Recently, increasing attention has been directed to the hemodynamic treatment of critically ill patients, because it has been observed in several studies that patients who survived had values for the cardiac index and oxygen delivery that were higher than ...

Since the classic work of Dicke in 1950 it has been known that wheat and rye damage the small-intestinal mucosa of patients with celiac disease.¹ The injurious constituent is α-gliadin.²–⁴ Although wheat, rye, and barley are harmful to the small-...

Reactivation of latent cytomegalovirus (CMV) infection in immunocompromised patients causes considerable morbidity and mortality.¹–⁶ CMV is excreted in the urine after allogeneic bone marrow transplantation by approximately 70 percent of CMV-seropositive ...

Vaccines consisting of inactivated Bordetella pertussis induce protection against pertussis, but estimates of their efficacy vary from 40 to 90 percent.¹ There is no consensus about what the protective moieties are in whole-cell vaccines or what mechanism ...

Figure 1. A mitochondrion of a murine peritoneal macrophage is shown after exposure to peptidoglycan (×20,000).

Chronic lymphocytic leukemia (CLL), the most frequent form of leukemia in Western countries, is characterized by the clonal proliferation and accumulation of neoplastic B lymphocytes in the blood, bone marrow, lymph nodes, and spleen. The median age of ...

Alcohol is the most frequently abused drug throughout the world. In the United States, it is consumed regularly by about half the adult population, and about 15 to 20 million people are alcoholics. Alcoholism claims 100,000 lives annually and carries an ...

Presentation of Case

A 78-year-old woman was admitted to the hospital because of worsening dysphagia and odynophagia.

For three years, she had had dysphagia, with a sensation of solid food catching in the upper esophagus, which had worsened during the six ...

Survival after trauma, surgery, or sepsis is associated with the attainment of high levels of oxygen delivery and oxygen consumption.¹ This observation has fueled the expectation that the outcome of critical illness may be improved by attempts to ...

Celiac disease, a gluten-sensitive enteropathy, is treated with a gluten-free diet. Whether to include oats in the diet for patients with celiac disease has been debated at length for the past 30 years. It is therefore surprising that so few studies have ...

To the Editor: The editorial “The Internet and the Journal” (June 22 issue)¹ addresses the pros and cons of electronic “publishing” of articles on the Internet. You mentioned abstracts in passing, but the specter of electronic publishing of abstracts ...

To the Editor: In the Clinical Problem-Solving case presented by Dr. Duffy (June 1 issue),¹ concerning a patient with hemolytic anemia due to cold agglutinins who later received a diagnosis of large-cell lymphoma, there was a failure to probe for an ...

To the Editor: The article by Fuchs et al. (May 11 issue)¹ on the relation between alcohol consumption and mortality among women should set women's minds at ease, especially women at risk for coronary heart disease who drink. It appears that such women ...

To the Editor: In their article on the discontinuation of antihyperlipidemic drugs, Andrade et al. (April 27 issue)¹ discuss the generalizability of the results of randomized trials. Specifically, they state that discontinuation rates in randomized ...

To the Editor: Unlike dermatomyositis in adults, dermatomyositis in children is rarely associated with cancer. We describe a case of juvenile dermatomyositis associated with hepatocarcinoma.

A 14-year-old boy with a weight loss of 15 kg over a three-...

To the Editor: Of the more than 40 million patients hospitalized in the United States yearly, approximately 2 million acquire nosocomial infections.¹ Patients with infections frequently remain in the hospital to complete courses of antibiotic therapy ...

To the Editor: While cleaning out my desk, I found the enclosed bill for my one-day stay at the Children's Hospital for a tonsillectomy when I was 11 years old (Figure 1). Several things struck me about it, especially in comparison with a hospital bill ...

In April 1994, my confidence and sense of security in my professional status and competence were shaken to the core. In that month, for reasons too complex to elaborate, I lost my new job a mere 10 working days after my arrival in Norfolk, Virginia. Two ...

In the dynamic world of cellular neuroscience today, dominated as it is by single-channel kinetics and molecular neurobiology, the very word “histology” seems dry and static. Yet this new translation of the classic work by Santiago Ramón y Cajal is a ...

Idiopathic. Denoting a disease of unknown cause.

— Stedman's Medical Dictionary

Idiopathic. . . . of a disease; of the nature of a primary morbid state; not consequent upon another disease.

— Oxford Universal Dictionary

Few aspects of modern ...

The field of developmental neuropsychology has grown substantially since the original 1984 version of this book. The authors have done an excellent job of revising and updating an enormous amount of clinical material that should be of great interest to ...

Hearing loss is perhaps the most prevalent of all the chronic diseases, with over 20 million Americans suffering from hearing impairment severe enough to affect their ability to communicate. The profound deafness that affects roughly 1 in 1000 newborns ...

Chronic Urticaria Review Article, N Engl J Med 1995:332;1767-1772.. On page 1768, in the right-hand column, the sentence that begins in line 18 should have read, "The identification is confirmed by the ability of the serum samples to cause the release of ...