Deep-vein thrombosis is a common complication of total hip replacement, and a variety of methods to prevent it have been studied. The rationale for the use of a specific thrombin inhibitor such as recombinant hirudin (desirudin) stems from its direct ...

Temporal arteritis is sometimes diagnosed clinically, but a temporal-artery biopsy is generally recommended to confirm the diagnosis. The American College of Rheumatology requires three of the following five criteria to be met to establish the diagnosis: ...

Infection with the human immunodeficiency virus (HIV) is an important risk factor for human papillomavirus (HPV) infection and the development of HPV-associated lesions in the female genital tract. HPV DNA is 2 to 3 times as frequent in cervicovaginal-...

Epidermoid anal cancer is a rare neoplasm of the epithelium lining the anal canal and perianal skin. The incidence of epidermoid anal cancer has increased considerably in recent decades,¹–³ most notably among women, unmarried men, and persons living in or ...

Figure 1. A 53-year-old man was evaluated because of a one-month history of anisocoria and left-sided ptosis of 1 mm (Panel A). He had had pain and numbness of the left arm and decreased sweating on the left side of his face for the previous nine months. ...

Tthe end of every century it is customary to reflect on the events of the past hundred years and to look toward the future, and in this lecture I should like to do this for cardiovascular disease. This is also an especially opportune time to comment on ...

Pancoast's syndrome is a constellation of characteristic symptoms and signs that includes shoulder and arm pain along the distribution of the eighth cervical nerve trunk and first and second thoracic nerve trunks, Horner's syndrome, and weakness and ...

Stage

A 48-year-old man who had received three cadaveric renal transplants had a 10-day history of painless edema of the legs. He was not short of breath at rest but had had moderate dyspnea on exertion for a week.

Response

The edema may be hydrostatic in ...

Among patients undergoing elective hip replacement, the incidence of deep-vein thrombosis in the absence of prophylactic anticoagulation approaches 50 percent.¹,² Thrombus formation is multifocal, occurring principally in the surgically manipulated leg, ...

Giant-cell (temporal) arteritis is a disease of middle-aged and older persons and in some populations is the most frequent form of vasculitis. The prevalence may be as high as 1 in 500 among persons over the age of 50 years and even greater among those ...

Squamous-cell carcinoma of the cervix (cervical cancer) has long been known to have all the epidemiologic characteristics of a sexually transmitted infectious disease. Annually, there are about 500,000 new cases of cervical cancer worldwide, and most of ...

To the Editor: Lepirudin (Refludan) is a genetically engineered recombinant form of hirudin that is used for anticoagulation therapy in patients with heparin-induced thrombocytopenia due to heparin-dependent antiplatelet antibodies.¹ We report a case of ...

To the Editor: We are puzzled by inconsistencies in the association between hormone use and mortality described by Grodstein et al. (June 19 issue)¹ in the Nurses' Health Study. The authors reported that current hormone use (as compared with nonuse) was ...

To the Editor: The excellent review of imaging of the hepatobiliary tract by Saini (June 26 issue)¹ does not mention an important new combined radiologic and surgical method for the examination of the hepatobiliary tract — diagnostic laparoscopy combined ...

To the Editor: The International Forum for Transplant Ethics strongly supports paired kidney exchange, as proposed by Ross et al. (June 12 issue).¹ It is ethically acceptable and would allow more living-donor kidneys to be transplanted. There are ...

To the Editor: In their paper on neuroradiographic manifestations of eastern equine encephalitis, Deresiewicz et al. (June 26 issue)¹ report on the predilection of this disease for the basal ganglia, thalami, and brain stem. We would like to add another ...

To the Editor: In describing their comparison of the urinary trypsinogen-2 dipstick test and the serum amylase assay for the diagnosis of acute pancreatitis, Kemppainen et al. (June 19 issue)¹ mention the unsatisfactory sensitivity and specificity of ...

To the Editor: I was disturbed by the Sounding Board by Asch and Ubel on rationing (June 5 issue).¹ It was very one-sided, only describing episodes of rationing in which physicians withhold care. What about the flip side — when we overtreat patients for ...

To the Editor: I recently encountered a stunt pilot with an L4–5 herniated disk, documented by magnetic resonance imaging (MRI), who had sciatic pain and experienced exacerbation of symptoms when pulling out of a sharp dive, at which point his body was ...

John Riddle has established his reputation as a leading expert on ancient Greek pharmacology. In an earlier study, Contraception and Abortion from the Ancient World to the Renaissance (Cambridge, Mass.: Harvard University Press, 1992), he argued that a ...

A large number of low-birth-weight infants (less than 2500 g) are born in the United States each year, accounting for 6.9 percent of all live births. Approximately 50,000 of these are of very low birth weight (less than 1500 g). Advances in health care in ...

Within the past two decades an explosion of scientific information has besieged both the established researcher and the student. One field that has grown disproportionately over this period is genetics, which has evolved into a biochemical and molecular ...

Testicular Germ-Cell Cancer Review Article, N Engl J Med 1997:337;242-254.. On page 248, in Table 3, the values under the headings “International” and “Nonseminoma” for the intermediate-risk group were wrong. The corrected table appears below. We regret ...