During the past decade there has been a resurgence of severe forms of disease caused by group A streptococci (Streptococcus pyogenes) in various parts of the world.¹ In the management of group A streptococcal infections, an important question is the ...

Antithrombotic therapy consisting of the intravenous infusion of unfractionated heparin plus oral aspirin represents the current standard of care for patients hospitalized with unstable angina or non–Q-wave myocardial infarction.¹–⁶ However, this ...

Lymphocyte-predominant Hodgkin's disease,¹–³ an indolent disorder associated with a long survival,⁴ represents approximately 5 percent of all cases of Hodgkin's disease.⁵ Its histopathological features include an obliterated lymph-node structure that ...

Nodular lymphocyte-predominant Hodgkin's disease, a subtype of Hodgkin's disease, is an indolent disorder in which tumors contain a variant of Reed–Sternberg cells known as lymphocytic and histiocytic (L&H) cells, which are admixed with small lymphocytes ...

Therapeutic interventions to prevent periventricular, intraventricular, and cerebral hemorrhages in preterm infants include the administration of drugs such as phenobarbital or indomethacin either before birth or immediately after delivery. Postnatal ...

Figure 1. A previously healthy three-year-old boy was brought to the emergency department with neck pain and intermittent fever of two days' duration, as well as a neck tilt and difficulty swallowing saliva. He had a temperature of 38.7°C and appeared ill,...

Hepatic encephalopathy is a complex neuropsychiatric syndrome that may occur in such diverse clinical situations as inherited errors of the urea cycle, acute or chronic liver disease, and spontaneous or iatrogenic portosystemic venous shunting, including ...

Presentation of Case

A 60-year-old man was admitted to the hospital because of a pulmonary infiltrate.

The patient had been well until 16 months earlier, when he was found to have a cervical soft-tissue mass, 3 cm by 3 cm by 2 cm, with an adjacent ...

The globalization of business, travel, and communication has brought increased attention to exchanges between farflung communities and countries. Similarly, awareness of the potential globalization of the bacterial ecosystem has led to a greater awareness ...

Unstable angina and non–Q-wave myocardial infarction together constitute a formidable medical problem. Remarkable recent advances in our understanding of the pathophysiology of acute coronary syndromes have, thus far, outpaced progress in developing novel ...

Reed–Sternberg cells and their variants have long held fascination for students of Hodgkin's disease. What are these cells, and how do they relate to the clinical manifestations of the lymphoma? Recent work indicates that they are clones of neoplastic B ...

Our primary concern is with the reliance on information ascertained from death certificates to determine the timing of death and the specific underlying cause. The rate of misclassification is high when this information is not supplemented with data from ...

To the Editor: In classic Hodgkin's disease, the characteristic Reed–Sternberg cells represent a minority of less than 1 percent of cells in affected tissue. The pathogenic role of these cells and their clonal nature have been matters of debate for a ...

To the Editor: Katz and Gerberding (April 10 issue)¹ raise questions about public health policy related to the costs of antiretroviral therapy given immediately after an exposure to the human immunodeficiency virus (HIV) to prevent seroconversion in ...

To the Editor: Recent advances in the treatment of human immunodeficiency virus (HIV) disease ¹ have raised considerable hope for people living with HIV, as well as for those at risk of infection.² These advances also pose potential new public health ...

To the Editor: The report by Stern et al. (April 10 issue)¹ of a cohort of 1380 patients with psoriasis who were treated with oral methoxsalen (psoralen) and ultraviolet A radiation (PUVA) suggests that PUVA therapy is associated with a higher incidence ...

To the Editor: Recent letters (April 17 issue)¹ regarding a magnetic resonance image (MRI) published in the October 31 issue inspired this letter. As a long-time reader of the Journal, I have, over the past two decades, observed what now seems to be a ...

The skin has a love–hate relationship with T cells. Usually, the liaison works well, protecting the body's outer sheath from invading organisms and incipient cancers. When it sours, the range of destructive autoreactive, inflammatory, and allergic ...

Strong theses make good books if the author undertakes the challenge with force and discipline. When the task at hand is not well executed, the reader is left with a sense of disappointment heightened by the sense of a promise unfulfilled. Such is the ...

Over the past 20 years, considerable advances have been made toward understanding the cause of rheumatoid arthritis, the mechanisms of joint destruction, the timing of events conducive to such an outcome, subgroups of patients with different possible ...

This book, the most comprehensive attempt to review the immunologic basis of renal disease, is long overdue, because it is more than 50 years since the immune basis of many renal diseases was established. The book is multiauthored and includes ...

Olfactory Dysfunction in Multiple Sclerosis Correspondence, N Engl J Med 1997:336;1918-1919.. On page 1919, the sentence that begins in line 19 of the left-hand column should have read, “Although numerous studies have reported olfactory dysfunction in ...

Valvular Heart Disease Review Article, N Engl J Med 1997:337;32-41.. On page 38, in Table 1, the heading for the second column should have read, “End-Systolic Dimension,” not “End-Diastolic Dimension,” as printed. We regret the error.