Ischemic stroke affects over 400,000 people in the United States annually,¹ and there is no direct treatment to reduce the extent of neurologic injury. Cerebral angiography conducted soon after the onset of stroke demonstrates arterial occlusions in 80 ...

Ischemic stroke accounts for approximately 85 percent of all strokes in Europe and North America and for 70 percent of those in the Far East.¹ Established methods of preventing such strokes in patients at high risk include treatment with antiplatelet ...

Neoplasia in early life has characteristics that suggest the importance of heritable factors in the causation of cancer.¹ Clinical and epidemiologic surveys²–¹⁰ have revealed that close relatives of children with cancer have an overall rate of cancer⁷–¹⁰ ...

Toxic epidermal necrolysis and Stevens–Johnson syndrome are acute life-threatening conditions. Epidermal necrosis causes erosions of the mucous membranes, extensive detachment of the epidermis, and severe constitutional symptoms.¹,² The physiopathologic ...

Figure 1. A right atrial mass was observed in a 42-year-old woman who presented with atrial fibrillation. A four-chamber view of the heart (Panel A) obtained intraoperatively by transesophageal echocardiography, demonstrated a mass in the right atrium (RA)...

Figure 1. A 40-year-old man was hospitalized after the development of toxic epidermal necrolysis on his chest (Panel A). The condition developed three weeks after the initiation of treatment with phenytoin and progressed caudally during a period of three ...

Primary tumors of the heart are rare, with an incidence between 0.0017 and 0.19 percent in unselected patients at autopsy.¹–⁵ Three quarters of the tumors are benign.¹,⁶–⁸ Nearly half the benign heart tumors are myxomas, and the majority of the rest are ...

Pneumonia has been recognized as a common and potentially lethal condition for nearly two centuries. Comprehensive studies of the disease in the pre-antibiotic era showed mortality rates of about 1 per 1000 per year; over 80 percent of the cases were due ...

Presentation of Case

A 68-year-old, right-handed man was admitted to the neurologic clinic because of paresthesias and severe pain in the hands.

The patient had been in stable health until 46 days earlier, when he had the sudden onset of increasingly ...

Ischemic stroke may occur with sudden cruelty and, when not fatal, may deplete the resources of the patient, family, and community. The most effective treatments are directed at the underlying causes of the initial ischemic event, the prevention of ...

In the past few years, studies in molecular genetics have improved our understanding of familial cancer and enriched our knowledge of carcinogenesis. In one kind of familial cancer, the same specific type of cancer occurs in excess, usually at a younger ...

In A Farewell to Arms, Hemingway said that childbirth was “a woman's battleground.” That statement is even more accurate today as women organize to make their voices heard in the offices of government and the boardrooms of insurance companies. How did the ...

To the Editor: The study by Lucas et al. (July 27 issue)¹ offered an opportunity to resolve a controversy in patient care that has divided neurologists and obstetricians for decades. However, their conclusion regarding the superiority of magnesium ...

To the Editor: It is important to clarify the role of amiodarone in patients with congestive heart failure, and the Survival Trial of Antiarrhythmic Therapy in Congestive Heart Failure reported by Singh and colleagues (July 13 issue)¹ advances the field. ...

To the Editor: Vichinsky and coworkers are to be applauded for their article (July 27 issue)¹ reporting that patients with sickle cell disease undergoing general anesthesia and surgery fare just as well with a less intensive transfusion regimen as with a ...

To the Editor: In their paper in the July 27 issue,¹ Giaid and Saleh demonstrate reduced expression of endothelial nitric oxide synthase in the lungs of patients with pulmonary hypertension. Although these data are extremely provocative, we have several ...

To the Editor: Gan et al. (July 13 issue)¹ report an association between a cystic fibrosis mutation that is common in the Netherlands (A455E) and mild pulmonary disease; this mutation has also been associated with relatively mild pancreatic involvement.² ...

To the Editor: The legend to the Image in Clinical Medicine by Ueda and Hall showing a giant colonic diverticulum (July 27 issue)¹ suggests that the patient's recurrent episodes of pain were causally related to the giant diverticulum of the sigmoid ...

To the Editor: Dr. Rubenfeld (July 27 issue)¹ portrays President Bill Clinton's recent physical examination² as “routine screening for a healthy 48-year-old man” and therefore inappropriate in its complexity. He believes that this bad example is likely ...

In the lore of the sea there are few events that have so exemplified heroism and self-sacrifice as the acts of the soldiers and sailors of the British ship Birkenhead when it sank in 1852. The soldiers of the 74th Highland Regiment stood at attention on ...

An early chapter of this book begins with a scenario that is played out every day in emergency rooms throughout the country:

A patient has arrived who had a sudden onset of aphasia and right hemiparesis three hours before. A CT scan of the brain is ...

This book is an excellent new contribution to the expanding field of neurobiology. Although a number of neuroscience textbooks are available, none have previously emphasized the relation between structure and function of the axon in detail. The editors of ...

This ambitious book covers a diverse set of topics ranging from the biochemical correlates of behavioral aberrations in Alzheimer's disease to psychosocial interventions and long-term care in end-stage dementia. Let me begin by acknowledging that my bias ...

Volavka's introduction to violence began at the age of 10 in a Nazi prison: “I would not recommend such experience to future researchers into violence, but it certainly focussed my mind on the problem.” Perhaps for that reason, he makes short work of Nazi ...

This encyclopedic overview of applications of nuclear medicine in a clinical setting is a substantial work containing 114 chapters by 149 authors from around the world. The book has eight major sections. The first seven describe the application of nuclear ...

Resistance to Penicillin and Cephalosporin and Mortality from Severe Pneumococcal Pneumonia in Barcelona, Spain Original Article, N Engl J Med 1995:333;474-480.. On page 477, some values in Table 4 were reversed. The corrected table appears below, with ...