Two years ago, the Pediatric AIDS Clinical Trials Group (ACTG) Protocol 076 study demonstrated that zidovudine dramatically reduced the risk of maternal–infant transmission of human immunodeficiency virus type 1 (HIV-1).¹ The availability of a treatment ...

In-line skating is a fast-growing recreational sport in the United States. In-line skates, with three, four, or five low-friction wheels set in a single row, afford greater maneuverability and speed than traditional quad skates, which have four wheels ...

In the United States, one third of patients with end-stage renal disease who receive renal dialysis or transplantation have diabetes mellitus, and most of these have non-insulin-dependent diabetes mellitus (NIDDM).¹ The pathogenesis and progression of ...

The Canale–Smith syndrome, first described in 1967,¹ is an uncommon cause of lymphadenopathy in children.²–⁴ Patients with the syndrome present within the first two years of life with lymphadenopathy, hepatosplenomegaly, hemolytic anemia, and ...

Figure 1. A 76-year-old woman with breast cancer who had been receiving adjuvant therapy with tamoxifen (20 mg per day) for 30 months presented with minimal vaginal bleeding. Color Doppler imaging revealed multiple arterial vessels with a very low ...

Lymphocytes are equipped to eradicate noxious agents (microbes, cancer cells, and grafts) that disturb the body's equilibrium, but when their cellular activity is excessive, the results are harmful. The list of abnormalities known to be caused by ...

Despite improvement in primary prevention¹ and treatment,² acute myocardial infarction remains the chief cause of death in the United States and most developed countries. Almost half of all victims of myocardial infarction die before they reach the ...

Presentation of Case

A 51-year-old man was admitted to the hospital because of visual “instability” and an intracranial mass.

The patient was an accountant. He had been well until six years earlier, when he began to have difficulty fixating on the proper ...

Euthanasia (the deliberate administration of a lethal drug to hasten death in a suffering patient) is officially a crime in the Netherlands, punishable by up to 12 years in prison, but its practice has been accepted there for over 20 years, protected by a ...

For nearly three years we have known that zidovudine is efficacious in preventing transmission of the human immunodeficiency virus (HIV) from mother to infant.¹ A randomized, placebo-controlled trial, AIDS Clinical Trials Group Protocol 076, established a ...

In-line skating has burgeoned in popularity in the United States, with participation increasing from 6.2 million in 1991 to 22.5 million by 1995.¹,² For the uninitiated, in-line skates differ from roller skates in that the wheels — four or five of them — ...

A clinical diagnosis of diabetic nephropathy can be made in a patient with diabetes on the basis of persistent albuminuria (>300 mg per 24 hours), the presence of diabetic retinopathy, and the absence of any clinical or laboratory evidence of other kidney ...

To the Editor: Tibbles and Edelsberg (June 20 issue)¹ present a complete and cogent summary of the therapeutic usefulness of hyperbaric-oxygen therapy. However, their review contains a recommendation that is not supported by evidence. In the section on ...

To the Editor: In the Clinical Problem-Solving article entitled “The Illusion of Certainty” (July 4 issue),¹ Dr. Wolinsky provides an informative and constructive critique of the case presentation and the discussant's thoughts. I was disappointed, ...

To the Editor: The words of warning against overreliance on angiographic findings in the coronary arteries in the editorial comments by Wilson (June 27 issue)¹ were appropriate but not new.² It is difficult to calculate the precise degree of flow ...

To the Editor: Chen et al. (July 4 issue)¹ report excellent results with the use of the Inoue balloon catheter in treating congenital pulmonic stenosis in adolescents and adults. Missing from the article, however, is any mention that the authors obtained ...

To the Editor: In discussing Case 20-1996, which involved a congenital cystic adenomatoid malformation of the lung (June 27 issue),¹ Dr. Kinane states that the diagnostic and therapeutic procedure is a resection of the abnormal tissue. This may not ...

To the Editor: Last year we reported finding Epstein–Barr virus (EBV) in smooth-muscle–tumor cells in leiomyosarcoma tissues from patients with the acquired immunodeficiency syndrome (AIDS).¹ This was the first evidence of EBV infection of nonlymphoid ...

To the Editor: Péoc'h and colleagues (July 11 issue)¹ reported a systemic granulomatous reaction to a foreign body after a hip replacement. We recently reported a case of a sarcoid-like reaction to particulate debris from a failed total knee replacement ...

To the Editor: I recently saw two lawyers. The first was my own attorney, who did some work for which he charged me $185 per hour. I did not consider this unreasonable. The second was a patient in my internal-medicine practice. His law firm belongs to a ...

This book on people and ideas contains interesting and often amusing information about the founders of respiratory physiology, with a minimum of complicated diagrams and jargon. Its five parts cover morphology, gas exchange and blood flow, mechanics, ...

Recently, there have been astounding advances in immunology with the introduction of molecular biology into this discipline. The application of this new knowledge to specific organs, such as the lung, has necessarily lagged behind, but this book attempts ...

The title of this book is slightly misleading. The book does not present clinical problems, each followed by a discussion and solutions. It is instead a concise textbook of clinical nephrology, and as Black states, it provides “quick access to the ...

Gastroenterologists who believe that “to know Crohn's disease is to know medicine” may overstate the case. Yet physicians familiar with this singular chronic illness cannot help but be struck by its variable clinical course and the diversity of its ...

It comes as no surprise that this third edition of Disorders of Hemostasis differs considerably from the second one (1991), because of the rapid progress in the field. O.D. Ratnoff, one of the nestors of hemostasis, sets the stage with a historical ...

It would take a mixture of hubris and chutzpah for one person to attempt to master enough of the vast literature of hematology to write a comprehensive textbook on the topic. Not only has one person, James Jandl, done so in his Blood, but he has also ...

In the Netherlands, euthanasia and physician-assisted suicide have been practiced with increasing openness, although technically they remain illegal. In 1990–1991 a nationwide study of euthanasia and other medical practices related to the ending of life ...

Medical decisions are normally made in the privacy of the doctor–patient relationship.¹ Decisions that involve physician-assisted death, however, require at least regulatory oversight because of the risk of abusing vulnerable patients.² A primary concern ...