The high incidence of restenosis after balloon coronary angioplasty continues to limit the long-term success of the procedure.¹ Clinical trials of several pharmacologic agents have been conducted in an attempt to prevent restenosis, but none have been ...

Since the first successful transplantation of umbilical-cord blood in a patient with Fanconi's anemia,¹ cord blood has been used as a source of hematopoietic stem cells for transplantation to treat a variety of malignant and nonmalignant hematologic ...

High-dose oral corticosteroid therapy is given to patients with a variety of medical conditions. Although often effective, corticosteroids commonly cause osteoporosis.¹–³ The degree or extent of bone loss is most closely correlated with the cumulative ...

Since Escherichia coli O157:H7 was identified as an enteric pathogen in 1982, it has been the subject of multiple-outbreak and other epidemiologic investigations.¹ However, the molecular epidemiology and ecology of this organism in humans and animals ...

Figure 1. An 18-year-old woman presented three weeks post partum with a one-week history of headaches and two days of nausea, vomiting, and photophobia. On examination she was drowsy and had bilateral papilledema and a mild palsy of the right abducent ...

Obesity is the most common and costly nutritional problem in the United States, affecting approximately 33 percent of adults.¹ Health care costs directly attributable to obesity amount to approximately $68 billion per year, and an additional $30 billion ...

Epidemiologic studies have demonstrated an association between increased intake of antioxidant vitamins such as vitamin E and vitamin C and reduced morbidity and mortality from coronary artery disease. This association has been explained on the basis of ...

Respite gratifying immediate results, progressive narrowing of the coronary arteries over several months all too commonly limits the benefit of balloon angioplasty and various types of atherectomy. Even coronary-artery stents, which achieve a splendid ...

Glucocorticoid hormones have revolutionized the management of many illnesses, reducing morbidity in conditions such as rheumatoid arthritis and mortality in other diseases such as asthma. However, they have many side effects, one of the most troubling ...

To the Editor: Ridker and colleagues (April 3 issue)¹ have provided important new information that will be useful in assessing the risk of cardiovascular events and in optimizing prophylaxis. Both Ridker et al. and Maseri, in his editorial,² speculate ...

To the Editor: Brown et al. (April 10 issue)¹ summarize the main features of hepatitis-associated aplastic anemia and conclude that the hepatitis in patients with this disorder is not likely to be caused by any of the known hepatitis viruses, including ...

To the Editor: An important and unresolved problem is the treatment of patients with idiopathic thrombocytopenic purpura in whom severe thrombocytopenia persists despite splenectomy. In the June 2, 1994, issue, Andersen reported excellent results in 10 ...

To the Editor: I was disappointed by “A Common Clinical Conundrum” (April 3 issue).¹ This Clinical Problem-Solving article discussed a procedure — extracranial carotid-artery stenting — that is experimental, has not been validated by published ...

To the Editor: Several comments are in order for the U.S. audience of the excellent review of osteomyelitis by Lew and Waldvogel (April 3 issue),¹ especially regarding Table 2. Many infectious-disease specialists prescribe both penicillin and nafcillin ...

To the Editor: I report a case of cellulitis complicated by what turned out to be botfly larvae.

A 36-year-old woman presented with erythema, swelling, and pain in both shins. The lesions had developed two weeks after she returned from Peru. Cellulitis ...

Providers of medical care in the United States frequently regard the law with a mixture of suspicion and bewilderment. The suspicion is undoubtedly related, at least in part, to a fear of malpractice litigation that seems to influence physicians' behavior ...

In Ethics in Reproductive and Perinatal Medicine: A New Framework, Carson Strong promises to provide a new ethical framework for thinking about both policy and clinical issues in the field of reproductive and perinatal medicine, and he does just that. As ...

Venous thromboembolism and arterial thromboembolism are leading causes of morbidity and mortality in the developed countries. During the past two decades, there has been substantial progress in understanding the mechanisms of thromboembolism, in clinical ...

Information about much routine clinically oriented pharmacology can be found in specialty textbooks, but Goodman and Gilman's remains a cornerstone of clinical pharmacology whenever a thorough analysis is sought. This CD contains not only the full text ...

Inhaled Nitric Oxide in Full-Term and Nearly Full-Term Infants with Hypoxic Respiratory Failure Original Article, N Engl J Med 1997:336;597-604.. On page 602, the last paragraph in the right-hand column should have read, “There were no significant ...

Decision Analysis — Effects of Prophylactic Mastectomy and Oophorectomy on Life Expectancy among Women with BRCA1 or BRCA2 Mutations Special Report, N Engl J Med 1997:336;1465-1471.. On page 1468, in Figure 1, the key in all three panels should have read, ...

Marijuana is unique among illegal drugs in its political symbolism, its safety, and its wide use. More than 65 million Americans have tried marijuana, the use of which is not associated with increased mortality.¹ Since the federal government first tried ...