Primary pulmonary hypertension is a rare, often fatal disease that tends to occur with particular frequency in women during their third or fourth decade.¹,² The factors leading to its development remain enigmatic. The occurrence of familial primary ...

The polycystic ovary syndrome is characterized by anovulation and hyperandrogenism. It affects approximately 6 percent of women of reproductive age.¹ Insulin resistance accompanied by compensatory hyperinsulinemia is a common feature of the syndrome, and ...

Neointimal hyperplasia and arterial remodeling cause restenosis in 20 to 50 percent of patients who have undergone coronary angioplasty.¹,² Although the mechanisms are unknown, previous findings have raised the possibility that cytomegalovirus (CMV) ...

Fulminant hepatic failure is a dramatic clinical syndrome characterized by massive necrosis of liver cells.¹ It is most often caused by hepatitis A virus and hepatitis B virus (HBV)²; whether hepatitis C virus (HCV) can cause it is still controversial.³,⁴ ...

In the United States, the hemolytic–uremic syndrome of childhood typically follows gastrointestinal infection with Escherichia coli O157:H7.¹–³ It is presumed that the absorption from the gastrointestinal tract of Shiga toxins 1, 2, or both (formerly ...

Figure 1. Cerebral imaging studies were performed in a 53-year-old man with a one-week history of headache, ataxia, and disorientation that culminated in right hemiparesis and coma. He had a remote history of dental abscesses. Magnetic resonance imaging ...

Uterine cancer is the fourth most frequent cancer in women, with an estimated 34,000 cases and 6000 deaths in the United States in 1996.¹ It is the most curable of the 10 most common cancers in women and the most frequent and curable of the gynecologic ...

Presentation of Case

A 31-year-old woman was admitted to the hospital because of pain in the left lumbar region and the left lower quadrant of the abdomen.

The patient had been well until 19 months before admission, when increasing pain developed in the ...

The cardinal clinical manifestations of the polycystic ovary syndrome are hirsutism and anovulation, oligomenorrhea, or amenorrhea. About half the women with this syndrome are obese, and some have diabetes mellitus. Underlying these clinical abnormalities ...

An association between appetite-suppressant drugs and primary pulmonary hypertension is reported by Abenhaim et al. in this issue of the Journal.¹ This important finding requires careful assessment, because the prevalence of obesity is increasing and ...

The hemolytic–uremic syndrome is characterized by nonimmune hemolytic anemia, thrombocytopenia, and acute renal failure.¹ Extrarenal manifestations, particularly neurologic signs, may be present, indicating that the disease process is not limited to the ...

With the enactment of an Oregon statute permitting physician-assisted suicide,¹,² the recognition of a constitutional right to assisted suicide by two U.S. courts of appeals,³,⁴ discussed elsewhere in this issue of the Journal, ⁵ and the acquittals of Dr. ...

To the Editor: As participants in the Food Advisory Committee assembled by the Food and Drug Administration (FDA) to consider the petition for approval of Olestra submitted by Procter & Gamble, we have a view of the approval process and recommendation of ...

To the Editor: The studies on low-molecular-weight heparin by Levine et al. and by Koopman et al. (March 14 issue)¹,² addressed the safety and efficacy of low-molecular-weight heparin given at home, as compared with standard heparin given in the hospital,...

To the Editor: In their study of the use of growth hormone to treat dilated cardiomyopathy (March 28 issue),¹ Fazio et al. describe the beneficial effects of administering recombinant human growth hormone for three months and urge the planning of longer ...

To the Editor: Cardiac arrest associated with pulseless electrical activity or electromechanical dissociation carries a poor prognosis unless a reversible cause is recognized and treated promptly. Reversible causes that are traditionally considered ...

To the Editor: The Image in Clinical Medicine of Drs. Kwan and Marsh (April 25 issue)¹ shows an excellent radiographic example of type 1 (distal) renal tubular acidosis with nephrocalcinosis, but there are some irregularities in the accompanying clinical ...

To the Editor: The article by Kenyon et al. (April 11 issue)¹ is reassuring to the air traveler, but I question two classification decisions made by the authors that may have affected their results and conclusions.

According to the Centers for Disease ...

This book is a delectation to be savored by anyone with an interest in infectious disease, cardiology, or the history of medicine. With a half century of passionate involvement in the study and treatment of infective endocarditis, Louis Weinstein's ...

Between about 1850 and 1950, the Festschrift (a collection of papers by the pupils or colleagues of an esteemed teacher or researcher) was a popular means of celebrating the career and contributions of a mentor. This two-volume work is of that genre. It ...

The term “cardiogenic embolism” refers to embolization from a cardiac source to a target organ. Cardiogenic Embolism is an excellent compendium of all proven, probable, or possible cardiac conditions that predispose patients to systemic emboli, but it ...

Memories of my renal training returned as I read the fifth edition of Brenner & Rector's The Kidney. It was nearly a decade ago that I read the entire third edition of this book during the first year of my nephrology fellowship. Nightly, even when ...

On an international scale, the number of scientists interested in research on kidney stones seems to have decreased in recent years. However, those who think that a few minimally invasive methods, such as shock-wave lithotripsy, meant victory over kidney-...

The debate over physician-assisted suicide has dramatically shifted to a discussion of constitutional issues. This spring, within a month of each other, U.S. Circuit Courts of Appeals on both coasts ruled that state prohibitions of assisted suicide are ...