Right ventricular infarction is common in patients with acute inferior–posterior left ventricular myocardial infarction and may depress right ventricular function, resulting in right-heart failure and low cardiac output.¹–⁷ Despite the potentially life-...

Right ventricular infarction results from occlusion of the right coronary artery proximal to the marginal branches that perfuse the anterior wall of the right ventricle.¹,² However, the anterior free wall of the right ventricle is involved less frequently ...

Among persons infected with the human immunodeficiency virus (HIV), the disproportionate incidence of Kaposi's sarcoma among homosexual or bisexual men has long suggested that a sexually transmitted cofactor, in addition to background HIV infection, is ...

Approximately 2.5 million pregnant women now undergo screening of serum for Down's syndrome each year in the United States.¹ Nearly all this testing is carried out in the second trimester. The first serum marker found to be associated with Down's syndrome ...

Chronic myeloid leukemia can be cured only by hematopoietic stem-cell transplantation.¹,² Until recently this option was largely limited to patients with an HLA-identical sibling. The advent of national registries has made it possible to identify HLA-...

Figure 1. Panel A shows a leukemic infiltrate in the skin of a 62-year-old patient with acute myelogenous leukemia (subtype M2 according to the French–American–British system of classification). Chloromas usually present as reddish-blue, not green, ...

A patient in status epilepticus has continuous or rapidly repeating seizures. Although the danger of this pattern of seizure activity has been recognized since antiquity, our understanding of the pathophysiology of status epilepticus is incomplete. The ...

Hemodynamically important right ventricular myocardial infarction is an infrequent consequence of inferior myocardial infarction.¹ The clinical triad of hypotension, clear lung fields, and elevated jugular venous pressure occurs in less than 10 percent of ...

Transplantation of marrow from an unrelated donor offers the possibility of a cure for the 70 percent of patients with chronic myeloid leukemia (CML) who can tolerate the procedure and for whom a related donor is unavailable.¹ The probability of finding ...

The era of “scorecard” cardiovascular medicine has arrived.¹ New York was a pioneer in this field with its annual reports on mortality rates among patients undergoing coronary bypass surgery performed by various providers. In Pennsylvania, Colorado, and ...

To the Editor: Hunter et al. (Oct. 30 issue)¹ report that there is no significant correlation between breast cancer and plasma levels of 1,1'-dichloro-2,2-bis( p-chlorophenyl)ethylene (p,p'-DDE) and polychlorinated biphenyls (PCBs) two to three years ...

To the Editor: TNP-470 is a new inhibitor of angiogenesis that has shown potent antitumor activity in preclinical studies.¹–⁴ We performed a phase 1 study of this drug in patients with advanced squamous-cell carcinoma of the uterine cervix.⁵ One of the ...

To the Editor: Babior and Matzner (Nov. 20 issue)¹ state that the recently identified familial Mediterranean fever (FMF) gene²,³ can be used to establish the diagnosis of this disease. However, the penetrance of the four described mutations is not known, ...

To the Editor: Familial Mediterranean fever is an autosomal recessive disorder characterized by acute attacks of fever and inflammation of serous tissues. The disease affects certain ethnic groups, mainly Sephardic Jews, Armenians, Turks, and Arabs.¹ ...

To the Editor: The review of small-vessel vasculitis by Jennette and Falk (Nov. 20 issue)¹ is an excellent synopsis of the current understanding of these conditions.

The current debate about the causes and classification of polyarteritis and polyangiitis ...

To the Editor: The article by Toh et al. (Nov. 13 issue) ¹ on pernicious anemia includes a discussion of the neurologic complications of this disorder. The authors ignore a major point, which is that the neurologic manifestations of vitamin B₁₂ ...

To the Editor: In her review of the Nuremberg Doctors' Trial and its legacy (Nov. 13 issue),¹ Dr. Shuster devotes considerable space to an attempt by the Nazi defendants to equate experiments on inmates of concentration camps with American research on ...

It is sometimes useful to remind oneself of the rapidity with which social change now occurs. Thirty years ago, at the beginning of the modern era of bioethics, the central issue was whether patients had the freedom to refuse the life-sustaining ...

Asthma has become a major focus of health care and research. The prevalence of asthma has risen dramatically over the past 20 years, and the bewildering diversity of hypotheses to explain this epidemic illustrates our lack of understanding. There are ...

Obesity, the stepchild of American medicine, may be the only remaining medical condition in which patients are stigmatized and their physicians disparaged. Few members of the medical profession profess to treat obesity, and many of those who do are ...

Efficacy of the Rhesus Rotavirus–Based Quadrivalent Vaccine in Infants and Young Children in Venezuela Original Article, N Engl J Med 1997:337;1181-1187.. On page 1185, the footnotes to Table 3 should have read as follows:

Also in Table 3, in the third ...

During the past 15 years, the U.S. health care system has undergone breathtaking changes. It is no exaggeration to call this process a revolution. Authority was wrested from physicians and hospitals and conferred on health maintenance organizations (HMOs) ...