Acute promyelocytic leukemia is a distinct subtype of acute myeloid leukemia¹ in which a balanced reciprocal translocation between chromosomes 15 and 17 results in the union of portions of the promyelocytic leukemia gene with the gene for retinoic acid ...

Crohn's disease is a chronic inflammatory disorder characterized by patchy granulomatous inflammation of any part of the gastrointestinal tract.¹ Patients have a spectrum of clinical features, with great variation in the course of the disease. Mesalamine ...

Despite the introduction of several new medical therapies, patients with advanced Parkinson's disease continue to have fluctuations between pronounced increases in parkinsonism (“off” periods) and episodes of improved mobility (“on” periods), which are ...

Figure 1. A 65-year-old man had T-cell, large-cell non-Hodgkin's lymphoma of the right temporalis muscle with localized bone destruction. Computed tomography of the chest, abdomen, and pelvis showed no evidence of lymphoma. Bone marrow biopsy and analysis ...

Preventing people from beginning to smoke is a major public health priority.¹–³ Efforts must focus on the young, because 88 percent of smokers start by the age of 18³ and smoking is increasing among adolescents.⁴,⁵ Reducing young people's access to ...

Smoking is a major health hazard, and since nonsmokers are healthier than smokers, it seems only natural that not smoking would save money spent on health care. Yet in economic studies of health care it has been difficult to determine who uses more ...

Emergency postcoital contraception may be defined as the use of a drug or device to prevent pregnancy after intercourse. Unwanted pregnancy is common; worldwide, about 50 million pregnancies are terminated each year.¹ It has been calculated that each year ...

Presentation of Case

A 67-year-old man was admitted to the hospital because of fever and dyspnea.

The patient had a long history of insulin-dependent diabetes mellitus, hypertension, chronic renal failure, and coronary artery disease, culminating in the ...

Until recently, chemotherapy and hematopoietic stem-cell transplantation were the only therapeutic options in acute leukemia. The idea of restoring normal differentiation in primitive leukemic cells seemed unrealistic until the effect of all-trans-...

Unintended pregnancies are endemic in the United States, and the costs are huge.¹ The traditional approach to this problem has been primary prevention (contraception), backed up by secondary prevention (induced abortion). For decades, emergency ...

Despite recent advances in both medical and surgical therapies, dilated cardiomyopathy remains a leading cause of cardiovascular morbidity and mortality. This syndrome consists of ventricular enlargement, abnormal systolic and diastolic left ventricular ...

The fate of the proposed tobacco settlement and, in turn, the health and longevity of generations of Americans now lie in the hands of the Congress. The settlement is the product of intense negotiations among 40 state attorneys general, a coalition of ...

To the Editor: The editor of the New England Journal of Medicine is entitled to be a critic of managed care, but it is profoundly disturbing to see such an important and presumably dispassionate publication used as a sounding board for these critical ...

To the Editor: Jacobson et al. (May 22 issue)¹ report encouraging results in their placebo-controlled trial of thalidomide for aphthous ulceration in patients with human immunodeficiency virus (HIV) infection. However, potential enthusiasm must be muted ...

To the Editor: Law et al. (May 22 issue)¹ report that patients with idiopathic thrombocytopenic purpura who have poor responses to high-dose intravenous immune globulin are unlikely to have good or excellent responses to splenectomy. In our experience, ...

To the Editor: The study by Liem et al. (May 29 issue)¹ comparing laparoscopic surgery with conventional surgery for inguinal-hernia repair demonstrated an advantage of laparoscopic repair in terms of recurrences and recovery. However, only 3 percent of ...

To the Editor: The observation by Bishop et al. (May 29 issue)¹ regarding aluminum contamination of hyperalimentation solutions is interesting, but we would like to point out several limitations of the study design and analysis.

First, toxicity may be a ...

To the Editor: Although the opinions of pharmacists on euthanasia and physician-assisted suicide have been examined,¹ there is little information about their practices. Between April and September 1994, we surveyed attitudes and practices with respect to ...

Several studies have suggested that 5 percent of practicing physicians could be considered problem doctors. Although there is no agreed-on definition of “problem doctors,” it is a term that has been used to encompass a wide range of behavior, including ...

The medical profession — especially organizations like the American Medical Association and state medical societies — has taken a special interest in identifying and managing substance abuse among its members. However, as Robert Holman Coombs points out, ...

The impetus for this book grew out of the editors' concern that the behavioral and neuroscience disciplines have developed independently of one another; in research on drug abuse, therefore, a mutual understanding of each other's technology was in order. ...

The Relation of Virologic and Immunologic Markers to Clinical Outcomes after Nucleoside Therapy in HIV-Infected Adults with 200 to 500 CD4 Cells per Cubic Millimeter Original Article, N Engl J Med 1996:335;1091-1098.. On page 1094, Figure 1 is incorrect. ...

For Whom the Bell Tolls, Ernest Hemingway's novel about the Spanish Civil War, ends with its American hero, Robert Jordan, mortally wounded and trying to decide whether to commit suicide with a machine gun or risk capture by trying to retain consciousness ...