On January 17, 1994, at 4:31 a.m., Los Angeles County was jolted by an earthquake centered near Northridge, California — one of the strongest earthquakes ever recorded in a major city in North America.^1,2 In this unusual situation, millions of people were ...

The main pathogenetic factor causing anemia in end-stage renal disease is the diminished synthesis of erythropoietin in diseased kidneys.¹ Before the availability of recombinant erythropoietin (epoetin),² the mainstays of anemia therapy in end-stage renal ...

Assessments of the efficacy of antiretroviral therapy based on clinical end points in patients with early or intermediate stages of human immunodeficiency virus (HIV) infection typically take many years.^1-5 As new antiretroviral agents become available, ...

The causes of growth hormone–dependent short stature are primary pituitary disease, pituitary deficiency due to hypothalamic dysfunction, and, less often, insensitivity to growth hormone. The prototypical syndrome of growth hormone insensitivity is Laron-...

Figure 1. A 61-year-old roads inspector from Illinois presented in 1992 with hemolytic anemia and acrocyanosis and was found to have cold-agglutinin syndrome. He was treated with plasmapheresis, prednisone, and chlorambucil and then followed without ...

During the past 20 years, natural disasters have claimed more than 3 million lives worldwide, affected at least 800 million people, and resulted in property damage exceeding $50 billion.¹ The recent earthquake of magnitude 7.2 in Kobe, Japan, left more ...

Gout is a clinical syndrome resulting from the deposition of urate (monosodium urate monohydrate) crystals. The crystals may be deposited in a joint, leading to an acute inflammatory response, or in soft tissues, such as cartilage, causing no ...

Presentation of Case

A 25-year-old man was admitted to the hospital because of persistent chest pain and dyspnea after an injury.

The patient had been well until one week earlier, when a bale of newspapers weighing an estimated 900 kg fell on his chest. ...

At 4:31 a.m. on January 17, 1994, a violent earthquake centered near Northridge, California, suddenly awakened millions of citizens of Los Angeles and subjected them to intense fright. The earthquake not only caused deaths from trauma, as would be ...

The association of anemia with renal failure was noted by Richard Bright 160 years ago.¹ Anemia develops early in the course of renal failure, becomes prominent as the disease progresses, and contributes substantially to disability. Patients with renal ...

Postnatal growth and, to a much lesser degree, intrauterine growth are critically dependent on the expression of the pituitary growth hormone GH-1 gene and the consequent generation of insulin-like growth factor I (IGF-I) in the liver and other tissues. ...

Each year thousands of reviewers contribute their expertise to peer review, a process that contributes critically to the quality of the Journal. The editors and the authors of the papers submitted to the Journal are grateful for the help of all our ...

To the Editor: Professor Annas's article “The Health of the President and Presidential Candidates — The Public's Right to Know” (Oct. 5 issue)¹ reaches back in time to the illnesses and disabilities of President Eisenhower. Unfortunately, references to ...

To the Editor: The studies by Goldstein and Whelan and their colleagues (Oct. 12 issue)^1,2 indicate that p16 mutations are required for the development of pancreatic cancer in 10 melanoma-prone kindreds in the United States, Australia, and the ...

To the Editor: As Rozman and Montserrat state in their fine overview of the treatment of chronic lymphocytic leukemia (Oct. 19 issue),¹ there are no curative options, so palliative treatment is a reasonable and important therapeutic goal. Unfortunately, ...

To the Editor: Patients with cancer may have a variety of metabolic and immunologic abnormalities that are thought to be caused by different humoral factors secreted by the tumors and are called paraneoplastic syndromes.¹ We have seen several patients ...

To the Editor: I applaud Drs. Walsh and Peterson (Oct. 12 issue)¹ for their review of treatment regimens for the eradication of Helicobacter pylori. In Table 1 of their article, several treatment regimens are presented with accompanying data on efficacy ...

To the Editor: Six young men presented with various degrees of keratoconjunctivitis due to alkaline chemical burns. They had received these injuries during an evening of dancing on a dance floor covered with several feet of foam, similar in appearance to ...

The publication of another major textbook on pediatric infectious diseases reflects the continuing growth of a subspecialty whose existence has recently been validated by the American Board of Pediatrics with the establishment of certification for its ...

As human immunodeficiency virus (HIV) infection in children becomes a more chronic disease, with an increased mean life expectancy, and as the total number of children with HIV infection and AIDS increases, a textbook such as this one makes a valuable ...

Austin, Texas, was recently in the spotlight because of the birth and subsequent separation of a set of conjoined twins. That such infants capture the public imagination was not lost on the administrators of our local hospital (or P.T. Barnum, for that ...

Readers seeking a book that provides guidance on the care of the pregnant patient acutely ill with a genetic illness need to look elsewhere. However, this book is required reading for those seeking to achieve the book's stated goal: “to sensitize the ...

Antiepileptic Drugs Review Article, N Engl J Med 1996:334;168-175.. On page 169, the second line from the bottom of the left-hand column should have read, “or the leukocyte count falls below 2000 per cubic [millimeter],” not “2,000,000,” as printed.