O'Driscoll and colleagues at the National Maternity Hospital in Dublin, Ireland, pioneered a multifaceted approach to the management of labor in nulliparous women that is now referred to as active management of labor.¹ It was introduced to shorten labor ...

In the United States, human immunodeficiency virus (HIV) disease is now a leading cause of death in adults 25 to 44 years old.¹ A large population of patients with HIV infection in the United States are members of racial or ethnic minorities, and a ...

Platelet aggregation, the generation of thrombin, and the release of growth factors at the site of angioplasty have all been implicated in the process of restenosis.¹,² Consequently, anticoagulants, antiplatelet agents, and specific antithrombin agents ...

Heparin is often given to patients during coronary angioplasty to inhibit coagulation locally within a segment of the coronary artery and thus prevent closure of the dilated vessel. High doses of heparin are commonly used during coronary angioplasty to ...

Subclinical shedding of herpes simplex virus (HSV) occurs in persons with a history of genital herpes and is instrumental in transmitting HSV infection to sexual partners and neonates.¹–⁷ The rate of subclinical shedding among persons with recurrent ...

Figure 1. A 31-year-old woman who had had painless, right-sided cervical adenopathy for three months was given antibiotics, but the adenopathy persisted. She had no systemic symptoms and no other palpable lymph nodes, and the remainder of her physical ...

Many patients with severe mental illness are addicted to drugs and alcohol, creating additional problems for the patients and for the clinicians, health care systems, and social-service agencies that provide services to this population. Drug abuse often ...

Two and a half years ago, when I was still a private citizen working at the University of California, San Francisco, my colleagues, Mike Bishop and Marc Kirschner, and I offered advice to our new President in Science magazine.¹ The first of our 11 ...

Presentation of Case

A 65-year-old man was admitted to the hospital because of Hodgkin's disease of the anterior mediastinum and the radiographic finding of a pelvic mass.

The patient had been well until about four months earlier, when pleuritic pain ...

One of the agencies singled out for elimination in the recent spate of Congressional budget cutting was the National Center for Injury Prevention and Control (NCIPC), a part of the Centers for Disease Control and Prevention (CDC).¹ Given the wide swath of ...

Schizophrenia and addiction are two disorders that are difficult to treat, but when combined — resulting in a compound condition, or “dual diagnosis” — each disorder usually complicates the other. Drugs and alcohol may exacerbate hallucinations and ...

To the Editor: An apparently new human herpesvirus, designated Kaposi's sarcoma–associated herpesvirus (KSHV) or human herpesvirus 8, has recently been identified in samples of Kaposi's sarcoma from patients infected with the human immunodeficiency virus ...

To the Editor: As Dr. Zidar notes in the legend accompanying the image of periorbital edema associated with AIDS-related Kaposi's sarcoma (May 4 issue),¹ edema is a common problem in patients with AIDS-associated Kaposi's sarcoma, especially those with ...

To the Editor: Rapid identification of the genotype of an isolate of hepatitis C virus (HCV) obtained from an organ donor may offer a means of preventing infection by new, genetically different viruses in recipients who are already HCV-positive.¹ Current ...

To the Editor: Fraser et al. (April 27 issue)¹ contend that the higher risk for low birth weight and premature birth associated with young maternal age may reflect an underlying inherent biologic risk. However, the contribution of environmental factors, ...

To the Editor: In their excellent review of the complications of diabetes mellitus (May 4 issue),¹ Drs. Clark and Lee recommend amitriptyline as the tricyclic drug of choice for the treatment of symptomatic peripheral neuropathy, stating that this agent ...

To the Editor: Although the study of Cortelazzo and colleagues (April 27 issue)¹ was not designed to assess the role of antiplatelet drugs in preventing vascular thrombotic complications of essential thrombocythemia, the authors note that the relative ...

To the Editor: While examining imported traditional Chinese medicines for the presence of products from endangered species, we have detected potentially toxic levels of arsenic and mercury in certain herbal-ball preparations.

Herbal balls are aromatic, ...

The use of cardiopulmonary resuscitation (CPR) must be considered carefully, especially in the case of terminally ill and elderly patients.¹–³ In Japan, most physicians (96 percent) are aware of do-not-resuscitate (DNR) orders,⁴ but unlike the situation ...

Every week it seems that a new cancer gene is discovered, and every month, a suspected carcinogen. Who will summarize this avalanche of information and integrate it for wide use?

With Familial and Hereditary Tumors, Dr. Ponz de Leon, professor of internal ...

Basil A. Stoll has assembled a timely book about a subject of intense interest to both health care providers and women. It contains 27 chapters written by top experts in various aspects of breast-cancer risk. I was quite pleased to have this book come ...

At 2350 pages, this book is in every sense substantial. It attempts to address the interests and needs of students, general physicians, and cancer specialists in all disciplines. Meeting this goal is a formidable challenge, since it requires the ...

The incidence of pulmonary neoplasms has increased substantially since the turn of the century, and lung cancer now accounts for the highest percentage of deaths from cancer in this country. Pulmonary tumors are thus likely to be encountered by primary ...

Prevention and Treatment of the Complications of Diabetes Mellitus Review Article, N Engl J Med 1995:332;1210-1217.. On page 1214, the sentence beginning in line 35 of the left-hand column should have read, “Their specificities are fairly low (87 percent ...