Endometriosis affects 2.5 to 3.3 percent of women of reproductive age¹ and is diagnosed in 20 to 68 percent of the women studied for infertility.²–⁵ The main visible features of the minimal and mild stages of endometriosis are peritoneal or ovarian ...

Chronic myelogenous leukemia has a poor outcome when treated with hydroxyurea or busulfan. These agents can control the disease, but they do not eliminate Philadelphia chromosome–positive stem cells from the bone marrow. Allogeneic bone marrow ...

Homocystinuria refers to a group of rare inborn errors of metabolism resulting in high levels of circulating homocysteine (>100 μmol per liter) and urinary homocysteine. A characteristic feature in patients with this condition is premature vascular ...

Invasive diagnostic or therapeutic procedures may be a route for the transmission of the hepatitis C virus (HCV).¹–⁵ In a study of patients in a gastrointestinal-disease unit, endoscopic biopsies were found to be an independent risk factor for HCV ...

Figure 1. A 24-year-old man was treated with high-dose cytarabine and idarubicin for relapsed acute myeloid leukemia. Ten days after beginning chemotherapy, the patient required nasal tamponade for heavy epistaxis. Three days later, tenderness over the ...

Approximately 95 percent of malignant tumors arising in the testis are germ-cell tumors, a term that indicates their origin in primordial germ cells. Germ-cell tumors also occasionally arise in extragonadal primary sites, and their management follows that ...

Until recently, there has been no consensus on the classification of or the diagnostic criteria for fungal sinusitis. Many case reports and series have lacked the histopathological data necessary to distinguish invasive from noninvasive disease, used ...

Presentation of Case

A newborn girl was admitted to the intensive care unit because of premature birth and congenital ascites.

The infant was born to a 27-year-old woman after a gestation of 28 weeks and 3 days. The pregnancy, which was the woman's first, ...

Endometriosis is defined as the presence of glandular and stromal endometrial tissue outside the uterus. It occurs most frequently in the reproductive organs, other pelvic viscera, and the peritoneum and is estimated to be present in 3 to 10 percent of ...

Chronic myeloid leukemia has fascinated hematologists and others for 150 years. It was probably the first form of leukemia to be recognized as an entity in its own right; and the discoveries in this century — first of the Philadelphia chromosome, and more ...

In 1992, the Department of Education tested 26,000 adults in the National Adult Literacy Survey to assess the literacy of the U.S. population in the English language.¹ On the basis of the survey results, it was estimated that 40 million to 44 million ...

To the Editor: We report the case of a 15-year-old boy with necrosis of the nasal septum due to aspergillus infection after autologous bone marrow transplantation for acute myelogenous leukemia. Treatment must often be initiated before a definitive ...

To the Editor: To the reports on hepatitis G virus (HGV) infection by H.J. Alter et al. and M.J. Alter et al. (March 13 issue),¹,² we can add some information concerning HGV RNA in the liver. Their studies were based on analyses of serum samples, and a ...

To the Editor: The article by Versaci et al. (March 20 issue)¹ reports more favorable clinical and angiographic outcomes for the treatment of isolated primary stenosis of the proximal left anterior descending coronary artery with stenting than with ...

To the Editor: In October 1995, a committee composed of members of the American Autonomic Society and members of the American Academy of Neurology met to develop consensus definitions of multiple-system atrophy (the Shy–Drager syndrome) and pure ...

To the Editor: Moreno et al. (March 20 issue)¹ describe a mild form of idiopathic biliary intrahepatic ductopenia in 24 asymptomatic adults who had persistently abnormal results on liver-function tests for at least one year. The authors state that liver ...

To the Editor: The effects of estrogen-replacement therapy on lipid metabolism — mainly, a reduction in levels of low-density lipoprotein (LDL) and modest increases in triglycerides and high-density lipoprotein (HDL) — have been well documented. However, ...

To the Editor: In Table 2 of his Special Report (March 20 issue),¹ Benatar compares the health care system in his country with that in the United States. Benatar shows the United States as having a ratio of specialists to family practitioners of 1:1. In ...

To the Editor: In 1966, Henry Beecher shocked the medical community when he documented the unethical research methods and practices used in many scientific studies published in U.S. medical journals after World War II.¹ Recently (March 20 issue), ...

To the Editor: I would like to expand on the brief allusion to “confidentiality certificates” in Bert Black's thoughtful Sounding Board article on subpoenas and science (March 6 issue).¹ Such federally issued certificates allow researchers to protect the ...

Justice and injustice are the twin leitmotifs that run through discussions of American prisons and jails. AIDS has merely heightened the negative consequences of self-deceiving correctional policies and further reduced the distance between “them” and “us.”...

The importance of the lung in the manifestations of HIV infection has been recognized from the time of the earliest cases. The first reports of the disease noted an increase in susceptibility to Pneumocystis carinii, one of the unusual infectious ...

Viruses were first identified as causative agents of disease in the late 19th century, and by the summer of 1939, research had progressed to such a point that the first symposium on viruses related to infectious disease could be held at the Harvard School ...

Students of anatomy will enjoy McMinn's Interactive Clinical Anatomy. This software transforms McMinn's color Atlas of Human Anatomy into a CD-ROM with added features. The illustrations are taken from the dissection of a human body in the anatomy room and ...

A Clinical Trial Comparing Primary Coronary Angioplasty with Tissue Plasminogen Activator for Acute Myocardial Infarction Original Article, N Engl J Med 1997:336;1621-1628.. On page 1621, the sentence that begins in line 9 of the Results section of the ...