Infection with Mycobacterium tuberculosis is the most common human infection worldwide. As the epidemic of human immunodeficiency virus (HIV) infection continues to evolve, the risk of dual infection with HIV and M. tuberculosis may be substantial in ...

Schizophrenia is a chronic, disabling mental illness that affects approximately 1 percent of the U.S. population and costs $33 billion per year.¹,² Although conventional antipsychotic drugs have been the mainstay of treatment since the mid-1950s, only 70 ...

Atopic dermatitis, an inflammatory skin disease with a chronically relapsing course, is characterized by episodes of intense pruritus, lichenification, severely dry skin, and a susceptibility to cutaneous infections.¹–³ There is currently no safe ...

Peanuts are one of the commonest causes of food allergy in the United States and Europe.¹–³ They are also a leading cause of food-induced anaphylaxis and death, which usually follow inadvertent exposures.⁴,⁵ Allergy to peanuts is an IgE-mediated, mast-...

Myoglobin released during muscle injury can precipitate acute renal failure.¹,² There are many causes of rhabdomyolysis, including excessive exercise, “crush” injuries, seizures, infections, severe potassium and phosphate depletion, staphylococcal toxins, ...

Figure 1. A 22-year-old man with pseudoxanthoma elasticum and normal visual acuity was found to have bilateral angioid streaks. These vessel-like streaks (arrowheads) are breaks in Bruch's membrane beneath the retina. They can threaten vision if ...

Over the past 20 years, outpatient parenteral therapy with antimicrobial drugs has proved effective, safe, and cost effective for patients with a wide range of infectious diseases.¹–⁴ Teams to manage this type of therapy have been established at medical ...

Presentation of Case

A 54-year-old woman was admitted to the hospital because of pain and swelling of the right leg.

The patient was otherwise in good health except for non-insulin-dependent diabetes mellitus of five years' duration, which was regulated ...

An essential ethical condition for a randomized clinical trial comparing two treatments for a disease is that there be no good reason for thinking one is better than the other.¹,² Usually, investigators hope and even expect that the new treatment will be ...

The World Health Organization (WHO) estimated that by June 1996 14 million people were living with human immunodeficiency virus (HIV) infection in sub-Saharan Africa. Although it contains only 10 percent of the world's population, sub-Saharan Africa is ...

Although medications have dramatically improved the lives of many people with schizophrenia, treatment resistance remains a serious problem. Three quarters of patients with schizophrenia become ill before the age of 25. The manifestations of the disease ...

It has been almost three years since the Journal ¹ published the results of AIDS Clinical Trials Group (ACTG) Study 076, the first randomized, controlled trial in which an intervention was proved to reduce the incidence of human immunodeficiency virus (...

To the Editor: Your editorial on the American Medical Accreditation Program (AMAP) (July 3 issue)¹ was flawed both logically and factually. The American Medical Association (AMA) did not design AMAP as a “surrogate” for board certification. AMAP ...

To the Editor: Meaney et al. (May 15 issue)¹ describe encouraging results with the use of magnetic resonance angiography to confirm the diagnosis of pulmonary embolism. However, their inference that magnetic resonance angiography may provide a substitute ...

To the Editor: In the review of atrial arrhythmias after cardiac surgery by Ommen et al. (May 15 issue),¹ no mention is made of the use of parenteral magnesium sulfate. Hypomagnesemia is frequent after diuresis in patients who have undergone ...

To the Editor: In their letter (May 15 issue)¹ on minimally invasive coronary-artery byass surgery,² Friedrich and colleagues advocate what they call a “new approach to coronary revascularization,” in which revascularization of two-vessel disease is ...

To the Editor: In discussing Case 11-1997 (April 10 issue),¹ Sandrock directs attention to a “critical-illness myopathy associated with myosin deficiency.” This diagnosis is clearly based on, in addition to pathological muscle findings, the ...

To the Editor: Serum concentrations of leptin, a hormonal product of adipose tissue, correlate closely with body-mass index and adipose-tissue mass in adults¹ and children,² but these relations have not been studied in pregnant women and their neonates.

...

The editors of Cardiovascular Pharmacotherapeutics have endeavored to summarize the latest information on the mechanisms of action, pharmacokinetics, drug interactions, therapeutic efficacy, and direct application to patients of drug treatment for cardiac ...

Practical Management of Cardiac Arrhythmias, which is intended to offer “a concise, yet all-inclusive, review of the up-to-date strategies in the management of cardiac arrhythmias,” has three sections, each on a different aspect of therapy: pharmacologic ...

Arrhythmias are a common and often perplexing problem for physicians involved in the care of infants, children, and adolescents. Most arrhythmias in young patients are benign, but some may cause severe symptoms and even sudden death. In this era, as ...

Spodick's The Pericardium is not only first-rate but also humbling. Written with considerable literary craftsmanship, this book reaffirms that Spodick is one of our preeminent “pericardiologists.” Each richly detailed section reveals the breadth of the ...

Bone Mass and the Risk of Breast Cancer Correspondence, N Engl J Med 1997:337;199-200.. On page 200, the sentence that begins in line 20 of the right-hand column should have read, “The results are the same as our previous findings — that is, the relative ...