Long-term sequelae of the treatment of Hodgkin's disease are being encountered with increasing frequency because of the marked improvement in survival.^1-4 Second neoplasms, particularly acute myelogenous leukemia, are well-known late complications in ...

Variants of the apolipoprotein E gene appear to account for the majority of cases of late-onset Alzheimer's disease (i.e., those involving the onset of dementia after the age of 60).¹–⁷ The gene, located on chromosome 19, has three major alleles: ε2, ε3, ...

Mild hyperhomocysteinemia is an established risk factor for atherosclerosis and vascular disease.¹,² In classic homocystinuria, half the vascular complications are of venous origin,³ but until recently it has been unclear whether mild hyperhomocysteinemia ...

Homocystinuria is caused by deficient activity of one of several enzymes in methionine metabolism, either as a primary defect or as a result of defects in the cytosolic metabolism of cobalamin.¹–⁴ Hyperhomocysteinemia can also be due to a deficiency of ...

Figure 1. A 28-year-old woman with a 10-year history of systemic lupus erythematosus presented with fever, back pain, and bilateral paresthesias and weakness of the legs of 10 days' duration. She had been taking prednisone for the preceding nine months ...

Listeria monocytogenes, an aerobic and facultatively anaerobic gram-positive bacillus, can be readily isolated from soil, dust, fertilizer, sewage, stream water, plants, and even processed foods stored at 4°C. The organism is also present in the ...

Non-insulin-dependent diabetes mellitus (NIDDM), the commonest form of diabetes, affects approximately 5 percent of the population of the United States. Although the pathophysiology of this condition has not been fully characterized and the nature of the ...

Presentation of Case

A 21-year-old woman was admitted to the hospital because of thoracolumbar pain.

The patient had been well until 17 weeks earlier, when she began to have pain in the midline thoracolumbar region of the spine, with radiation to the ...

After a certain age, when people forget something they may say jokingly, Is this the first sign of dementia? Some may laugh, but the laughter is uncomfortable. Dementia is too common. Everyone wonders, could it happen to me? In the developed world most ...

The treatment of Hodgkin's disease is a model of successful therapy for childhood cancer, with cure rates of over 90 percent expected from chemotherapy regimens and low-dose radiation (15 to 25 Gy) to involved regions.¹ The current therapy evolved to ...

Old age is a territory populated largely by women. Because women outlive men by an average of seven years, the ratio of women to men increases sharply among the elderly. For every 100 men 65 years of age and older, there are about 150 women. By the age of ...

To the Editor: The purpose of active management of labor, as developed over a period of years during the 1960s at the National Maternity Hospital in Dublin, Ireland, was to enhance the quality of the experience of childbirth by preventing prolonged labor ...

To the Editor: In their prospective, multicenter trial, Gattinoni and colleagues (Oct. 19 issue)¹ evaluated the effects of increasing the cardiac index to a supranormal level or increasing mixed venous oxygen saturation to a normal level on the survival ...

To the Editor: The report by Giovannucci et al. (Sept. 7 issue)¹ documenting a chemopreventive effect of aspirin against the development of colorectal cancer in women adds evidence to the already abundant data strongly suggesting that nonsteroidal ...

To the Editor: Descriptions of infants with reported clearance of human immunodeficiency virus (HIV) infection are both provocative and of some concern.¹–³ They raise a number of scientific questions that are difficult to answer on the basis of our ...

To the Editor: Rees et al. (Nov. 23 issue)¹ suggest that Campylobacter jejuni infection has a role in the development of Guillain–Barré syndrome. Their microbiologic and serologic data show evidence of recent C. jejuni infection in 26 percent of their ...

To the Editor: In the study by Bosma et al. (Nov. 2 issue)¹ of the genetic basis of Gilbert's syndrome, the relevance of the variant TATAA element is far from certain. The authors do not provide data or cite references that demonstrate that a ...

To the Editor: In their article on the epidemiology of Lyme disease in southern Sweden, Berglund et al. (Nov. 16 issue)¹ stated that borreliosis is not a notifiable disease in any European country. We would like to correct this statement. Notification of ...

The introduction of a new “comprehensive handbook” stirs up curiosity and expectation among clinicians striving to keep pace with the rapidly evolving world of diet, body image, eating disorders, and obesity. Epidemiologists advise us that up to a third ...

This is an odd book. The editors, a professor of pathology and a professor of radiology, have not written a history of gastroenterology but have collected 21 already published essays (dating from 1960 to 1988) to take “a backward look” at the emergence of ...

The stated goal of this large textbook is “to provide a comprehensive source that combines the scientific basis and the art of medicine, relevant to enteric infections.” To accomplish this goal, the editors enlisted a diverse group of authorities to write ...

This multiauthored British textbook is the first in a series that will review techniques of quantitative measurement in medicine. The quality of the printing, binding, black-and-white photos, and line drawings is very good. The book includes a single ...

Impaired Processing of Prohormones Associated with Abnormalities of Glucose Homeostasis and Adrenal Function Original Article, N Engl J Med 1995:333;1386-1391.. On page 1387, in Figure 1, in the Minor Pathway, the left side of the proinsulin molecule ...

Hematopoietic Reconstitution with Autologous Stem Cells Correspondence, N Engl J Med 1996:334;271-272.. On page 271, the sentence that begins in line 14 of the right-hand column should have read, “The curves for absolute neutrophil and platelet counts in ...