The prevalence of genital infection with herpes simplex virus (HSV) and its most serious complication, neonatal herpes, has increased during the past two decades.¹–⁶ Neonatal HSV infection most commonly results from contact between the newborn and either ...

The effect of risk factors such as high levels of serum cholesterol and high-density lipoprotein (HDL) cholesterol, high blood pressure, and cigarette smoking on the incidence of coronary disease in middle-aged people has been well described.¹–³ Less ...

Lactating women may require additional dietary calcium to compensate for the calcium secreted in breast milk, and the current recommended dietary allowance of calcium is increased by 400 mg per day in these women.¹ This recommendation assumes that calcium ...

Combination chemotherapy has improved the outcome of patients with intermediate-grade or high-grade non-Hodgkin's lymphoma (aggressive lymphoma).¹–⁵ Nevertheless, many patients do not have a complete remission or ultimately relapse. If such patients could ...

Figure 1. A 67-year-old man had a three-day history of pain, vesicles, and erythema of the right side of the forehead and frontal scalp, sharply demarcated at the midline. Material scraped from the floor of a vesicle was smeared on a slide and stained ...

Large randomized, controlled trials are generally considered the gold standard in evaluations of the efficacy of clinical interventions. However, since such trials are not always available, clinicians increasingly rely on meta-analysis to support their ...

Injuries are the most common cause of death among people 1 to 34 years of age, a leading cause of disability and years of life lost, and a major contributor to health care costs. There have been dramatic reductions in injury-associated mortality since the ...

Presentation of Case

A 64-year-old man was admitted to the Memory Disorders Clinic because of progressive dementia, seizures, and an unstable gait.

Nine years before admission he was noted to repeat questions after having received the answers. Five years ...

Nursing mothers provide an average of 200 to 250 mg of calcium per day to their infants, and as much as 400 mg per day.¹ Given that women absorb only about a third of the calcium they consume, the amount lost in breast milk represents a substantial ...

Meta-analysis has acquired a substantial following among both statisticians and clinicians. The technique was developed as a way to summarize the results of different research studies of related problems. Meta-analysis may be applied even when the studies ...

The Case for a Low-Fat, High-Carbohydrate Diet

The association between the dietary intake of fat and cholesterol and the extent of atherosclerosis and coronary heart disease has been recognized since 1907, when de Langen found little atherosclerosis in ...

To the Editor: The study by Taddio et al. (April 24 issue)¹ raises several troubling questions. First, if neonatal circumcision is not undertaken for medical reasons, is it ethical to conduct medical research on it? In the vast majority of cases, ...

To the Editor: Rabkin et al. (April 3 issue)¹ studied multiple biopsy specimens from eight patients with Kaposi's sarcoma and claim that Kaposi's sarcoma begins as a clonal disease at some specific site, circulates in the blood, and implants itself at ...

To the Editor: Sano et al. (April 24 issue)¹ conclude that alpha-tocopherol and selegiline are effective in slowing the progression of moderately severe Alzheimer's disease. Did they prove a true effect of treatment, or can the result be reasonably ...

To the Editor: Deceleration injury to the thoracic aorta due to high-speed motor vehicle collisions is a well-known phenomenon. Air bags have been shown to decrease the morbidity and mortality associated with high-speed injuries when used in conjunction ...

To the Editor: Reflex sympathetic dystrophy syndrome is commonly precipitated by trauma and is characterized by pain and swelling with signs of vasomotor instability in a distal extremity.¹ We describe a case of air-bag–induced trauma followed by the ...

To the Editor: Passenger-vehicle air bags are deployed by the rapid generation of a large volume of gas. This creates a brief (<100 msec), intense (150 to 170 dB) pressure wave that propagates through the passenger compartment.¹ The precise sound ...

To the Editor: We enjoyed the cautionary tale by Lynch and Rothstein (June 12 issue)¹ about a woman who accidentally ingested an insect while drinking a can of soda and was apparently stung in the throat. However, the endoscopic photograph of the bug in ...

In the last decade of the 15th century in Italy, there was an invasion by the French, recurrent bubonic plague, floods, famines, earthquakes, intemperate cold, and then a new disease, loathsome and incurable — the Great Pox, or French disease (Morbus ...

In his celebrated Microbe Hunters, published in 1926 (New York: Harcourt, Brace), bacteriologist-turned-novelist Paul de Kruif defined scientists who risk their lives by stalking deadly infectious agents as heroes. Colonel C.J. Peters would turn down the ...

In this ambitious book, which crosses national boundaries and major time periods, Krause, a professor of sociology at Northeastern University, wants us to reconsider professionalization as a cross-cultural phenomenon. His thesis is that the organized ...

The fourth edition of Ghadially's Ultrastructural Pathology of the Cell and Matrix is as beautiful as its three predecessors. One may even wonder whether the format of a coffee-table art book would not have made the book even more appealing, because the ...

Ion Channels — Basic Science and Clinical Disease Review Article, N Engl J Med 1997:336;1575-1586.. On page 1582, in Figure 5C, the label for the first gene defect should have read “LQT1 (11p15.5)” and for the third gene defect “LQT3 (3p21–24),” not “LQT1 ...

Case Records of the Massachusetts General Hospital (Case 23-1997) Case Records of the Massachusetts General Hospital, N Engl J Med 1997:337;260-267.. On the cover and on pages 265 and 266, Dr. Natowicz was mistakenly referred to as Dr. Nanowitz.