Evidence of unexpectedly high rates of survival of kidney grafts from spouses and other living unrelated donors in patients with end-stage renal disease has been mounting in recent years.¹–⁹ Although most transplants from living unrelated donors are ...

Sudden death in a young athlete is a dramatic event that has attracted considerable attention.¹ Most such catastrophes have been shown to be the consequence of unsuspected congenital or acquired cardiovascular disease.²–¹² However, we attempted to expand ...

Non-insulin-dependent diabetes mellitus (NIDDM) is one of the most common inherited diseases, with an estimated prevalence of 8 to 10 percent among whites.¹ Although most forms of the disease do not have a simple mendelian pattern of inheritance, the ...

Resistance to insulin in skeletal muscle has often been attributed to concomitant obesity, particularly abdominal obesity,¹–⁵ and associated with glucose intolerance, hypertension, and dyslipidemia.⁶ Whether abdominal obesity leads to insulin resistance ...

Both environmental and genetic factors are involved in the onset and progression of weight gain.¹ Morbid obesity in humans (body-mass index [the weight in kilograms divided by the square of the height in meters], >40) appears to have a particularly strong ...

Figure 1. A two-year-old boy came to medical attention because he lost consciousness four times over a period of five months. Three of the episodes occurred when the child became upset. These episodes had previously been diagnosed as “breath-holding ...

A peptidergic activity produced in endothelial cells that caused coronary vasoconstriction was described in 1985,¹ and a family of peptides, named the endothelins, was subsequently isolated and identified.² The three members of the family — endothelin-1, ...

In the decade since its initial description in the Journal, ¹ Escherichia coli O157:H7 has emerged as a major cause of both sporadic cases and outbreaks of diarrhea in North America. The first report described outbreaks of gastrointestinal illness that ...

Presentation of Case

A 46-year-old woman was admitted to the hospital for consideration of lung transplantation because of severe pulmonary hypertension.

The patient had been well and working as a secretary until 16 months earlier, when proximal-muscle ...

Kidney transplantation has become a routine and efficient treatment for end-stage renal disease.¹ However, a severe shortage of cadaveric kidneys has hampered wider use of this technique and is perhaps the most important obstacle facing transplantation ...

Since the dramatic unexpected death of the Greek soldier Pheidippides on completing his legendary run from Marathon to Athens in 490 b.c. to deliver the message of victory over the Persians, the problem of sudden death in athletes has intrigued the ...

Obesity affects up to one third of the population in many industrialized countries and increases the risk of several metabolic and cardiovascular disorders. The common belief that obesity results simply from overeating or from a sedentary lifestyle has ...

Sudden death, a devastating event for any family, strikes more than 300,000 Americans each year. Cardiac arrhythmias, particularly ventricular arrhythmias, are thought to account for about 11 percent of all sudden deaths. In some cases there appears to be ...

To the Editor: Regarding the article by Rawlings et al. (Jan. 12 issue),¹ we wonder whether a short interpregnancy interval might be confounded by factors that were not considered in the analysis. Although all the women studied were drawn from military ...

To the Editor: Regarding the article by Ville et al. entitled “Preliminary Experience with Endoscopic Laser Surgery for Severe Twin–Twin Transfusion Syndrome” (Jan. 26 issue),¹ the patients in that study had therapeutic amniocentesis performed at the ...

To the Editor: On the basis of a two-year follow-up, Thompson et al. (March 9 issue)¹ conducted a prospective study to evaluate the influence of hemostatic factors on cardiovascular risk. The authors report that patients with high cholesterol levels but ...

To the Editor: Puleo et al. (Sept. 1 issue)¹ described the use of a rapid test of subforms of creatine kinase MB (CK-MB) to diagnose myocardial infarction earlier than was previously thought to be possible. This report is of obvious importance, since the ...

To the Editor: With respect to the study by Bellinger et al. (March 2 issue),¹ in the large majority of newborns with transposition of the great arteries, in the absence of aortic-arch obstruction the arterial-switch operation can be performed with ...

To the Editor: There are two distinct areas of radiation oncology — external-beam radiotherapy and brachytherapy. The paper by Lichter and Lawrence (Feb. 9 issue)¹ mainly summarizes the advances in external-beam radiotherapy, without noting the advances ...

To the Editor: I had multiple large and painful fibromatoses of the flexor tendon sheaths of the fourth and fifth digits bilaterally for at least 10 years and was unable to extend the right fifth digit to form a right angle with the palm for more than 4 ...

To the Editor: Vasospasm has recently been reconsidered as a possible cause of amaurosis fugax.¹–³ Vasospasm was suspected in patients with recurrent episodes of visual loss that could not be attributed to an embolic source, carotid stenosis, ...

Drs. Podrid and Kowey invited 168 contributors to write a book on the state of the art in the study of cardiac arrhythmias. Their intention was to produce a useful book for a whole range of physicians: electrophysiologists, cardiologists, internists, and ...

Cardiac Electrophysiology: From Cell to Bedside is a remarkable book that lives up to the promise of its title. It is an encyclopedic review of all areas of adult and pediatric cardiac electrophysiology. It has been five years since the first edition, and ...

This book is number 20 in a series of textbooks reviewing fundamental and clinical cardiology. The editors, who are physicians in Saudi Arabia, have extensive personal experience with valvular heart disease, which enables them to write with conviction ...

It is rare that a medical textbook combines a well-written, comprehensive review of basic science with a thorough clinical review. Such is the case with Thrombolytic Therapy for Peripheral Vascular Disease, a superb book edited by Anthony J. Comerota. The ...

Swales's book on hypertension does well in fulfilling his ambitious aim of creating “a comprehensive critical text covering the complete spectrum of knowledge from mechanisms to management.” Dr. Swales had an advisory board of 10 eminent researchers in ...

In preparation for reviewing this book, I spent more than a few moments considering how much has changed in the treatment of hypertension over a generation of medical practice. For example, in my nonscientific poll of current internal-medicine residents I ...

Changes in Energy Expenditure Resulting from Altered Body Weight Original Article, N Engl J Med 1995:332;621-628.. On page 623, in Table 2, the initial weight results and the results after 10 percent weight loss in the nonobese and the obese subjects were ...