Ehrlichia are intracellular organisms that may infect a variety of mammalian hosts.¹ The rapid emergence of a new human ehrlichial infection, human granulocytic ehrlichiosis, was recently reported. This infection was first recognized in north central ...

The internal thoracic artery (ITA) graft, which is used in coronary-artery bypass surgery, has been found in many single-institution clinical studies to be a superior conduit.¹–³ The Coronary Artery Surgery Study (CASS), a multicenter study with ...

Antithyroid drugs are effective in controlling hyperthyroidism because they inhibit thyroid hormone production. In patients with hyperthyroidism caused by Graves' disease, these drugs may also have an immunosuppressive effect, causing a decrease in the ...

Neuroblastoma is a childhood cancer that originates in cells of the neural crest. The clinical course of the disease varies widely.¹ Patients with localized neuroblastoma (those in stages I and II) have a good prognosis after surgical resection, whereas ...

Neuroblastoma is the most common solid tumor of early childhood.¹ Patients with localized disease have a favorable prognosis, but the majority of children with neuroblastoma present with metastases and have poor prognoses despite intensive multimodal ...

Figure 1. A 32-year-old man who had attempted suicide with a nail gun directed at his heart just to the left of the sternum presented to the emergency room with cardiac tamponade. The chest x-ray film (Panel A) revealed a nail (arrow), apparently in the ...

Streptococcus pyogenes (group A in the Lancefield classification) is one of the most common human pathogens. Although this ubiquitous organism is responsible for a wide array of illnesses, most attention has focused on its relation to acute pharyngitis, ...

A peptide inhibiting the release of growth hormone was originally detected accidentally during studies of the distribution of growth hormone–releasing factor in the hypothalamus of rats.¹ This peptide, called somatostatin, proved to be a cyclic peptide ...

Presentation of Case

A 31-year-old woman with a documented first pregnancy of four weeks' duration was admitted to the hospital because of severe pain in the left lower quadrant of the abdomen, nausea, and vomiting.

The patient had been well until 9 p.m. ...

Ehrlichia are obligate intracellular coccobacilli resembling rickettsia that have historically been associated with diseases of animals. The etiologic agent of the hemorrhagic illness canine ehrlichiosis, Ehrlichia canis, was first recognized in 1935, and ...

The development of internal-thoracic-artery grafting is the most remarkable achievement in coronary-artery surgery. In the past two decades, numerous studies have confirmed that the patency rate of internal-thoracic-artery grafts is excellent and that ...

Fifty years have passed since radioactive iodine and antithyroid drugs became available for the treatment of hyperthyroidism caused by Graves' disease. Despite the efficacy of both treatments, opinions still diverge widely as to which is better. A course ...

To the Editor: Telzak et al. (Oct. 5 issue)¹ report on a series of persons in New York city who had multidrug-resistant tuberculosis but were not infected with the human immunodeficiency virus (HIV). The authors conclude that “contrary to previous ...

To the Editor: After the completion of the studies reported by DeFronzo et al. (Aug. 31 issue),¹ metformin was introduced into use in the United States. As of October 30, 1995, the Food and Drug Administration (FDA) Medwatch reporting program (1-800-FDA-...

To the Editor: We were quite surprised that the remarkable review of mitochondrial DNA and disease by Johns (Sept. 7 issue)¹ ended with the assumption that the American cyclist Greg LeMond retired in 1994 because of a “mitochondrial myopathy.” The ...

To the Editor: Brugger and coworkers (Aug. 3 issue)¹ suggest that CD34+ hematopoietic progenitor cells expanded ex vivo rapidly reconstitute hematopoiesis after high-dose chemotherapy (1500 mg of etoposide per square meter of body-surface area, 12 g of ...

To the Editor: Moore et al. (May 4 issue)¹ found herpesvirus-like DNA sequences in Kaposi's sarcoma lesions, both in patients infected with the human immunodeficiency virus (HIV) and in HIV-seronegative patients.¹ In the same issue, Cesarman and ...

To the Editor: Human ehrlichiosis is increasingly being recognized as a cause of a diverse spectrum of illness in geographic regions where the tick vectors are found. The New York State Department of Health recently alerted physicians about human ...

To the Editor: The Centers for Disease Control and Prevention recently noted that rheumatic fever is among 10 diseases that have been removed from the list of nationally notifiable diseases.¹ Although this decision may be appropriate at the national ...

To the Editor: I am writing in response to Frankel's article on recovered memories (Aug. 31 issue).¹ Although I was severely abused physically and sexually throughout my early childhood — abuse later confirmed by family members — I had absolutely no ...

A remarkable triumph of modern medicine is the cure of most forms of childhood cancer. By the turn of the century, it is estimated that 1 in 900 persons between 21 and 45 years of age will be a survivor of childhood cancer. The defining event that ...

In caring for critically ill children, the demands on one's time are great, and there is often little time left for reading. Although there are a number of excellent, comprehensive books on pediatric critical care that must be read by those in the field, ...

The authors of this concise textbook on pediatric trauma have followed closely the format of the manual of the Advanced Trauma Life Support course produced by the American College of Surgeons. Since trauma is the most common cause of death and disability ...

This useful book, packed full of clinical information, is a timely update of earlier books on pediatric cerebrovascular disorders. The text is presented in a straightforward, easily readable fashion, with many well-designed tables, some clinical ...