Adenocarcinoma of the ovary causes the death of more American women each year than all other gynecologic cancers combined. About 5 to 10 percent of ovarian cancers are familial, and several familial-cancer syndromes that include ovarian cancer have been ...

Mitral regurgitation is a common heart-valve disorder that is often difficult to manage. Symptoms may be absent for years,¹ despite severe regurgitation. Surgical correction of mitral regurgitation can relieve symptoms,² but when it is performed in ...

Valvular disease is the most prevalent and clinically important form of cardiac involvement in patients with systemic lupus erythematosus,¹–⁴ but little is known about its relation to the clinical features of the disorder. In addition, changes over time ...

Perinatal human immunodeficiency virus (HIV) infection generally has a more rapid course than HIV infection in adults.¹,² The pattern of progression is bimodal, with the acquired immunodeficiency syndrome (AIDS) developing in a subgroup of infants very ...

Figure 1. One of the most frequently isolated pathogens in gram-negative pneumonia, klebsiella can also cause urinary tract infections, intraabdominal infections, and respiratory tract infections. The organism has gained some renown in recent years as the ...

Injuries due to firearms are a major health problem in the United States.¹–⁴ Although several studies have documented the impact of firearm-related deaths,⁵–¹⁵ little is known about the epidemiologic characteristics of nonfatal gunshot wounds.¹⁶–¹⁸ ...

Since their discovery, antimicrobial drugs have proved remarkably effective for the control of bacterial infections. However, it was soon evident that bacterial pathogens were unlikely to surrender unconditionally, because some pathogens rapidly became ...

The identification of BRCA1 as the first gene for susceptibility to breast and ovarian cancer was an important step toward a better understanding of the biology of these cancers.¹ This advance should lead to new therapies, but for now it provides a unique ...

In this issue of the Journal, Ling et al.¹ present a retrospective study of long-term clinical outcomes in a large group of patients with mitral regurgitation diagnosed at the Mayo Clinic. Because the study included only patients with a diagnosis of ...

To the Editor: Your editorial (Aug. 15 issue)¹ addresses critical issues in outpatient training. Having recently finished a training program in neurology, I would emphasize the lack of adequate exposure in such programs to diseases that are now treated ...

To the Editor: We believe that more data are needed before polyprenoic acid can be accepted as an effective drug for the adjuvant treatment of hepatocellular carcinoma, as reported by Muto et al. (June 13 issue).¹ We are concerned about several issues ...

To the Editor: The correspondence regarding benign cardiac myxoma, malignant myxoma, and cardiac sarcoma (May 23 issue)¹–³ clouds, rather than clarifies, a subject that is generally misunderstood by clinicians and pathologists. Figure 1 of the case ...

To the Editor: The excellent article by the French Study of Aortic Plaques in Stroke Group (May 9 issue)¹ shows that the presence of large atheromas in the proximal aorta, already known to be an independent risk factor for first ischemic stroke in the ...

To the Editor: Ubel et al. (May 2 issue)¹ hypothesize that a budget is to be used in screening for colon cancer. The overriding question is “Who established the budget for medical services?” Before we can begin choosing among effective medical actions, a ...

To the Editor: In 1989, the National Research Council¹ published a comprehensive and authoritative examination of the role of diet in disease, which on the basis of the evidence, proposed dietary guidelines for promoting health and reducing the risk of ...

The photograph of Bruno Bettelheim on the cover of this new and masterly biography encapsulates many of the powerful and conflicting images that have come to define this complex man. He is seated, reading, in front of an elaborate candelabrum, an elderly ...

Child and Adolescent Psychiatry is intended for the general pediatrician and the family practitioner, but it is so succinct and well written that any professional in a health-related field who works with children and adolescents could use it. It would be ...

This is the most important book on psychoanalysis since those of Freud. First published in 1945, six years after Freud's death and just months before the premature death of its brilliant young author, it was greeted with uniform acclaim. In his epilogue ...

The theme of this year's 11th International AIDS Conference, “One World, One Hope,” was amply borne out, for better and for worse, by the presentations. For the first time in years, there was a real feeling of optimism about the potential for treatment, ...

Case Records of the Massachusetts General Hospital (Case 21-1996) Case Records of the Massachusetts General Hospital, N Engl J Med 1996:335;115-122.. The sentence that begins in the last line of page 121 and continues on page 122 should have read, “The ...