Although stroke is a leading cause of death and disability in developed countries, there is no established treatment for acute ischemic stroke. Reperfusion is one possible approach. Interest in reperfusion with thrombolytic agents has been renewed ...

Hysteroscopic ablation of the endometrium has become an accepted alternative to hysterectomy in the treatment of menorrhagia.¹ More than 10,200 of these procedures were performed in England and Wales from April 1993 through October 1994,² for instance, ...

Allogeneic bone marrow transplantation can cure some hematologic cancers, bone marrow failure syndromes, immunodeficiency disorders, and inborn errors of metabolism,¹–⁵ but its success depends on the prompt identification of a suitable donor and the ...

To circumvent the problems inherent in allogeneic bone marrow transplantation, allogeneic cord blood has been studied as an alternative source of hematopoietic stem cells. Preliminary results with cord blood from an HLA-matched sibling are encouraging, ...

Figure 1. Computed tomography in a 52-year-old woman with mild episodic gross hematuria revealed compression of the left renal vein between the superior mesenteric artery (SMA) and the aorta (Ao) before the vein merges into the inferior vena cava (IVC). ...

The primary goal of hospice care is the palliation of patients' physical and mental suffering. Hospice care may offer several advantages over traditional, hospital-based care for people with terminal illnesses. It can be delivered in a patient's home, ...

Cystic fibrosis is the most common life-shortening autosomal recessive disorder in the white population, affecting approximately 30,000 persons in the United States.¹ It is caused by mutations in a single gene on the long arm of chromosome 7 that encodes ...

Presentation of Case

A 69-year-old, right-handed woman was admitted to the hospital because of a left parieto-occipital hemorrhage during treatment with warfarin for transient cerebral ischemic attacks.

The patient had been well until 30 months earlier, ...

Menorrhagia (also termed hypermenorrhea) is a common problem among women of reproductive age. One quarter of middle-aged British women studied in household surveys reported heavy menstrual bleeding that has interfered with their lives.¹ Menorrhagia is the ...

Bone marrow has for years been the principal source of transplantable hematopoietic stem cells and progenitor cells. For bone marrow transplantation to succeed, it is crucial to find a donor whose HLA types match those of the recipient. If there is no ...

Growing up in West Virginia, I would hear older folks say, “Mr. Jones is failing now.” They meant that he had entered the final phase of disease and was now too tired to fulfill his usual obligations or even to care for himself and that he would soon take ...

To the Editor: Creticos et al. (Feb. 22 issue)¹ found that in adults with asthma exacerbated by seasonal exposure to ragweed, immunotherapy improved objective measures of asthma and allergy, but the clinical effects were limited, and many were not ...

To the Editor: We wish to highlight morphologic and hemodynamic characteristics of the pulmonary microcirculation that strongly support the concept of stress-induced failure of pulmonary capillaries in high-altitude pulmonary edema rather than pulmonary ...

To the Editor: Reiman et al. (March 21 issue)¹ conclude that abnormalities in glucose metabolism, evaluated by positron-emission tomography (PET) in asymptomatic subjects homozygous for the ε4 allele for apolipoprotein E, provide preclinical evidence of ...

To the Editor: Rees et al. (Nov. 23 issue)¹ reported that patients with the Guillain–Barré syndrome and recent infection with Campylobacter jejuni have a more severe residual disability after one year than patients without C. jejuni infection. In later ...

To the Editor: Drs. Watemberg and Morton (March 7 issue) describe a case of herpes simplex encephalitis in a 13-year-old boy and present the classic electroencephalographic finding of periodic lateralized epileptiform discharges.¹ Whereas it is ...

To the Editor: Although Williams's study of the costs of visits to emergency departments (March 7 issue)¹ appears to be generally well designed, I believe its whole premise is penny-wise and pound-foolish. When performed in many millions of patients, ...

To the Editor: We surveyed the frequency of condom use in 1995 by 147 women at a private university in New England and compared it with that reported previously in the Journal for 486 women surveyed in 1975, 161 women surveyed in 1986, and 132 women ...

This new textbook of pediatric oncology reflects and memorializes the career of its editor, Carl Pochedly, who died last year. Pochedly was a founder of the American Society of Pediatric Hematology/Oncology and the founding editor of its journal, and his ...

Aberrations of the immune system are of great importance in clinical medicine. Our knowledge of basic immunology and its clinical application is expanding rapidly. Immunologic Disorders in Infants and Children was first published in 1973. Publication of ...

A number of excellent textbooks are available for perinatologists who care for high-risk obstetrical patients or neonatologists who care for newborns. In practice, perinatologists and neonatologists collaborate closely to optimize the outcome for mother ...

The editors of Pediatric and Neonatal Tests and Procedures sought to fill a void with this textbook. Their goal was to present the type of book most requested by pediatricians, pediatric subspecialists, and those in training: an easy-to-read, concise, up-...

The Enteric Nervous System Review Article, N Engl J Med 1996:334;1106-1115.. On page 1111, halfway down the leftmost column of Table 3, Sipple's syndrome should have been listed as an alternative name for multiple endrocrine neoplasia type 2A (MEN-2A), ...