Prophylaxis with low-dose aspirin has been recommended to prevent preeclampsia, the rationale being that hypertension and abnormalities of coagulation in this disease are caused in part by an imbalance between vasodilating and vasoconstricting ...

During the past decade, malassezia species have emerged as increasingly important pathogens in neonates in intensive care nurseries. These organisms are lipophilic and have been associated with bloodstream infections in low-birth-weight neonates receiving ...

Hyperthyroidism is common, with a prevalence of approximately 2 percent in women and 0.2 percent in men.¹ It has widespread effects, among which those on the cardiovascular system are often prominent. Hyperthyroidism results in an increase in the heart ...

Nonsteroidal antiinflammatory drugs (NSAIDs) are commonly used to treat pain and inflammation.¹ Their use is frequently limited by gastrointestinal side effects, ranging from dyspeptic symptoms to life-threatening bleeding or perforation of gastroduodenal ...

Nonsteroidal antiinflammatory drugs (NSAIDs) are widely used¹,² but have substantial gastroduodenal toxicity and account for 21 to 25 percent of reported adverse reactions in patients taking these drugs in combination with other medications.³,⁴ ...

Figure 1. A 23-year-old brick mason presented with a three-month history of a boggy, crusted nodule on his upper lip (Panel A). Areas of alopecia and pustules were noted within the lesion. The man owned a bull mastiff, which also had alopecia on his snout ...

Osteoporosis affects an estimated 75 million people in Europe, the United States, and Japan.¹ It is a preventable and treatable condition, yet many people with osteoporosis remain unrecognized and untreated. The purpose of this review is to consider the ...

Presentation of Case

A 41-year-old man was admitted to the hospital because of leg weakness and mediastinal lymphadenopathy.

The patient had been well until a month earlier, when he fell while walking and felt weakness in the left leg. On the next day, he ...

Preeclampsia, defined as hypertension and proteinuria or nondependent edema after 20 weeks' gestation, is a common complication of pregnancy. Endothelial-cell dysfunction with vasospasm, pathologic coagulation, and hypersensitivity to pressor substances ...

There are hundreds of diseases known as zoonoses that are transmissible from lower vertebrates such as fish, birds, and other animals to humans. The many modes of transmission include direct contact (e.g., Microsporum canis infection), scratch (cat ...

To the Editor: The study by Schmidt et al. (Nov. 6 issue)¹ describes color duplex ultrasonography as a highly specific and noninvasive diagnostic test for temporal arteritis. Although ultrasonography appears promising, the authors' conclusions about its ...

To the Editor: Treatment of acute stroke seems to be controversial, as the Clinical Debate between Caplan et al. and Grotta (Oct. 30 issue)¹,² shows. Caplan and colleagues, on the con side, and Grotta, on the pro side, all stand firmly on the same side ...

To the Editor: Marafioti et al. (Aug. 14 issue)¹ report on monoclonal populations of lymphocytic and histiocytic (L&H) cells harboring somatically mutated genes of the antibody V _H region in 11 cases of lymphocyte-predominant Hodgkin's disease. On the ...

To the Editor: As Arcasoy and Jett (Nov. 6 issue)¹ suggest in their excellent review of Pancoast's syndrome, patients may present with supraclavicular lymph-node enlargement. The authors did not mention one shortcut to the diagnosis of this type of ...

To the Editor: Chromium compounds are commonly used as oxidizing agents in industrial processes and in technical-research laboratories. Oral ingestion of potassium dichromate usually leads to rapid death, regardless of immediate treatment attempts.¹ ...

To the Editor: I recently admitted two patients to the hospital for palliative care. Reimbursement was rejected by the insurance company for the care of one patient and is under review for the second patient. The outcome was unexpected in that both ...

To the Editor: The commentary in the Clinical Problem-Solving article “High on the Differential” (Nov. 6 issue) ¹ contains a misconception that, in my mind, illustrates very nicely why expert systems may sometimes lead to erroneous calculations of the ...

The system of health care for the poor in New York City is unique among U.S. cities both because of the size of the poor population and because of the city's commitment through most of this century to provide health care to those who cannot afford it. Two ...

Over a century ago, the active ingredient in the coca leaf was purified, and the first cases of cocaine dependence were described in North America and Western Europe. Overlooked for many years, cocaine resurfaced as a public health problem in the 1980s. ...

In an increasingly technological world, humans are attracted to the outdoors, “organic” foods, and weekend forays for exotic mushrooms. They are thus exposed to snake venom, botulism, and deadly hepatotoxins. As we seek political domination, the weapons ...