Methods for the medical termination of pregnancy, as an alternative to surgical termination, have been available in Europe and China for more than five years. In France,¹,² 46 percent of women seeking abortions preferred medical termination with ...

In the United States patients with non-insulin-dependent diabetes mellitus (NIDDM) are usually treated with diet and a sulfonylurea drug.¹ However, approximately 30 percent of patients initially treated with a sulfonylurea drug have a poor response, and ...

The metabolic abnormalities of non-insulin-dependent diabetes mellitus (NIDDM) are generally acknowledged to result from a combination of insulin resistance and impaired insulin secretion.¹ Since 1975, when the biguanide phenformin was withdrawn from the ...

Acute bleeding from esophageal varices is a major problem in patients with cirrhosis of the liver and is associated with a 30 to 50 percent risk of death.¹–³ Sclerotherapy is considered the most effective way to stop bleeding and is the main form of ...

Vaccination with bacille Calmette-Guérin (BCG), an attenuated strain of Mycobacterium bovis, has been used extensively throughout the world as immunoprophylaxis against tuberculosis. Since 1976, intravesical administration of BCG has been used to treat ...

Figure 1. A 45-year-old woman with poorly controlled insulin-dependent diabetes mellitus had facial and periorbital swelling for three to four days. On the day of admission she was unable to open her right eye (Panel A). On admission she had a white-cell ...

Each year, more than a million coronary angiography procedures, approximately 400,000 angioplasties, and 400,000 coronary-artery bypass operations are performed in the United States.¹ Coronary artery disease is highly prevalent, and its management often ...

There are substantial geographic differences in the rates at which patients with cardiac disease undergo diagnostic procedures and treatments, but there is little evidence that these variations are related to survival.¹–⁶ Although studies of such ...

Presentation of Case

A 29-month-old girl was readmitted to the hospital because of increasing ataxia and abnormal eye movements.

The child had been born after a 30-week gestation, with a birth weight of 1.35 kg. The mother was reported to have abused ...

We now have another drug for the treatment of patients with non-insulin-dependent diabetes mellitus (NIDDM). After more than a decade of clinical experience in Europe, Canada, and other countries,¹,² the Food and Drug Administration (FDA) has approved ...

For more than 20 years, investigators have documented substantial variation in the use of medical and surgical procedures, hospital resources, and medications at both the regional and international levels.¹–³ From this research we have learned that the ...

Recently the traditional reflective approach in psychotherapy has been challenged by a confrontational stance on behalf of patients. As a result, the place of truth and the validity of long-delayed memories of abuse in childhood have become the focus of a ...

To the Editor: Inaccuracies in our paper “Interferon Alfa-2a Therapy for Life-Threatening Hemangiomas of Infancy”¹ prompted a careful review. On the basis of our reanalysis and an interim review by a standing faculty committee of the Harvard Medical ...

To the Editor: Bonadonna et al. (April 6 issue)¹ addressed the effect of drug-induced amenorrhea on the outcomes of 78 premenopausal patients treated with cyclophosphamide, methotrexate, and fluorouracil (CMF) (Table 2 of the article). In 50 patients who ...

To the Editor: Olivieri et al. (April 6 issue)¹ are to be congratulated on their work on deferiprone, which, in addition to demonstrating the drug's efficacy in iron chelation, is the only study so far to have addressed some of the controversies ...

To the Editor: The serologic survey by Gergen et al. (March 23 issue)¹ corroborates earlier studies showing that more than half of Americans over the age of 50 lack what are considered protective levels (>0.15 IU per milliliter) of tetanus antitoxin. ...

To the Editor: Feagan et al. (Feb. 2 issue)¹ found that in a group of patients with chronically active Crohn's disease, methotrexate was more effective than placebo in improving symptoms and reducing requirements for prednisone. Further discussion is ...

To the Editor: Octreotide, a long-acting analogue of somatostatin, is effective therapy for patients with thyrotropin (TSH)-secreting pituitary adenomas.¹ A 31-year-old infertile woman with hyperthyroidism caused by a TSH-secreting macroadenoma was ...

To the Editor: Professor Housman's article (Feb. 23 issue)¹ succinctly covers many of the issues in the use of DNA typing in forensic settings. The movement of this method from research contexts to courtrooms has been rapid and controversial and has ...

To the Editor: Davis and Gregerman (April 6 issue)¹ provided a useful update of parse analysis but either neglected several important issues or, more likely, saved them for a subsequent article. First, nu was not defined mathematically, leaving it ...

This book is an outstanding new contribution to the literature. Even its title, Electrodiagnostic Medicine, exemplifies the author's contemporary and comprehensive approach to the medical specialty of electrodiagnosis. Going well beyond the usual books on ...

Thirty years have elapsed since C.K. Meador proposed the concept of nondisease in the Journal (“The Art and Science of Nondisease.” 1965;272:92-5). He suggested that when a specific disease is suspected but not found, the patient has a particular ...

At first glance, this book seems to be drowning in a sea of minutiae. There is an entire page devoted to the semantic differences between “idiopathic” and “cryptogenic” epilepsy. But it soon becomes apparent that the attention to detail in this book is ...

This book represents a timely and ambitious effort to integrate knowledge from a variety of fields about the neuropsychiatric assessment and treatment of brain-injured patients. Although there are a number of books on traumatic brain injury, this unusual ...

A number of sports-medicine textbooks are available, but none has achieved the right balance of breadth and depth to be recognized as the reference work in this field. Many of these textbooks have focused on the musculoskeletal system as the center of the ...

Case Records of the Massachusetts General Hospital (Case 23-1995) Case Records of the Massachusetts General Hospital, N Engl J Med 1995:333;241-248.. Because of a printing problem, the colors in Figure 4, 5, 6, and 7 on page 246 of the domestic edition do ...