Hypoxic respiratory failure in neonates born at or near term (at >34 weeks' gestation) may be caused by conditions such as primary persistent pulmonary hypertension, respiratory distress syndrome, aspiration of meconium, pneumonia or sepsis, and ...

Infants with persistent pulmonary hypertension have severe cyanosis even when they breathe high concentrations of oxygen. Although the pulmonary hypertension can be associated with other conditions (such as aspiration of meconium and sepsis), it may be ...

High levels of estrogen are considered to be a risk factor for breast cancer,¹–³ but it has been difficult to assess this association. Measurement of estrogen levels in blood or urine poses many methodologic and logistic problems, including fluctuations ...

Muscle diseases (myopathies) are most often caused by inborn errors resulting in the degeneration of muscle fibers (muscular dystrophies). The muscular dystrophies are a clinically and genetically heterogeneous group of disorders. Clinically, many of the ...

Figure 1. A 65-year-old man presented with recurrent ventricular tachycardia. At cardiac catheterization a calcified structure (Panel A) was visible adjacent to the pigtail catheter. The structure was also visible on a chest film obtained 20 years earlier ...

With the increase in the number of high-speed motor vehicle accidents, blunt trauma has become a major health problem. Improvements in the techniques of transporting injured patients and in the care given outside the hospital have increased the number of ...

The insulin-like growth factors (IGFs) participate in the growth and function of almost every organ in the body.¹ Because of the wide range of their biologic effects and their therapeutic potential in a variety of clinical disorders, the IGFs have become ...

Presentation of Case

A 14-year-old girl was admitted to the hospital because of recurrent rectal bleeding.

She had been in excellent health until three years earlier, when she began to pass blood-tinged stools. The bleeding increased during the course of ...

The muscular dystrophies are characterized by variable degrees of muscle weakness and degeneration. Their classification has traditionally been based on the phenotype and mode of inheritance. The molecular genetic revolution has now helped clarify but has ...

Despite an ethical and legal consensus regarding the right of patients or their surrogates to refuse life-prolonging therapy, surveys show that dying patients in hospitals in the United States frequently receive unwanted interventions.¹,² One reason for ...

To the Editor: The high rate of cesarean section in developed countries is arguably the most important issue in modern obstetrics. We are therefore concerned that the study by McMahon et al. (Sept. 5 issue)¹ on delivery after a previous cesarean section ...

To the Editor: Leach et al. report (Sept. 12 issue)¹ that partial liquid ventilation with perfluorocarbons in premature infants may be an effective therapy for severe respiratory distress syndrome. Their conclusion that such treatment prevented oxygen ...

To the Editor: Drs. Jacobson and Jacobson (Sept. 12 issue)¹ reported that low-level exposure to polychlorinated biphenyls (PCBs) in utero is associated with lower IQ scores (by an average of 6.2 points) among school-age children. The results seem ...

To the Editor: Progressive multifocal leukoencephalopathy caused by JC papovavirus infection of glial cells is an increasingly frequent complication of human immunodeficiency virus (HIV) type 1 infection. To date, there is no treatment available for ...

To the Editor: In his article on the trend toward using “advance care planning” as a guise for limiting treatment (Sept. 5 issue),¹ Levinsky sounds many appropriate warnings. Advance planning is intended to ascertain and clarify “patient preferences,” ...

To the Editor: Callahan (Sept. 5 issue)¹ has again urged us to confront openly the challenge of providing decent health care to the elderly in a manner that is socially affordable. What his essay does not note is that we must also confront the fact that ...

To the Editor: In the report by Kittner et al. (Sept. 12 issue)¹ on pregnancy and the risk of stroke, the relative risk of stroke during the postpartum period was extremely high. During the years of the study, 1988 and 1991, bromocriptine mesylate (...

This textbook of pathology was written with the expressed objective of describing the fundamental processes of pathology in relation to the practice of medicine, especially as it pertains to patient care. To provide a full understanding of the subject, ...

At a time when our knowledge of genotypes is rapidly expanding, the publication of this book describing the rich and complex variation in phenotypes is refreshing. Written by a husband and wife, the book is seamless, flowing, and full of wonderful ...

The authors have presented a mass of up-to-date and pertinent information in a coherent, interesting, and easily assimilable form. The strength of this work lies in its in-depth reviews of three major topics: the consequences of vitamin A deficiency, ...

The appeal of this book lies in its concise presentation of information in a readable format with superb color photographs. The 85 chapters by 80 contributors are organized according to clinical patterns of dermatologic disease, such as eczematous, ...

The Effects of Preparations of Human Chorionic Gonadotropin on AIDS-Related Kaposi's Sarcoma Original Article, N Engl J Med 1996:335;1261-1267.. On page 1264, the sentence that begins in line 7 of the left-hand column should have read, “One patient had ...

Advances in Coronary Angioplasty Review Article, N Engl J Med 1996:335;1290-1302.. On page 1299, in Table 6, the values in the BARI Study for coronary-artery bypass grafting and percutaneous transluminal coronary angioplasty for the end point of death or ...

The Clinton administration and Congress, divided by political party and ideology, have nevertheless both claimed that balancing the federal budget by 2002 is their top priority. However, this seeming harmony is unlikely to prevent a prolonged struggle ...