Benign prostatic hyperplasia is a proliferative process that involves both the stromal and epithelial elements of the prostate.¹,² Its clinical manifestations include obstructive and irritative urinary tract symptoms, urinary retention, urinary tract ...

Atrial fibrillation is a common risk factor for ischemic stroke, particularly among the elderly.¹ Randomized trials have demonstrated that a relatively low intensity of anticoagulant therapy can largely eliminate the risk of stroke attributable to atrial ...

After several decades of steadily declining morbidity and mortality from group A streptococcal infections, the past 10 years have witnessed a striking resurgence in reports of severe disease, including the streptococcal toxic shock syndrome and ...

The human skeleton is a complex organ system consisting of more than 200 articulated bones of various shapes and sizes. During embryogenesis, the skeleton develops from undifferentiated mesenchyme according to a genetic plan that controls its precise ...

In most patients with the sleep apnea syndrome, episodes of apnea are due to obstruction of the upper airways (obstructive apnea). Application of nasal continuous positive airway pressure eliminates the obstruction and thus prevents associated arterial ...

Figure 1. Three large Negri bodies, which are eosinophilic viral inclusion bodies, can be seen in the cytoplasm of a cerebellar Purkinje cell obtained at autopsy from an eight-year-old boy in Mexico City (hematoxylin and eosin, ×2300). These viral ...

Liver disease is a rare complication of pregnancy, but when it occurs it may do so in a dramatic and tragic fashion for both mother and infant. Diseases such as acute fatty liver of pregnancy (AFLP) may begin innocuously with mild symptoms and liver-...

Presentation of Case

A seven-year-old boy was admitted to the hospital because of fever, lymphadenopathy, hepatosplenomegaly, and eosinophilia.

The boy had been in good health until two months earlier, when fever and disorientation developed. He was taken ...

Medications to treat benign prostatic hyperplasia fall into two main categories: α₁-adrenergic–antagonist drugs, which relax smooth muscle in the prostate, and drugs that inhibit 5α-reductase, which shrink the prostate by blocking the formation of the ...

Treatment with oral anticoagulant drugs (i.e., coumarin derivatives such as warfarin) is effective in the prevention of venous and arterial thromboembolism. In patients with atrial fibrillation, anticoagulation reduces the risk of stroke by 70 percent.¹ ...

Several reports during the past decade have suggested that there has been an increase in the number of serious invasive streptococcal infections, with or without shock. The common routes of entry for beta-hemolytic streptococci (mainly group A) are the ...

Just as the study of rare inborn errors of metabolism has yielded important insights into normal metabolic pathways, the study of rare genetic defects can help define the roles of cellular morphogens and their receptors. The recent demonstration of ...

To the Editor: The Clinical Problem-Solving article entitled “The Invisible Patient” (April 4 issue)¹ describes a patient who died of bowel ischemia that manifested clinically several hours after coronary angiography. The discussant attributed the ...

To the Editor: Maschio et al. (April 11 issue)¹ focus their conclusions on a specific renoprotective effect of benazepril in patients with chronic renal insufficiency. However, we question whether the drug has a specific renoprotective effect, because ...

To the Editor: Rivo and Kindig (April 4 issue)¹ provide a report card on the physician work force in the United States. Evidently, the residency programs in certain urban areas do not have the educational quality to attract the best residents, perhaps ...

To the Editor: I agree with the conclusions of Wechsler et al. (April 11 issue)¹ but was dismayed to see that adult immunization was not on the list of health-promoting activities that physicians were queried about. As the authors point out, some of the ...

To the Editor: Six years ago, Fine et al. reported two instances in which Lasix (furosemide) was confused with Losec, the trade name for omeprazole at that time.¹ Later that year, Merck Sharp & Dohme announced that to prevent further confusion, the name ...

Bill Clinton was elected President on November 3, 1992, after promising to introduce a legislative proposal for comprehensive health care reform within 100 days after his inauguration. It was a popular message, and many observers believed that George Bush'...

A quarter of a century ago, a recent Rhodes scholar on his way to law school wrote a book described as an “exuberant account of the workings of the United States Senate.” The book recounted how, while working as an aide to Senator Warren Magnuson in 1970, ...

Effect of Immunization with a Common Recall Antigen on Viral Expression in Patients Infected with Human Immunodeficiency Virus Type 1 Original Article, N Engl J Med 1996:334;1222-1229.. On page 1227, in Figure 3, panel C, the y-axis should have been ...

Survival of Medicare Patients after Enrollment in Hospice Programs Special Article, N Engl J Med 1996:335;172-178.. On page 174, in Table 1, several of the median survival values were incorrect. The correct values are as follows: urinary tract, 34 days; ...