The discovery of hepatitis C virus (HCV)¹ was a major step toward the control of non-A, non-B hepatitis.² HCV is responsible for the majority of acute and chronic cases of non-A, non-B hepatitis,³ and the screening of blood for antibodies against HCV (...

Human cytomegalovirus (CMV) is an important pathogen in persons with the acquired immunodeficiency syndrome (AIDS), and at autopsy as many as 90 percent of patients with AIDS have evidence of CMV infection.¹–⁵ CMV retinitis affects 25 to 40 percent of ...

Clinical factors used to predict whether patients who come to an emergency department with acute chest pain are having an acute myocardial infarction or have acute ischemic heart disease¹–⁷ serve as surrogate criteria for another important issue: deciding ...

Neuroblastomas are the most common extracerebral solid tumors of infancy and childhood. These embryonal tumors of the sympathetic nervous system are unique among pediatric tumors because of their biologic complexity. Neuroblastoma is often lethal, but up ...

Figure 1. A 36-year-old man had painless, intermittent loss of vision. In this photograph, a hypopyon, or leukocytic exudate, is seen in the anterior chamber (arrow) of the eye, and the conjunctiva and the underlying episclera appear injected. These ...

This is the story of the controversy over the safety of silicone-gel–filled breast implants — a controversy that has raged in this country for nearly a decade and is still not resolved. It is a story fascinating in itself, but one particularly worth ...

Hip fractures, particularly in older persons, result in problems that extend far beyond the orthopedic injury, with repercussions in the areas of medicine, rehabilitation, psychiatry, social work, and health care economics. There are over 250,000 hip ...

A diverse system of adhesion molecules and adhesion receptors participates in orchestrating vital biologic phenomena, such as embryogenesis, cell growth and differentiation, and wound repair. Over the past decade there has been immense progress in our ...

Stage

A 52-year-old man was brought to the hospital because of lethargy and headache. He had a history of mild, intermittent headaches and heartburn but had had worse-than-usual occipital and left retro-orbital pain for the past one or two days. There was ...

The cloning of the hepatitis C virus (HCV)¹ established that important human pathogens, which could not be seen microscopically, grown in cell culture, or detected serologically, could nonetheless be discovered through the power of molecular ...

Neuroblastoma is the most enigmatic of neoplasms of children because of its variable clinical behavior: it may regress spontaneously in infants, mature into a benign ganglioneuroma in older patients, or grow relentlessly and be rapidly fatal.¹ ...

Do people infected with the human immunodeficiency virus (HIV) have special responsibilities to their sexual partners? If so, what do these responsibilities involve? Merely raising these questions directly has tended, until recently, to disquiet many ...

To the Editor: Emmerson's review of the management of gout (Feb. 15 issue)¹ contains much useful information, but it also includes several arguable points. In their classic studies Gutman and Yü found that the excretion rate of urate in patients with ...

To the Editor: Considine and coworkers (Feb. 1 issue)¹ report that obese subjects have elevated serum leptin concentrations that decrease during weight reduction. The authors conclude that “most obese persons are insensitive to endogenous leptin ...

To the Editor: The article by Gill et al. (Jan. 11 issue),¹ on the prognostic value of ambulatory electrocardiographic (ECG) monitoring early after myocardial infarction, concludes that the detection of ischemia during a 48-hour period was the best ...

To the Editor: The Trandolapril Cardiac Evaluation (TRACE) study (Dec. 21 issue),¹ a multicenter study of patients with left ventricular systolic dysfunction after myocardial infarction, showed a clear benefit of long-term treatment with trandolapril, an ...

To the Editor: As a participating observer at the International Symposium on Pertussis Vaccine Trials, I was surprised to read the following statement in the editorial by Edwards and Decker (Feb. 8 issue)¹: “All the acellular vaccines evaluated in the ...

To the Editor: In Case Record 4-1996, the discussion by Liu and Compton (Feb. 8 issue)¹ of a patient with paralysis due to schistosomiasis deserves comment on two points.

The first concerns Dr. Liu's final sentence, which states that there is “evidence ...

To the Editor: A new group of Flaviviridae viruses — hepatitis GB virus C (HGBV-C)¹ and hepatitis G virus (HGV)² — has recently been described. Patients infected with these viruses have persistent viremia, and they may have chronic hepatitis.

We tested ...

Medical students, eye-care specialists in training, and practicing ophthalmologists should welcome The Eye: Basic Sciences in Practice. John Forrester and colleagues have successfully integrated state-of-the-art basic-science principles with abundant ...

The fact that most diseases of the eye produce visible changes in the organ means that a really good pictorial atlas of ophthalmic disease is essential. This extensive collection of photographs of ophthalmic diseases and their histologic correlates is a ...

This handsome set of books on glaucoma provides a comprehensive description of the state of the art. This second edition builds on the strengths of the first edition. I looked particularly at volume 3, Glaucoma Therapy. The book begins with a section on ...

The Retina Atlas confirms the adage that a picture is worth a thousand words. This remarkable textbook has relatively few words but nearly 1700 beautiful color pictures, illustrating an array of disorders that can affect the retina. Retinal disease is a ...

Since its first publication in 1989, Uveitis: Fundamentals and Clinical Practice has been the preeminent textbook of clinical ocular immunology. The extensively rewritten second edition includes a third author (Dr. Whitcup) and an excellent new selection ...

This small textbook seeks to bridge the fields of pediatrics and neuro-ophthalmology. It reflects the three authors' distinctive approaches to their subject and, like many multiauthored compendiums, reads like a series of authoritative monographs. This ...

This book takes a multidisciplinary approach to disorders of the lacrimal system. The material for the book was gleaned from the editor's experience in a multispecialty, multidisciplinary lacrimal unit at Mount Sinai Hospital in Toronto. This facility ...