Erectile dysfunction, the consistent inability to attain and maintain a penile erection sufficient to permit satisfactory sexual intercourse, may affect 20 million to 30 million American men.¹,² It impairs men's mental well-being and interactions with ...

Focal segmental glomerulosclerosis develops and progresses to renal failure in some patients who have idiopathic nephrotic syndrome that is resistant to treatment with corticosteroids and cytotoxic drugs.¹–³ After transplantation, up to 40 percent of such ...

Rates of mortality from coronary heart disease (CHD) in the United States, adjusted for age, have declined since the mid-1960s.¹ During the 1980s, the annual rate of that decline was about 3.5 percent for both men and women.² CHD nonetheless remains the ...

Figure 1. A 35-year-old man who had smoked two packs of cigarettes per day for 20 years presented with necrosis of the ends of the middle finger and the thumb of the left hand. These lesions had been preceded for three to four years by burning sensations ...

In a 1992 report,¹ the Council on Graduate Medical Education concluded that deficiencies in the physician work force, the medical-education system, and public policy would hinder efforts to provide high-quality and affordable health care for all people in ...

Autoimmune hepatitis is a chronic necroinflammatory liver disorder of unknown cause associated with circulating autoantibodies and a high serum globulin level. Since the first descriptions of the disorder in the 1950s, it has been known by a variety of ...

The ability to remove or alter with precision a single one of the thousands of genes in the body and to transmit this mutation to all subsequent progeny was a science-fiction dream only a few years ago. But today this technique is part of a routine ...

Stage

A 79-year-old woman who had a three-month history of near-syncopal episodes associated with transient confusion and slurred speech was admitted to the hospital. Her son, an emergency medical technician, noted a rapid irregular pulse during one ...

In this issue of the Journal, Linet and Ogrinc report that intracavernous-injection therapy with alprostadil (a synthetic prostaglandin E₁) can produce good results in men with erectile dysfunction (impotence).¹ It should be emphasized that the proper ...

The study of renal allografts has provided insight into the pathogenesis of renal diseases.¹ In patients with some disorders, such as Liddle's syndrome (in which long-standing hypertension may severely impair renal function), kidney transplantation cures ...

When I was an intern in a New York City hospital in the late 1960s, a pay increase for house staff brought our salaries to $4,500 a year. I can remember how my chief of service reacted. “It used to be,” he groused, “that all you needed to hire interns and ...

To the Editor: In the case of the 22-year-old Laotian immigrant described in the Clinical Problem-Solving article entitled “If at First You Don't Succeed” (Dec. 7 issue),¹ does the one-year interval between the first medical consultation and the complete ...

To the Editor: Folkman's article on angiogenesis (Dec. 28 issue)¹ focused on clinical applications, with particular emphasis on the treatment of cancer. There is evidence that angiogenesis is indeed a factor in the progression of human carcinoma, but the ...

To the Editor: Roujeau et al. (Dec. 14 issue)¹ present data showing a morbidity of 1 in 230,000 associated with toxic epidermic necrolysis and the Stevens–Johnson syndrome due to one week of trimethoprim–sulfamethoxazole therapy. If the death rate is ...

To the Editor: Meyer zum Büschenfelde and Lohse (Oct. 12 issue)¹ suggest that patients with mild autoimmune hepatitis should be treated. However, few data support the contention that such patients will benefit. Although the results of large controlled ...

To the Editor: It has become increasingly clear that insufficient sleep and disrupted circadian rhythms are a major public health problem. For instance, in 1988 the cost of sleep-related accidents exceeded $56 billion and included 24,318 deaths and 2,474,...

“Textbook” is defined variously as “a book for regular study by pupils, especially as an authority and standard in a particular subject,” or as a “book giving instructions in the principles of study.” In general, the books we call textbooks have blurred ...

This is one of two books published within the past year in the area of occupational neurology, giving potential readers a broad spectrum of views in both classically described and more controversial work-related conditions of the nervous system. This book ...

Although they were integrated in the early days of clinical medicine, psychiatry and neurology diverged substantially over the past half-century into distinct fields, one involved with psychopathology (disease of the mind) and the other involved with ...

Most comprehensive textbooks that attempt to deal with a complex clinical problem require contributions from multiple authors. Often, this results in duplication of material, disjointed information, poor organization, and an unreadable product. In Nerve ...

Electrocardiographic Diagnosis of Evolving Acute Myocardial Infarction in the Presence of Left Bundle-Branch Block Original Article, N Engl J Med 1996:334;481-487.. On page 484, in Figure 2, the first question in the flow chart should have read, “Is there ...