Myocarditis is a precursor of dilated cardiomyopathy.¹–³ Aberrant cellular and humoral immune responses have been proposed as possible mechanisms in postviral myocarditis,⁴–⁷ and immunosuppressive therapy has appeared to improve the course of the disease.^...

Ingestion of vegetable protein in place of animal protein appears to be associated with a lower risk of coronary heart disease¹,²; this effect may reflect decreases in serum cholesterol concentrations.³ The cholesterol-lowering effects of soy protein as ...

Hematopoietic progenitor cells in the peripheral blood are used increasingly to restore the formation of blood after high-dose chemotherapy for solid tumors or hematologic cancers.¹ As compared with rescue by autologous bone marrow transplantation, ...

Fabry's disease is an X-linked recessive disease resulting from a deficiency of the lysosomal hydrolase α-galactosidase.¹–³ This enzymatic defect leads to the progressive accumulation of glycosphingolipids, predominantly globotriaosylceramide, throughout ...

Arenaviruses are a group of RNA viruses several of which have the potential to cause a deadly syndrome of hemorrhagic fever. In humans these viruses are usually transmitted by exposure to infected rodent excreta; occasional laboratory or nosocomial ...

Figure 1. An anteroposterior radiograph of the great toes of a 41-year-old man with psoriatic arthritis shows that the toe on the left is normal. On the right there is soft-tissue swelling that is not confined to the distribution of the joint. The ...

Heterosexual transmission is responsible for most infection with the human immunodeficiency virus (HIV). The increase in pediatric HIV infection has had a substantial impact on childhood mortality, both in industrialized countries, such as the United ...

In the dozen years since the genetics of human cancer was first reviewed in these pages, we have achieved an understanding of the processes governing cell growth and differentiation that is quite sophisticated, but we still have far to go. For each ...

Stage

A 41-year-old woman collapsed at home and was taken to the hospital. In the emergency room, her blood pressure was 130/78 mm Hg, and her temperature was 36.5°C. No arrhythmia, murmur, or bruits were detected on cardiovascular examination. She was ...

The diagnosis of acute myocarditis has been a conundrum. One criterion is the clinical picture of the sudden onset of cardiac failure and arrhythmias, often associated with a febrile illness; the other criterion is a myocardial-biopsy specimen that shows ...

Since the beginning of the century, evidence of the cholesterol-lowering properties of dietary proteins of plant origin has been accumulating.¹ These effects, particularly of soy proteins, have repeatedly been observed in carefully controlled animal ...

During the development of the human embryo, hematopoietic cells first appear in the yolk sac, then migrate to the liver and from there to the bone marrow through the bloodstream. Until the 1970s, it was assumed that these cells resided exclusively in the ...

In August 1994, the public was inundated with media coverage of a laboratory accident at the Yale Arbovirus Research Unit that resulted in the hospitalization of a physician-virologist who had become infected with Sabiá virus, an obscure arenavirus from ...

To the Editor: Bryson and colleagues report the spontaneous clearance of human immunodeficiency virus (HIV) infection in a baby (March 30 issue).¹ Unfortunately, spontaneous clearance seems to be rare, and we have not observed it in any of 180 babies ...

To the Editor: Each of two important reports on Pneumocystis carinii in the March 23 issue¹,² lacks convincing proof of diagnosis.

The letter by Mortier et al.¹ describes maternal–fetal transmission of P. carinii associated with HIV infection. The case ...

To the Editor: We wish to address a statement made by Dr. Wong in his discussion of the differential diagnosis of panhypogammaglobulinemia in the Case Records (March 9 issue).¹ Dr. Wong states that “adults with HIV [human immunodeficiency virus]-...

To the Editor: Münke et al. describe a patient in whom hepatitis C developed after she had received a transfusion of coagulation factors (Feb. 9 issue).¹

According to the authors, five years after the transfusion, oral and genital ulcerations, pustules ...

To the Editor: We fully agree with the statement of Ganz and Friedman in their review article “Supraventricular Tachycardia” (Jan. 19 issue)¹ regarding the efficacy of adenosine in the termination of supraventricular tachycardia. However, to counter ...

To the Editor: Anderson et al. (Feb. 23 issue)¹ suggest that the patients in their study obtained the most improvement in endothelium-dependent coronary vasomotion when treated with cholesterol-lowering therapy in combination with an antioxidant. The ...

To the Editor: The article “Association between Plasma Homocysteine Concentrations and Extracranial Carotid-Artery Stenosis”¹ and the accompanying editorial “Can Lowering Homocysteine Levels Reduce Cardiovascular Risk?”² (Feb. 2 issue) draw attention to ...

To the Editor: The mechanism of the analgesia resulting from transcutaneous electrical nerve stimulation (TENS) is not clear. A possible mediator of TENS analgesia is adenosine, formed from adenosine triphosphate released from the large primary afferent ...

To the Editor: A 47-year-old beginning French-horn player experienced dizziness when he played notes higher than G. He was otherwise in good health except for essential hypertension, which was being treated with enalapril (2.5 mg twice a day). We ...

During the past decade, members of the infectious-disease and public health communities began to express concern about the appearance of new infectious diseases and the resurgence of previously recognized ones. The advent of the acquired immunodeficiency ...

Few areas of medicine remain untouched and unchanged by the AIDS pandemic. Ophthalmology is no exception. Ophthalmic manifestations were described in the first reports of patients with the disease, and nearly three quarters of all patients infected with ...

It can be argued that the historical accident whereby medicine and dentistry became separate realms has been detrimental to patient care. This is particularly true for patients with conditions that straddle the line between the two realms (i.e., systemic ...

This book lives up to its title. I found it to be a practical guide to the diagnosis, clinical features, treatment, and prevention of viral hepatitis A, B, C, D, and E. Although primarily intended to be a reference book for primary care physicians, ...

It is almost impossible to get through a day without thinking about medication. Patients sometimes speak of drugs that have produced less-than-optimal results in their care as “something that didn't do me any good.” Many others, however, tell me that a ...

Molecular Diagnosis Molecular Medicine, N Engl J Med 1995:332;1499-1502.. The sentence that begins in line 8 of the first paragraph of the article should have read, “Benign changes may occur in regions that do not encode protein or do not alter the ...