Postmenopausal osteoporosis is a common disorder characterized by an increase in bone resorption relative to bone formation, generally in conjunction with an increased rate of bone turnover.¹ The progressive decrease in bone mass leads to an increased ...

In 1990, we requested information on each woman randomly assigned to treatment in any trial that began before 1985 and compared treatments for early breast cancer (i.e., breast cancer in which all clinically apparent disease can be removed surgically). ...

Findings from a clinical trial (Protocol B-06) conducted by the National Surgical Adjuvant Breast and Bowel Project (NSABP) to evaluate lumpectomy in the treatment of breast cancer have been reported previously in the Journal. ¹,² Life-table estimates ...

Chronic essential hypertension is a major risk factor for cardiovascular disease.¹–³ Morbidity and mortality from cardiovascular causes increase curvilinearly as blood pressure rises, with no evidence of a threshold of risk.⁴

Antihypertensive therapy has ...

Figure 1. Panel A shows the skeleton of a person buried at Unterhautzental, Austria, in the early Bronze Age (between 2200 and 1600 B.C.), and Panel B the results of dual-energy x-ray absorptiometry of the hip. It was determined that the person was a ...

The National Surgical Adjuvant Breast and Bowel Project (NSABP) Protocol B-06, a federally sponsored clinical trial that compared segmental mastectomy (lumpectomy) plus axillary dissection, with or without irradiation of the breast, with total mastectomy ...

A variety of skin diseases, autoimmune and inherited, are characterized by the presence of blisters. In some, such as pemphigus vulgaris, blistering is the primary manifestation. In others, such as lichen planus, blisters are infrequent. Most of these ...

Presentation of Case

A six-year-old boy was admitted in early August because of a rash, meningismus, and diplegia.

The boy had been well until three days earlier, when fatigue developed and he was chilled more easily than usual while swimming. The next ...

Osteoporosis is an increasing public health problem, and the costs related to hip fractures alone are expected to double in North America and Europe in the next 25 years. The disorder is characterized by enhanced bone fragility, resulting in an increased ...

Three articles in this issue of the Journal advance our understanding of the treatment of early breast cancer. In one, the advance comes in the form of reassurance about the quality of a study whose results have already been reported. The results of a ...

The ongoing shortage of human organs and tissues for transplantation, coupled with scientific and biotechnological advances, has catalyzed new attempts to use animal tissues in humans — a field known as xenotransplantation. Pigs and nonhuman primates have ...

To the Editor: The study by Lang and colleagues (July 20 issue)¹ is provocative but lacks two important control observations. First, as compared with the white subjects, the black subjects had markedly attenuated forearm blood-flow responses to ...

To the Editor: The European Atrial Fibrillation Trial demonstrated the efficacy of anticoagulant therapy in preventing stroke in high-risk patients with atrial fibrillation.¹ The results were convincing because the number of events among untreated ...

To the Editor: On the basis of a retrospective analysis of patients with mechanical heart valves who received high-intensity anticoagulation, Cannegieter et al. (July 6 issue)¹ conclude that the target international normalized ratio (INR) in such ...

To the Editor: Digitalis glycosides and macrolide antibiotics are both commonly prescribed medications. Erythromycin prolongs the clearance of digoxin by altering the flora in the distal portion of the intestine that metabolizes digoxin to various ...

To the Editor: Bennett et al.¹ report on thorough investigations into postoperative infections associated with the use of the intravenous anesthetic propofol, but we would like to add some comments.

Clusters of fever episodes, infections, or sepsis ...

To the Editor: Prioleau and Schnitt (June 1 issue)¹ reported a potential problem of p53 antigen loss in slides that had been stored at room temperature for two months. We examined slides that had been cut from formalin-fixed, paraffin-embedded blocks ...

To the Editor: Graudins et al. (July 20 issue)¹ report a case of an overdose of extended-release acetaminophen (Tylenol Extended Relief, McNeil Pharmaceuticals). We would like to provide additional information to help physicians evaluate such cases.

With ...

Philosophers, notoriously, are an ivory-towered lot. One philosopher who has never fit that mold is the Australian Peter Singer. Indeed, he has probably had a larger popular readership than any professional philosopher since Bertrand Russell, and more ...

In the glossary of this fine book, perinatology is defined as the branch of medicine dealing with the fetus and infant immediately before and after birth; its practitioners include obstetricians and neonatologists specializing in high-risk pregnancies and ...

This is the first book in the English language that presents a detailed analysis of the many aspects of pediatric care that are heavily influenced by social, political, environmental, and familial factors. The book links public health concerns with ...

Long-term care is a part of medical practice that affects enormous numbers of people and consumes a rising percentage of the health care budget, but to which comparatively little academic effort is devoted. Defined as the medical care, social services, ...

The late Allen Barbour, former head of the Division of General Internal Medicine and chief of the Stanford Diagnostic Clinic, was legendary among students, residents, and colleagues for his advocacy of person-centered care. He states, “By person-centered ...

Chronic Lymphocytic Leukemia Review Article, N Engl J Med 1995:333;1052-1057.. On page 1052, the sentence beginning in line 20 of the left-hand column should have read, “The proto-oncogenes lck and c-fgr,” not “lcr and c-fgr,” as printed. Also, in Table 2 ...