Herpes simplex virus type 2 (HSV-2) causes vesicular and ulcerative lesions in adults¹–³ and may cause severe systemic disease in neonates and immunosuppressed hosts.⁴–⁶ In addition, genital ulceration caused by HSV-2 may facilitate the transmission of ...

Hepatotoxicity due to overdoses of acetaminophen (also known as paracetamol) has become an important problem.¹,² Previous reports have defined two distinct clinical syndromes. When patients attempting suicide ingest large amounts of acetaminophen, acute ...

Recent trials have confirmed the importance of achieving early, complete, and sustained reperfusion after acute myocardial infarction.¹–³ In the Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded Coronary Arteries (GUSTO I) ...

Administration of 100 mg of alteplase (tissue plasminogen activator) over a period of 90 minutes has been shown to induce more rapid lysis of coronary-artery thrombi than a 3-hour infusion of the same dose.¹,² This accelerated rate of infusion (with ...

Figure 1. A painful finger ulcer (Panel A) developed in a 58-year-old man who was also found to have a palpable olecranal lymph node. The rest of his examination was unremarkable. A biopsy specimen of the lesion, fixed and sectioned thinly for ...

A century and a half after the first administration of ether, at the Massachusetts General Hospital in Boston, and almost 30 years since the last review of anesthesiology in the Journal, it is fitting to consider recent advances in the field.¹ In the late ...

Each year in the United States, more than 12 million traumatic wounds are treated in emergency departments.¹ When nonemergency or elective incisions are included, approximately 90 million skin-suturing procedures are performed each year.² Traumatic ...

Presentation of Case

A 43-year-old woman was admitted to the hospital in early June because of possible adult respiratory distress syndrome.

The patient had been in excellent health until nine days earlier, when she began to have low-grade fever, ...

In this issue of the Journal, Fleming and colleagues report that the age-adjusted seroprevalence of herpes simplex virus type 2 (HSV-2) in the United States is now 20.8 percent, an increase of approximately 30 percent over the 13 years between the second ...

In the typical two-group clinical trial with outcomes of either success or failure, investigators are interested in finding out whether an innovative treatment, T, reduces the frequency of failure relative to standard therapy, S. If p_T and p_S are used to ...

Reporting of patients with AIDS by name (AIDS surveillance) has until now formed the cornerstone of the nation's efforts to monitor and characterize the epidemic of human immunodeficiency virus (HIV) infection. AIDS surveillance tracked the growth of the ...

To the Editor: In the Global Use of Strategies to Open Occluded Coronary Arteries in Acute Coronary Syndromes (GUSTO IIb) substudy (June 5 issue),¹ although the outcomes at 30 days with primary percutaneous transluminal coronary angioplasty (PTCA) were ...

To the Editor: The meticulous epidemiologic investigation reported by Herwaldt et al. (May 29 issue) ¹ establishes the association between a large outbreak of cyclosporiasis in North America and the consumption of raspberries imported from Guatemala. The ...

To the Editor: Kaplan et al. (June 5 issue)¹ “recommend that low-dose chemotherapy be considered for most patients with HIV [human immunodeficiency virus] infection and non-Hodgkin's lymphoma,” but their results do not convincingly support a general ...

To the Editor: We wish to report on an unusual presentation of multiple myeloma. A 44-year-old man had a dry cough and slowly increasing dyspnea over four months. He smoked 20 cigarettes a day and had had asthma as a child. He presented after an acute ...

To the Editor: Ureteral obstruction is an infrequent but serious complication of pelvic endometriosis. Often, endometriosis is not identified as the cause of the obstruction before surgery. Hormonal therapy has been attempted,¹ but surgery remains the ...

To the Editor: The patient I described in an Image in Clinical Medicine (July 10 issue)¹ was described by others at this institution in the July issue of the American Journal of Respiratory and Critical Care Medicine. ² The duplication was inadvertent on ...

To the Editor: As coordinators of the national study of reproduction and children's health among Gulf War veterans in the United Kingdom, we were interested in the report by Cowan et al. (June 5 issue)¹ on birth defects in similarly deployed U.S. service ...

Each year 12 million new cases of sexually transmitted diseases, including 3 million in teenagers, occur in the United States, with population rates higher than in any other developed country. In 1995, 5 of the 10 most frequently reported diseases in the ...

In 1997, a total of 532 pages on the diagnosis, treatment, and prevention of viral hepatitis seems to make this book neither fish nor fowl. On one hand, 532 pages are insufficient for the adequate treatment of the literature on these subjects for ...

About 25 years ago, an irreverent wag used “lymphodrek” to refer to the mysterious factors released by cultured lymphocytes or macrophages that could activate, attract, or inhibit other mononuclear leukocytes. These enigmatic phenomena seemed to depend ...

Hepatitis-Associated Aplastic Anemia Correspondence, N Engl J Med 1997:337;424-425.. The journal cited in reference 4 of the letter by Kiem et al. is incorrect. The correct journal is Biology of Blood and Marrow Transplantation. We regret the error.