Crohn's disease is characterized by remission and relapse. The relapses are most likely to occur soon after patients enter remission and are more frequent in those with abnormalities in serum concentrations of acute-phase proteins.¹–³ Because fish oil has ...

The chemoprevention of cancer is one of the most challenging aspects of medical research.¹–⁵ Primary chemoprevention addresses a general population or a population at particularly high risk, such as long-term smokers. By contrast, secondary ...

Lesch–Nyhan disease, a rare X-linked recessive disorder of purine synthesis, is characterized by the virtual absence of hypoxanthine–guanine phosphoribosyltransferase (HPRT), one of the major enzymes of the salvage pathway of purine synthesis. The ...

Drug-resistant tuberculosis has become a major public health problem in the United States.¹,² In 1979 less than 1 percent of tuberculosis isolates from untreated patients in New York City were resistant to rifampin, as compared with 9 percent in 1991.³ ...

Figure 1. A portion of a polysomnogram recorded in a neonate with congenital hydrocephalus and resultant periodic breathing shows frequent, short periods of central apnea, as demonstrated by the cessation of oronasal air flow and the absence of a wave ...

In critical care units and hospital wards across the country, patients and physicians struggle with decisions about whether or not to undertake cardiopulmonary resuscitation (CPR) and other potentially life-sustaining treatment. Often, these decisions are ...

In the past two years, three new antiepileptic drugs — gabapentin, lamotrigine, and felbamate — have been approved for use in the United States. They are the first such drugs to be approved since valproic acid, in 1978. These three drugs and others now in ...

Presentation of Case

A newborn boy was admitted to the hospital because of a rash and respiratory distress.

The infant was born at 3:35 p.m. by cesarean section at 34 weeks' gestation to a 37-year-old woman (gravida 3, para 2). The pregnancy had been ...

Fifteen years ago, after the National Cooperative Crohn's Disease Study (NCCDS)¹ had found that patients in remission who were given placebo fared better than those given corticosteroids, azathioprine, or a 5-aminosalicylate–sulfonamide compound, the ...

In this issue of the Journal, Muto et al.¹ report a decrease in the incidence of second primary hepatocellular carcinomas in patients treated with polyprenoic acid, an acyclic retinoid, after the resection or ethanol ablation of small, solitary primary ...

Since first described 32 years ago, Lesch–Nyhan disease has caught the imagination of clinicians and scientists,¹ largely because of the intriguing fact that a precise metabolic error produces a complex set of clinical manifestations. Particularly ...

One of the most popular shows on television this year is ER, a Chicago-based drama that depicts the professional and personal lives of medical students, residents, and attending physicians working in the emergency department of an inner-city public ...

To the Editor: The article by Hunter et al. (Feb. 8 issue)¹ wrongly implies that lowering the total intake of fat in midlife does not reduce the risk of breast cancer.

They reanalyze seven prospective studies in which the dietary fat intake was not low ...

To the Editor: My colleagues and I reported (Jan. 18 issue) that HemeSelect and a combination test in which HemeSelect is used to confirm positive Hemoccult II Sensa results are an improvement over Hemoccult II in screening patients for colorectal ...

To the Editor: Many studies have shown amplification of the N-myc oncogene to be a highly reliable predictor of death from neuroblastoma.¹–³ Caron et al. (Jan. 25 issue)³ report that allelic loss of chromosome 1p is a more powerful predictor of ...

To the Editor: On the basis of data collected from the Coronary Artery Surgery Study (CASS) registry, Cameron and coworkers (Jan. 25 issue)¹ conclude that as compared with saphenous-vein coronary bypass grafts, internal-thoracic-artery (ITA) grafts ...

To the Editor: Deficiency of the dystrophin-associated protein adhalin has been associated with autosomal recessive muscular dystrophy. The report by Fadic et al. (Feb. 8 issue)¹ advances our understanding of the dystrophin complex by identifying a child ...

To the Editor: Bennett et al. (Jan. 11 issue)¹ further document the increasing prevalence of parkinsonism as people age. However, parkinsonism is not Parkinson's disease, and we fear that the two may be confused.

Although the diagnosis of Parkinson's ...

To the Editor: The data submitted for the approval of metformin for use in the United States were from two 29-week clinical trials involving patients with non-insulin-dependent diabetes mellitus (NIDDM), reported by DeFronzo et al. (Aug. 31 issue),¹ and ...

Having trained at a medical school where the ophthalmology and dermatology departments were strongly oriented toward internal medicine and where many faculty members in these departments were able to diagnose and treat systemic diseases, I quickly ...

Since the birth of immunology in the late 1800s, physicians interested in the eye have recognized the importance of identifying immunologic mechanisms to the understanding of ocular disorders. The editors of Ocular Infection and Immunity provide an ...

In most textbooks of otolaryngology or otology the external ear receives short shrift, with coverage of its wide variety of medical and surgical problems crammed into a short chapter. The External Ear stands in sharp contrast. Over 300 pages of text and ...

Although the function of the paranasal sinuses remains unknown, we know that they are susceptible to disease and a major cause of misery for patients. The influence of sinusitis on health is only beginning to be recognized. It is estimated that 30 million ...

Case Records of the Massachusetts General Hospital (Case 9-1996) Case Records of the Massachusetts General Hospital, N Engl J Med 1996:334;784-789.. On page 784, five lines from the bottom of the left-hand column, the phrase should have read, “with ...

Induction of Labor Compared with Expectant Management for Prelabor Rupture of the Membranes at Term Original Article, N Engl J Med 1996:334;1005-1010.. On page 1006, in Table 1, the third entry in the leftmost column should have read, “Interval from ...