A 1993 investigation of a flight attendant with infectious tuberculosis demonstrated transmission of the disease to other crew members, but evidence of transmission to passengers was inconclusive.¹ In June 1994, a state health department notified the ...

In animals with experimentally induced renal disease, drugs that inhibit angiotensin-converting enzyme reduce glomerular-capillary pressure, inhibit renal cellular growth, and reduce glomerular-capillary permeability to protein, thus reducing proteinuria ...

Cerebral cavernous malformation is a vascular disorder of the brain characterized by abnormal vascular spaces lined by a single layer of endothelium without intervening neural parenchyma or identifiable mature vessel-wall elements.¹,² There is almost ...

Insulin resistance and hyperinsulinemia are conditions known to be associated with hypertriglyceridemia and low high-density lipoprotein (HDL) cholesterol concentrations.¹,² Four prospective studies, in which fasting plasma insulin concentrations were ...

Figure 1. A 13-year-old boy presented with increasing kyphotic deformity, back pain, and progressive paraparesis seven years after a one-year course of medical therapy for tuberculosis. He reported shock-like sensations in his legs whenever he bent ...

A substantial gap between the earnings of male and female physicians was identified in the mid-1970s.¹ Later studies confirmed that male physicians earned more than female physicians, even after adjustment for differences in the number of hours worked, ...

During the 20th century, there have been recurrent episodes of cocaine abuse in the United States that have achieved epidemic proportions.¹ Although the total number of people using the drug has decreased in the past decade, cocaine-related biomedical and ...

Presentation of Case

A 69-year-old man was admitted to the hospital because of increasing dyspnea in the course of one day. The patient had a 12-year history of hypertension. He had had hyperlipidemia, with pancreatitis, five years before admission. ...

Our fascination with the misadventures of travel dates back to the dawn of recorded history. Homer's epic tale of the 10-year wanderings of Odysseus returning home to Ithaca after the fall of Troy remains the classic account of journey-related hazards. ...

The role of women in our society has been changing rapidly over the past two or three decades. Nowhere is this trend more striking than in medicine. Women constitute over 40 percent of the student body in medical schools today, in contrast to less than 10 ...

Olestra, a polyester of sucrose and six or more triglycerides, was approved by the Food and Drug Administration (FDA) on January 24 as a nondigestible substitute for fat in snack foods, after a long review of the petition from its manufacturer, Procter & ...

To the Editor: Dr. Bailar (Nov. 30 issue)¹ reassures physicians and patients that the lumpectomy study findings of the National Surgical Adjuvant Breast and Bowel Project (NSABP) are credible. However, he asserts that until a much broader analysis of the ...

To the Editor: It is useful to be reminded of the hypothesis that Fisher et al. were testing when they compared lumpectomy alone with lumpectomy plus radiation in the NSABP Protocol B-06 trial (Nov. 30 issue).¹ Fisher et al. articulate two divergent ...

To the Editor: I wish to propose some alternative ways to group patients and trials in the analysis of radiotherapy and surgery in early breast cancer, reported by the Early Breast Cancer Trialists' Collaborative Group (Nov. 30 issue).¹

The studies ...

To the Editor: In the report by Philip et al.¹ (Dec. 7 issue), there are several shortcomings in the Parma Group's comparison of high-dose chemotherapy and autologous bone marrow transplantation with conventional salvage chemotherapy for patients with ...

To the Editor: The virtual elimination of the risk of transmitting the human immunodeficiency virus (HIV) by the transfusion of screened blood is a triumph of transfusion medicine, as the analysis by Lackritz et al. (Dec. 28 issue)¹ shows. Remarkably ...

To the Editor: Strategies to prevent congenital toxoplasmosis remain controversial. In France, all pregnant women who are seronegative for antibodies to Toxoplasma gondii are tested monthly for toxoplasmosis despite the lack of evidence of the cost ...

To the Editor: Robert Schwartz, in his review of Arthur Kornberg's book The Golden Helix: Inside Biotech Ventures (Nov. 9 issue),¹ chastises faculty members for seeking personal profit from connections with industry formed through biotechnology ventures ...

In 1981, a study of the role of primary care physicians concluded that there was a lack of consensus about many of the surgeon general's recommendations for health promotion and that most primary care physicians felt unprepared for this role and unable to ...

Our understanding of pathophysiology, diagnosis, and treatment in all areas of hematology is evolving at a fast pace. Updated textbooks therefore meet a vital need of academic and private hematologists. To accommodate these advances, new editions of a ...

Throughout the world, a large proportion of all transfused blood is given to patients undergoing surgery. Responsibility for decisions about transfusion therapy during surgery frequently falls to the person in charge of the patient's anesthesia and life ...

Effects of Radiotherapy and Surgery in Early Breast Cancer — An Overview of the Randomized Trials Original Article, N Engl J Med 1995:333;1444-1456.. On pages 1447 and 1450, in Figure 2, 4, and 5, the labels, “Odds reduction,” should have read, “...