverter–defibrillators have an important role in the treatment of patients with ventricular arrhythmias. Electromagnetic interference with permanent pacemakers and implantable defibrillators may have deleterious effects.¹–¹¹ Electronic ...

Figure 1. A genetically engineered, humanized antibody against CD25 (Tac, the interleukin-2–receptor α chain) was labeled with indium-111 and administered to a patient with CD25+ B-cell lymphoblastic leukemia at a dose of 1 mg per kilogram of body weight. ...

The term “dyspepsia,” derived from the Greek words dys (bad) and pepsis (digestion), refers to symptoms thought to originate in the upper gastrointestinal tract.¹,² Dyspepsia is often used to refer to upper abdominal pain or discomfort but may also ...

Stage

An 82-year-old woman was brought to the emergency department by her daughters because of deterioration in her mental capabilities over a period of three months. She had become increasingly forgetful and occasionally got lost in her own neighborhood. ...

One of our gentlemen found time to say `How delicious!'” declares Aunt Abby to a mortified Mortimer after he discovers a corpse in the 1944 movie classic Arsenic and Old Lace. The film's portrayal of rapid death after drinking arsenic-spiked elderberry ...

In this issue of the Journal, Regamey et al.¹ provide evidence that human herpesvirus 8 (HHV-8) can be transmitted through a kidney transplant. Physicians must be ever aware of new hazards of transplantation. This is the latest entry in a large and ...

To the Editor: The acoustomagnetic electronic article surveillance system is one of several types of antishoplifting gates that are now ubiquitous at the exits of retail stores. These systems emit a magnetic field that can interfere with cardiac ...

To the Editor: Glasier and Baird (July 2 issue)¹ found that emergency contraception was used responsibly by women who were given the appropriate medication to keep at home. Making emergency contraception available in this way is consistent with the ...

To the Editor: The report by Boden et al. (June 18 issue)¹ on the outcomes of patients with acute non–Q-wave myocardial infarction (the Veterans Affairs Non–Q-Wave Infarction Strategies in Hospital [VANQWISH] trial) is a welcome and important addition to ...

To the Editor: Link et al. (June 18 issue)¹ developed an animal model of commotio cordis. Ventricular fibrillation was reproducibly and instantaneously initiated by impacts to the chest during a narrow temporal window on the upstroke of the T wave in ...

To the Editor: Salama and Pusey (June 25 issue)¹ elegantly illustrate the renal findings in a 16-year-old girl with tuberous sclerosis, bilateral renal angiomyolipomas, and spontaneous right renal hemorrhage. She underwent a right nephrectomy. ...

To the Editor: Troglitazone is an antidiabetic drug that decreases hyperglycemia by increasing the sensitivity of peripheral tissue to insulin.¹ Its most serious adverse effect is hepatic dysfunction, which occurs in a small percentage of patients.² We ...

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Few topics in the 1990s have generated as much interest or controversy as sex bias and sexual harassment. Frances K. Conley's book, Walking Out on the Boys, is likely to do both. A few months before the Senate hearing on Clarence Thomas's nomination to ...

The field of the cerebral vascular diseases was relatively static for many years, but in this “Decade of the Brain,” the pace of discovery has rapidly increased. The editors of this textbook have attempted to provide an authoritative compendium and ...

This is an extraordinary book. Oxford University Press had the good judgment to reprint 45 commentaries William Silverman wrote for the quarterly Paediatric and Perinatal Epidemiology during the 10 years since its inception in 1987. Thirty-nine have been ...

Who will care for us when we are old? The overwhelming majority of older adults will continue to be served by generalist physicians who will be responsible for recognizing and managing geriatric health problems in various settings in collaboration with ...

Inhibition of the Adherence of P-Fimbriated Escherichia coli to Uroepithelial-Cell Surfaces by Proanthocyanidin Extracts from Cranberries Correspondence, N Engl J Med 1998:339;1085-1086.. The research described in this letter to the editor was supported ...