Zidovudine improves survival and decreases the incidence of opportunistic infections among patients with advanced infections with human immunodeficiency virus type 1 (HIV-1) and slows the progression of disease in patients with no or mild symptoms.¹–⁵ Its ...

The AIDS Clinical Trials Group Study 175 (ACTG 175) provides direct evidence, in the clinical report elsewhere in this issue of the Journal, ¹ of the clinical and immunologic benefits (e.g., increased CD4 cell counts) of the treatment of human ...

Better treatments are needed for patients with human immunodeficiency virus (HIV) infection and a condition characteristic of the acquired immunodeficiency syndrome (AIDS) or severe immune suppression. Prior investigations have found that didanosine or ...

Short-term or long-term treatment with calcium-channel blockers may worsen heart failure and increase the risk of death in patients with advanced left ventricular dysfunction.¹–⁴ The possibility of such effects has been noted with most drugs in this class,...

Hypocalcemia is the hallmark of hypoparathyroidism, which may be inherited either as an isolated endocrinopathy or as part of an autoimmune polyendocrinopathy–candidiasis–ectodermal dystrophy or the DiGeorge syndrome, in which developmental defects of the ...

Figure 1. A 26-year-old woman who was positive for the human immunodeficiency virus presented with focal motor seizures, a CD4 cell count of 238 per cubic millimeter, a rapid plasma reagin titer of 1:32, and a positive test for serum treponemal IgG ...

Pain from cancer is a major health care problem.¹–³ Thirty percent of patients with cancer have pain at the time of diagnosis, and 65 to 85 percent have pain when their disease is advanced.²,⁴–⁶ The impact of cancer pain is magnified by the interaction of ...

Presentation of Case

An 18-month-old boy was admitted to the hospital because of a persistent cough and increasing tachypnea.

The infant had been born at 31 weeks' gestation. A grade 1 intraventricular hemorrhage, detected by cranial ultrasonographic ...

In this issue of the Journal three important articles appear, with major implications for the clinical management of infection with the human immunodeficiency virus (HIV).¹–³ Hammer et al.¹ and Katzenstein et al.² describe the clinical and virologic ...

Familial benign hypercalcemia, also known as familial hypocalciuric hypercalcemia, was first identified clinically when patients thought to have primary hyperparathyroidism whose condition did not improve after neck surgery were found to have relatives ...

The current concern about quality of care in the United States is deeply paradoxical in many ways. From a technical and scientific standpoint, the capabilities of the nation's health care system are extraordinary. Decades of biomedical research have ...

One of the most serious threats medical students face during their clinical training is the possibility of exposure to blood-borne pathogens, with the attendant risk of infection with the human immunodeficiency virus (HIV), hepatitis B virus (HBV), or ...

To the Editor: As an educator and academic biomedical scientist, I found the lengthy Special Article by Dr. Angell on silicone-gel–filled breast implants (June 6 issue)¹ inconsistent with the scientific standards we have come to expect from the Journal. ...

To the Editor: The study by Hannah et al. (April 18 issue)¹ exemplifies the best of evidence-based medicine: it is a multicenter, randomized, prospective trial with a large patient population and blinded outcome assessment. Despite the trial's ...

To the Editor: The incidence of seizures in neurosyphilis ranges from 14 to 60 percent,¹ with no reports of focal status epilepticus as a presenting complaint. We describe a patient in whom cerebral syphilitic gumma was the underlying cause of focal ...

To the Editor: Schömig et al. (April 25 issue)¹ report that they did not observe neutropenia in any of the 257 patients receiving short-term ticlopidine therapy after coronary stenting. The authors note that in the literature, all reported cases of ...

To the Editor: In his editorial on platelets and coronary artery disease (April 25 issue),¹ Handin states, “Aspirin has now become an essential cardiovascular drug, and it is unusual to find patients with established coronary artery disease who do not ...

It was a rainy Good Friday in 1954. A fellow intern at the Brooklyn Jewish Hospital agreed to cover for me. I took the subway to the Metropolitan Opera House to see Parsifal, an opera I have seen every year since. One of Parsifal's overwhelming moments ...

In these times of overflowing information, when the medical books and articles published every year number in the thousands, it is difficult to recommend a new book to readers of the Journal. This is even harder in the case of a book such as Winokur and ...

The complex relations among disease, science, attitudes, beliefs, and society are richly documented in Frank Snowden's fascinating book Naples in the Time of Cholera, 1884–1911. In 1884, science was just beginning to have an impact on the understanding of ...

Participation in a recent ethics symposium at our hospital required one to read The House of God. For most of us, it was not the first time we had read the novel, but rather a return to it after 15 years. It is worth revisiting The House of God because of ...

Management of Pulmonary Disease in Patients with Cystic Fibrosis Review Article, N Engl J Med 1996:335;179-188.. On page 182, in Table 2, under the heading “First Choice,” the dosage of gentamicin used to treat H. influenzae and S. aureus should have read,...

Case Records of the Massachusetts General Hospital (Case 22-1996) Case Records of the Massachusetts General Hospital, N Engl J Med 1996:335;189-196.. On page 192, the sentence that begins in line 31 of the left-hand column should have read, “When the ...