Rotavirus diarrhea is a public health problem throughout the world, and it takes its greatest toll on infants and young children less than 24 months of age. Development of a rotavirus vaccine to prevent severe diarrhea is a high priority.¹,² Although ...

Esophageal cancer is an aggressive carcinoma with a poor prognosis. Although postoperative mortality has declined and rates of complete resection have improved considerably, reported rates of survival five years after surgery range from 20 to 36 percent.¹–...

Pharmacologic treatments such as nicotine-replacement therapy have been shown to help smokers stop smoking. Using a medication that does not contain nicotine, such as an antidepressant, has intrigued investigators for several reasons. Smokers are more ...

Fasting is accompanied by a decrease in the availability of glucose for energy use in peripheral tissues and, consequently, an increased reliance of these tissues on the availability of ketone bodies and fatty acids for energy. The availability of ketone ...

Figure 1. The hand of an infant girl who was born at 24 weeks of gestation and weighed 540 g (1 lb 3 oz) at birth is shown. The infant was found to have jejunal atresia on the sixth day of life and underwent a small-bowel resection with primary ...

During the past 40 years, epidemiologic research has elucidated many important associations between the sociodemographic characteristics of mothers and the birth weight of infants.¹–⁴ For example, the extremes of childbearing age,¹ cigarette smoking,² ...

Local Anesthetics

Local anesthetics can be administered by local or regional injection to provide anesthesia during surgery. Regional injection of local anesthetics is used for major nerve block and for spinal (subarachnoid) or epidural block. Although ...

Presentation of Case

A 75-year-old man was admitted to the hospital because of chest pain, hemoptysis, and a pulmonary lesion.

The patient had been well until four months earlier, when he began to have left-sided posterior pleuritic chest pain, which was ...

The development of the quadrivalent rotavirus vaccine evaluated in the study by Pérez-Schael et al., reported in this issue of the Journal, ¹ represents the culmination of a long and highly creative process of research and development at the National ...

Nicotine has been the mainstay of pharmacotherapy for tobacco addiction, but other medications, such as the antidepressant drugs bupropion and nortriptyline, are also effective. These antidepressant agents are effective in patients without current ...

In an article in this issue of the Journal, ¹ David and Collins examine the relation of race to birth weight among blacks and whites. Their laudable but difficult undertaking is welcome. Clearly, the human and economic toll exacted by poor pregnancy ...

The Supreme Court has unanimously ruled that there is no constitutional right to physician-assisted suicide.¹,² Unexpectedly, however, the Court did much more than simply uphold the New York and Washington statutes prohibiting assisted suicide. A Court ...

In rejecting a constitutional right to physician-assisted suicide earlier this year,¹,² the U.S. Supreme Court appeared to preserve the distinction between the withdrawal of life-sustaining treatment and assisted suicide or euthanasia. In fact, however, ...

To the Editor: Generally, I heartily agree with you (June 12 issue)¹ that legislators should not be practicing medicine. However, the issue of partial-birth abortion should not be mixed in with the others. The concern over this matter, as opposed to a ...

To the Editor: Carette et al. (June 5 issue)¹ studied the efficacy of epidural methylprednisolone injections in patients with sciatica due to a herniated nucleus pulposus. After three and six weeks, the patients who received injections of corticosteroid ...

To the Editor: Although antagonists of the platelet glycoprotein IIb/IIIa receptor are undoubtedly efficacious in selected patients undergoing angioplasty, we believe there is an alternative perspective to that of the Evaluation in PTCA to Improve Long-...

To the Editor: Ticlopidine hydrochloride (Ticlid) is a potent platelet-antiaggregating agent that has been used in the United States since 1991 to reduce the risk of thrombotic stroke in patients with aspirin intolerance. Recently, it has been ...

To the Editor: The use of DNA testing in forensics has been widely publicized. We used DNA testing to determine that a pathological diagnosis of cancer was based on extraneous tissue and thereby avoided unnecessary treatment. A 44-year-old woman ...

To the Editor: Dr. Magid and colleagues (June 12 issue)¹ provide interesting data on the correlates of delays in seeking treatment among patients with acute myocardial infarction. Because they studied only one health maintenance organization (HMO), the ...

To the Editor: Thanks to Dr. Stack (June 5 issue)¹ for the stunning photograph and description of the black widow spider. However, in my area, I usually encounter black widow spiders from the dorsum, not the ventrum, so the hourglass marking is not ...

Sex is a lot like consultants. It can be treacherous to live with but untenable to live without. Achieving the right balance of both is something, I suspect, that a great many health care executives struggle with. Consulting, not sex, is the focus of ...

For many physicians, the Little, Brown Spiral Manuals have eased the stress of their first days at a new internship or residency; the well-known “Washington” manual has been a friend in numerous near-panic situations throughout internship. Some of us ...

Renal medicine is largely a disappointing discipline for the practicing physician. Although dialysis and transplantation can nowadays successfully substitute for renal function when kidneys have failed, there are almost no effective treatments for chronic ...

Treatment of Venous Thrombosis with Intravenous Unfractionated Heparin Administered in the Hospital as Compared with Subcutaneous Low-Molecular-Weight Heparin Administered at Home Original Article, N Engl J Med 1996:334;682-687.. On page 683, in the left-...

Retropharyngeal Abscess Images in Clinical Medicine, N Engl J Med 1997:337;472.. In Panel A of the Image in Clinical Medicine, the small arrow indicating the normal epiglottis was misplaced. The epiglottis is seen arising 1 cm superior to the small arrow, ...