Patients with acute proximal deep-vein thrombosis are usually treated initially in the hospital with standard (unfractionated) heparin, administered by continuous intravenous infusion for five to seven days.¹ The anticoagulant response to this treatment ...

Anticoagulant treatment for deep-vein thrombosis aims to prevent pulmonary embolism and recurrent thrombosis and also to avoid excessive bleeding.¹ In addition, both the effect of therapy on the patients' well-being and the cost of therapy are factors to ...

Allergies to nuts are among the most common food allergies,¹ and allergies to the Brazil nut are well documented.² Concern has been expressed about the introduction of allergenic proteins into food plants by genetic engineering.³–⁵ The Food and Drug ...

The value of orthotopic liver transplantation in the treatment of hepatocellular carcinoma has often been debated. Although liver replacement could be curative for patients with tumors confined to the liver, the long-term results of liver transplantation ...

Figure 1. A chest x-ray film (Panel A) in a 41-year-old man with human immunodeficiency virus infection who had a four-month history of fever, cough, and worsening dyspnea showed a diffuse, bilateral reticulonodular pattern. A blood smear (Panel B; Wright-...

Many practicing physicians have received no formal training in the care of patients infected with the human immunodeficiency virus (HIV). Moreover, because standards of care for the acquired immunodeficiency syndrome (AIDS) change rapidly, primary care ...

The female steroid hormones, estrogen and progesterone, are prescribed widely by physicians, and their risks and benefits have been studied extensively. Although androgen preparations have been available for many years, most clinicians are less familiar ...

Presentation of Case

A 28-year-old woman was admitted to the hospital because of the rapid development of a major personality change and global aphasia.

The patient had been well until one month earlier, when she reported an intermittent toothache in the ...

Institutions that have been longtime rivals are merging. In Massachusetts, Brigham and Women's Hospital and the Massachusetts General Hospital have merged, and two of the state's largest health maintenance organizations (HMOs) — Harvard Community Health ...

Venous thromboembolism, a disease now recognized in most cases to have a genetic basis,¹ is the discharge diagnosis of more than a quarter-million patients in U.S. hospitals annually.² Heparin has been the standard initial therapy for this condition since ...

Food biotechnology, the use of recombinant-DNA and cell-fusion techniques to confer selected characteristics on plants and animals used for food,¹ can be used to increase agricultural productivity. The great promise of biotechnology is that the use of ...

Many factors influence the survival of patients with hepatocellular carcinoma, quite apart from treatment, the most important being the size of the tumor at the time of diagnosis and the severity of the underlying cirrhosis.¹ Small hepatocellular ...

A wide spectrum of specialists and generalists are now delivering care of increasing complexity for patients infected with the human immunodeficiency virus (HIV). Few of these physicians have had any formal training in what is, in many respects, a new ...

To the Editor: The study of overweight and mortality in women (Sept. 14 issue)¹ by Manson and colleagues arrives at some conclusions that may complicate the treatment of women with eating disorders, who are already obsessed with the absolute value of ...

To the Editor: The study by Liberman et al. (Nov. 30 issue)¹ on the effects of alendronate on bone mineral density and the incidence of fractures in postmenopausal women with osteoporosis is important, but in our view not as exciting as it first seems. ...

To the Editor: Frigo and Lang (Nov. 30 issue)¹ describe an ancient skeleton of a 45-year-old woman as osteoporotic on the basis of the bone mineral density at the femoral neck (0.831 g per square centimeter). This value, however, was only 1 SD below the ...

To the Editor: The study by Brochard et al. (Sept. 28 issue)¹ showed an impressive decrease in the need for endotracheal intubation in patients with acute exacerbations of chronic obstructive pulmonary disease treated with noninvasive positive-pressure ...

To the Editor: Using molecular evidence, Hamilton et al. (March 30 issue)¹ defined two germ-line defects associated with Turcot's syndrome, one of which is usually found in hereditary nonpolyposis colorectal cancer, and the other of which is usually ...

To the Editor: In their study of the effect of utilization review in a fee-for-service health insurance plan (Nov. 16 issue),¹ Rosenberg et al. found a reduction in the number of diagnostic and surgical procedures performed that required second opinions, ...

In the Draft Constitution of the Russian Federation, prepared in 1992, Article 37(3) states, “Concealment by state officials of facts and circumstances that present a threat to human life and health shall be amenable under the law.” This reflects a ...

The profound social effects of tuberculosis in Europe and America are familiar. The epidemic began about 1800, as urban crowding associated with the Industrial Revolution increased, and it leveled off as living conditions improved early in the 20th ...

When I first picked up Disease and Class: Tuberculosis and the Shaping of Modern North American Society, the title led me to expect a polemic on capitalistic exploitation and repression of the working classes and the resultant epidemic of urban ...

Power is an enticing topic, and the abuse of power a fascinating one. Anton Neumayr is a specialist in internal medicine who lives and works in Vienna. He is also a concert pianist, a writer on European composers of the 18th and 19th centuries (his ...

New Rules describes, and then proposes a solution to, an emerging conundrum in health care: changes in financial incentives and organizational structures are producing new threats to health care quality, yet existing public and private quality-assurance ...

Noninvasive Ventilation for Acute Exacerbations of Chronic Obstructive Pulmonary Disease Original Article, N Engl J Med 1995:333;817-822.. On page 821, in Table 4, the totals in the Standard Treatment group should have been 23 for “no. of complications” ...

Case Records of the Massachusetts General Hospital (Case 35-1995) Case Records of the Massachusetts General Hospital, N Engl J Med 1995:333;1340-1346.. On page 1341, in Table 1, the first two entries should have read, “Forced first-second vital capacity (...