The cause of growth failure in the majority of short children who do not have a deficiency of growth hormone (GH) is unknown. These otherwise normal children with idiopathic short stature secrete normal amounts of GH in response to pharmacologic ...

Worldwide, chronic infection with the hepatitis B virus (HBV) is a major cause of morbidity and mortality from liver disease, cirrhosis, and hepatocellular carcinoma.¹ In the United States, approximately 1 million people have chronic hepatitis B, the ...

Reflux esophagitis is often a chronic disease. There is a high rate of relapse within one year after therapy is discontinued.¹–⁹ Results with maintenance therapy have often been disappointing. We compared three single-drug maintenance treatments (...

The development of coronary artery disease after cardiac transplantation is a leading cause of graft failure in recipients who survive the first year after operation.¹,² This transplantation-associated arteriopathy is characterized by rapid development,³,^...

Figure 1. A 49-year-old man underwent liver transplantation in 1989 for alcoholic cirrhosis. In 1994, ischemic cholangitis developed with strictures and signs of ascending cholangitis, leading to a second transplantation. Three weeks later, blood cultures ...

Drug-induced liver injury is a potential complication of nearly every medication that is prescribed, because the liver is central to the metabolic disposition of virtually all drugs and foreign substances.¹–³ Although drugs are usually metabolized without ...

Workplace exposures to hazardous materials cause or aggravate diseases as common and diverse as asthma, cancer, dermatitis, and tuberculosis.¹ Crude estimates of the number of new cases of occupational disease in the United States range from 125,000 to ...

Presentation of Case

A 43-year-old right-handed paraplegic man was admitted to the hospital because of increasing confusion and aphasia, increasing fatigue, weight loss, and new decubitus ulcers.

The patient had been well until four years earlier, when ...

The development of recombinant-DNA–derived human growth hormone (GH) has made it much easier to treat patients with GH deficiency.¹ Unfortunately, establishing a firm diagnosis of this deficiency is frequently difficult, even if detailed records of growth ...

Hepatitis B virus (HBV) infection has a major impact on the public health because of its frequency, morbidity, and late consequences. In the United States about 200,000 primary HBV infections occur annually. Between 5 and 10 percent of patients with ...

In gastroesophageal reflux disease, a failure of the barrier function between the stomach and the esophagus allows an excessive reflux of gastric or duodenogastric contents. Reflux disease is often chronic and tends to relapse. Although the disease often ...

To the Editor: The review of otitis media by Berman (June 8 issue)¹ makes clear that the number of cases of mastoiditis has decreased drastically in the past 40 years. Those who treated acute otitis media with antibiotics may regard antibiotics as the ...

To the Editor: The multicenter clinical trial of fluoxetine for the treatment of premenstrual mood symptoms reported by Steiner et al. (June 8 issue)¹ is good science but bad medicine. Cyclic changes in breast tenderness, fluid retention, nutrition, and ...

To the Editor: The article on transesophageal echocardiography (TEE) (May 11 issue)¹ by Daniel and Mügge is very informative. The authors point out that TEE is an invasive procedure and in most instances — all, in my experience — requires the use of ...

To the Editor: We do not fully agree with Dr. Service (April 27 issue)¹ on the evaluation of patients with hypoglycemia. In our hospital-based endocrinology group, we see 40 to 50 patients a year who are referred with this diagnosis. Many of them have ...

To the Editor: We congratulate Dr. Hunter (June 22 issue)¹ on her timely review. It must be emphasized, however, that neuromuscular blocking drugs should be used only by practitioners who are skilled in airway management and respiratory support, and only ...

To the Editor: Dombret et al. (June 22 issue)¹ report a striking difference in the rates of complete response between patients treated with granulocyte colony-stimulating factor (G-CSF) after chemotherapy for acute myeloid leukemia (AML) and patients not ...

To the Editor: Myenteric nerves innervating the internal sphincter muscle of the anus produce and release nitric oxide,¹,² the chemical messenger that mediates relaxation of this muscle.¹ A derangement in nitric oxide regulation may underlie the anal-...

To the Editor: Your editorial in the June 1 issue of the Journal ¹ gives an in-depth discussion of differential diagnosis and how it is being taught. I would like to comment on the concept of probability. Corporate executives use probability to make ...

Songwriters and performers who are fortunate enough to have a song played on the radio have instant access to millions of listeners who may buy an entire new compact disk because of a single song. Authors do not have the luxury of enticing us with a ...

This book has appeared at a propitious time. Last year the American Board of Psychiatry and Neurology began offering a subcertification in the field of addiction, and the Psychiatry Residency Review Committee recently mandated training in alcoholism and ...

Although there is agreement that disorganized eating behavior and abnormal body weight are crucial issues in general medicine and psychiatry, there is a frustrating lack of agreement about how to measure these types of behavior, the consequences, and ...

Childhood and Adolescent Diabetes will be a welcome addition to the home and office libraries of pediatric specialists and generalists. It comprehensively covers practical aspects of diabetes in childhood and adolescence, provides scholarly accounts of ...

This book begins with a discussion of sudden death and an overview that defines what is meant by “sudden.” There is some variability of definition in the literature, but for this review the victims have either been well or have had an apparently minor ...

A Clinical Trial of Active Management of Labor Original Article, N Engl J Med 1995:333;745-750.. On page 748, in Table 4, the third main entry in the left-most column of the table should have read, “Augmentation of labor with oxytocin (%),” not “Induction ...