Hematologic remission in acute lymphoblastic leukemia (ALL) is defined as fewer than 5 percent lymphoblasts in a light-microscopical examination of the bone marrow. However, in patients cured of childhood ALL, leukemia cells could persist even when no ...

Injections of aeroallergen extracts were first evaluated for the treatment of seasonal pollinosis in 1911 and have been widely used ever since as a treatment for respiratory allergy.¹,² Controlled trials have shown that immunotherapy relieves the symptoms ...

Serum cholesterol is one of the main risk factors for coronary heart disease, and in Western countries the prevalence of elevated cholesterol levels is high.¹ Recently, drugs have been developed that lower these levels effectively.

In the Scandinavian ...

In chronic myelogenous leukemia (CML) the Philadelphia (Ph) chromosome originates from a reciprocal translocation, t(9;22)(q34;q11),¹ that generates a chimeric BCR-ABL gene.² The disease is incurable without bone marrow transplantation. In some cases, ...

Figure 1. A 45-year-old man was found by police aimlessly wandering busy streets in a city 150 miles (240 km) from his home. He was confused and disoriented, but there was no evidence of substance abuse. His family was contacted and reported that he had ...

Insomnia is a common symptom, and clinicians need a diagnostic approach that allows them to choose from among many different types of therapy. This review focuses on the practical management of insomnia in adults¹ and on the scientific basis of current ...

Chronic viral hepatitis is the principal cause of chronic liver disease, cirrhosis, and hepatocellular carcinoma in the world and now ranks as the chief reason for liver transplantation in adults.¹–³ Of the five known hepatitis viruses, three can cause ...

Presentation of Case

A 37-year-old man with the acquired immunodeficiency syndrome (AIDS) was admitted to the hospital because of dyspnea and wheezing of three months' duration.

Nine years earlier, a test for antibodies against the human immunodeficiency ...

The advanced stages of many illnesses and their treatments are often accompanied by intractable nausea, vomiting, or pain. Thousands of patients with cancer, AIDS, and other diseases report they have obtained striking relief from these devastating ...

The success of treatment for childhood acute lymphoblastic leukemia (ALL) has been justifiably lauded. Some 70 percent of patients who receive optimal therapy and support can now expect to have a long-term remission and probable cure.¹ Most current ...

The Helsinki Declaration outlines clear ethical principles, including the basic concepts of informed consent, for physicians conducting biomedical research. There are guidelines for applying those principles specifically in research conducted in ...

To the Editor: Walsh et al. base a strong plea for the addition of combined chemotherapy and radiotherapy to the standard surgical treatment of adenocarcinoma of the esophagus (Aug. 15 issue)¹ on the results of a randomized trial of 113 patients. In ...

To the Editor: In his discussion of the differential diagnosis of Case 26-1996 (Aug. 22 issue),¹ Gorlin states that “neurocysticercosis (infection with tapeworm after the ingestion of raw pork) should be considered, despite the parents' statement that ...

To the Editor: We were surprised to find that the review of liver disease in pregnancy (Aug. 22 issue)¹ did not mention the recognized association between acute fatty liver of pregnancy and long-chain-3-hydroxyacyl-CoA dehydrogenase (LCHAD) deficiency,²–^...

To the Editor: Javaheri et al. (Aug. 22 issue)¹ report that short-term treatment with theophylline for periodic breathing in patients with cardiac failure reduces the number of episodes of apnea and the duration of arterial hypoxemia during sleep. ...

To the Editor: Although pulmonary involvement in adult-type Gaucher's disease (type 1) is unusual, as compared with the infantile type (type 2), previous reports have described aggregations of Gaucher cells within the alveolar spaces and interstitium in ...

To the Editor: The study by Hooton et al. (Aug. 15 issue)¹ of risk factors for urinary tract infections in young women was very interesting and informative, but what about the contraceptive methods they used? I was surprised not to see any mention of ...

This comprehensive book covers a wide range of topics relevant to the prevention of myocardial infarction: epidemiology, the pathogenesis of atherosclerosis and thrombosis, genetic determinants of atherosclerosis, smoking cessation, cholesterol reduction, ...

The aims of Cardiac Arrest: The Science and Practice of Resuscitation Medicine are to delineate the state of the art in the treatment of cardiopulmonary arrest, to complement the basic and advanced cardiac life-support guidelines of the American Heart ...

Ischemic Heart Disease is a major achievement for its sole author, Professor Attilio Maseri. It is the most comprehensive book published on this subject, with chapters on topics ranging from the biology of the myocyte to the management of acute myocardial ...

The care of patients with cardiovascular diseases has changed dramatically as new therapeutic options and improved classifications have evolved from clinical, epidemiologic, and experimental investigations. Numerous outstanding textbooks on cardiovascular ...

Last August, the Federal Trade Commission (FTC) and the Department of Justice liberalized their joint antitrust guidelines on health care.¹ The agencies agreed to review proposals for physician-operated networks case by case on the basis of their actual ...