The relation between the treatment of hyperthyroidism due to Graves' disease and the course of Graves' ophthalmopathy is a matter of controversy.¹ Antithyroid-drug treatment appears not to be associated with the development or worsening of preexisting eye ...

During the past decade evidence has accumulated that increased factor VII activity represents a risk factor for ischemic cardiovascular disease.¹–³ The Northwick Park Heart Study group reported that high levels of factor VII were independently associated ...

Patients with clinically apparent coronary artery disease are at high risk for recurrent cardiovascular events. Efforts to prevent such events often involve cholesterol-lowering therapy, which has been demonstrated to reduce total mortality significantly ...

The benefits of low-intensity activity in reducing the risk of cardiovascular disease and increasing longevity have not been clearly identified.¹–⁶ Even less is known about the effects of such activities in older people. We undertook this study to examine ...

Figure 1. A 67-year-old man with difficulty walking and recent constipation, nocturia, and anorexia was found to have wasting of his legs and a firm, enlarged prostate. A chest radiograph, lateral view (Panel A), showed sclerosis of the entire T7 ...

The safety of calcium-channel antagonists in the treatment of cardiovascular disorders has recently become a controversial issue. A case–control study suggested a possible association between the use of calcium-channel antagonists to treat hypertension ...

Adverse Consequences of Severe Alkalemia

Severe alkalemia (blood pH greater than 7.60) can compromise cerebral and myocardial perfusion by causing arteriolar constriction, an effect that is more pronounced in respiratory than in metabolic alkalosis (Table ...

Presentation of Case

An 11-year-old right-handed boy was admitted to the hospital because of a seizure.

The child had been well until the day of admission, when he stood up and fell, striking his head on a desk. He became unconscious, with arms extended ...

Graves' ophthalmopathy and Graves' hyperthyroidism are closely linked, but the precise relation between these different expressions of the same disease is poorly understood. One much-debated issue is whether ophthalmopathy develops or becomes more severe ...

By the time the Beagle left the waters of the remote Galapagos Islands, Charles Darwin had still not realized that the natural variations within a species would provide the means for its evolution. Later, the Galapagos finches furnished ideal support for ...

Geneticists who study yeast, worms, and fruit flies have long recognized that an effective way to identify genes with functional relevance to a particular biologic process is to screen large numbers of mutagenized organisms. Researchers have recently used ...

To the Editor: We need to move beyond simplistic concepts such as the idea that low-density lipoprotein (LDL) cholesterol is “bad” and high-density lipoprotein (HDL) cholesterol is “good.” A low HDL level in a person consuming a diet that is low in fat, ...

To the Editor: The Efficacy and Safety of Subcutaneous Enoxaparin in Non–Q-Wave Coronary Events (ESSENCE) study (Aug. 14 issue),¹ in which a low-molecular-weight heparin was found to be more effective than unfractionated heparin in reducing the incidence ...

To the Editor: Hsu et al. (Sept. 4 issue)¹ describe a method of regional anticoagulation for continuous venovenous hemofiltration that involves the infusion of a citrate-containing replacement fluid. For over a year we have used a similar technique, in ...

To the Editor: We enjoyed the excellent and timely review of injury prevention by Rivara et al. (Aug. 21 and Aug. 28 issues).¹ We wish to comment on the role of automobile speeds and speed limits in increasing the toll of death and injuries in motor ...

To the Editor: The development of intraabdominal abscesses secondary to the ingestion of foreign bodies is a known but infrequent phenomenon.¹ We describe a patient with a right subphrenic abscess that developed after the accidental ingestion of a ...

In 1928, Thomas Rivers edited an authoritative book entitled Filterable Viruses (Baltimore: Williams and Wilkins) that summarized virologic knowledge of the time. Leading virologists who contributed chapters included Alexis Carrel (tissue culture), Edmund ...

Cryptosporidium has risen from obscurity to substantial public health importance within the past 15 years. This is the second edition of this authoritative textbook and reference guide for information on cryptosporidium.

Cryptosporidium is an enigmatic ...

This comprehensive, highly readable, multiauthored book is a fitting prelude to the “genomic era” of the staphylococcus that is upon us. The complete genomic sequence of the Staphylococcus aureus 8325 chromosome (approximately 2.8 Mbp) has been elucidated ...

This textbook, one of a series on neurologic diseases, is a multiauthored compendium intended for clinicians who diagnose and treat central nervous system infections. It is easy to be dismissive of such an effort, given the rapidity of recent advances in ...

Case Records of the Massachusetts General Hospital (Case 31-1997) Case Records of the Massachusetts General Hospital, N Engl J Med 1997:337;1065-1074.. On page 1068, the sentence that begins three lines from the bottom of the right-hand column should have ...

Effect of Inhaled Formoterol and Budesonide on Exacerbations of Asthma Original Article, N Engl J Med 1997:337;1405-1411.. On page 1408, the sentence that begins in line seven of the left-hand column should have read, “The combination of formoterol and ...