Anabolic–androgenic steroids are widely abused by athletes and recreational bodybuilders because of the perception that these substances increase muscle mass and strength,^1-9 but this premise is unsubstantiated. Testosterone replacement increases nitrogen ...

Soon after oral contraceptives were first marketed, case reports appeared of pulmonary embolism¹ and ischemic stroke² in women using these drugs. By the early 1970s, epidemiologic studies had confirmed a link between the current use of oral contraceptive ...

Wegener's granulomatosis is a disease of presumed autoimmune origin characterized by necrotizing granulomatous inflammation of the upper and lower airways and necrotizing vasculitis that is especially likely to involve the kidneys.¹ In untreated patients, ...

Since 1982,¹ percutaneous balloon valvuloplasty has become established as a preferred method of therapy for congenital pulmonic stenosis in children. However, the usefulness of this technique for treating adolescents and adults with pulmonic stenosis is ...

Figure 1. A 46-year-old man presented with a 50-lb (23-kg) weight loss and diarrhea. An electron micrograph (Panel A, ×6913) of tissue from the small bowel showed numerous extracellular bacilli (Tropheryma whippelii; A), a phagosome containing bacilli (B) ...

Burns are the fourth leading cause of death from unintentional injury in the United States and result in 1.4 million injuries each year.^1,2 Residential fires cause over 75 percent of all deaths from fires and burns.^3-6 The southern part of the United ...

Spontaneous pain, pain provoked by trivial stimuli, and altered sensation accompany herpes zoster and may continue long after its characteristic rash has healed — a condition known as postherpetic neuralgia. Many approaches have been proposed to treat the ...

Maintaining vascular integrity and defending against invasive pathogens require the rapid regulation of adhesive interactions among blood cells and between blood cells and the vessel wall. Control of these mechanisms depends on the activation of adhesion ...

Stage

A 42-year-old man saw a physician because he had had pain in both hips for several months. The pain was made worse by climbing stairs and ladders and was more severe on the left side. Ibuprofen provided no relief. He thought the problem might be ...

Competing philosophies about the desirability of change confront managers, business leaders, politicians, and even medical editors. The common-sense advice of Bert Lance, President Carter's director of the Office of Management and Budget — “If it ain't ...

The paper by Bhasin et al.¹ in this issue of the Journal shows that a dose of testosterone enanthate (600 mg weekly for 10 weeks) that produces supraphysiologic serum concentrations of testosterone in men increases muscle size and strength and that the ...

For decades it has been known that oral contraceptive drugs are one of the most effective forms of birth control. Despite their clear and substantial benefits, concern has remained about the short-term and long-term risks associated with these agents. The ...

Many medical treatments are based on sheer empiricism. In 1975 I noted that trimethoprim–sulfamethoxazole had a salutary effect in a woman with Wegener's granulomatosis involving all major sites, including the upper respiratory tract, lungs, and kidneys. ...

To the Editor: In his Health Policy Report on managed care and mental health (Jan. 11 issue),¹ Iglehart inaccurately characterized my campaign for the presidency of the American Psychiatric Association. It was based on timehonored clinical and scientific ...

To the Editor: In their article “Compensation to a Department of Medicine and Its Faculty Members for the Teaching of Medical Students and House Staff,” Shea et al. (Jan. 18 issue)¹ attribute all the hours spent by attending physicians on wards to ...

To the Editor: Before medical professionals consider changing their practice of administering thrombolytic agents on the basis of the presence or absence of preinfarction angina, as is suggested by Andreotti et al. (Jan. 4 issue),¹ we feel obligated to ...

To the Editor: Kimura et al. reported (Feb. 29 issue)¹ that in patients treated with Palmaz–Schatz coronary-artery stents the rate of survival free of myocardial infarction, bypass surgery, and revascularization of the target lesion was 80.4 percent at ...

To the Editor: A 32-year-old man infected with the human immunodeficiency virus (HIV) since 1987 presented in May 1993 with scaly, erythematous skin plaques. His CD4 count was 403 per cubic millimeter. In June 1994, he was admitted because of a ...

To the Editor: In his letter to the Editor (Jan. 18 issue),¹ Dr. Waters accuses the University of Iowa Injury Prevention Research Center of using funds from the Centers for Disease Control and Prevention (CDC) intended for the study of farm injuries to ...

This book, dedicated to the biology and treatment of epithelial ovarian cancer, is the third or fourth such publication within the past four years, a reflection of the intense interest in this tumor, which is moderately sensitive to therapy and ...

This book is a concise, up-to-date review of the number-one cancer in men: prostate cancer. The 14 chapters address topics ranging from epidemiology and molecular biology to the management of localized and advanced cancer. The chapters are well organized ...

In the preface to this book, Dr. Weidner states that 5 to 10 percent of specimens routinely submitted to surgical pathology laboratories pose difficult diagnostic problems for the pathologist. He notes that a number of excellent textbooks on surgical ...

The superior searching capabilities and fast retrieval of computerized drug data bases are important for routine clinical work. Their incorporation into the hectic environment of the medical office and hospital unit can make the difference between ...

I was sitting around minding my own business when Death — in the form of Allan Kellehear's new book — tapped me on the shoulder. Thinking of my own near miss (1991, back seat of a runaway Checker taxi), I picked up Experiences near Death for more clues to ...