Substantial evidence suggests that the regular use of aspirin and other nonsteroidal antiinflammatory agents (NSAIDs) reduces the risk of colorectal cancer. Case–control studies have consistently found an inverse association between the use of aspirin and ...

Cytomegalovirus retinitis is an infection associated with the acquired immunodeficiency syndrome (AIDS) that, if left untreated, causes progressive retinal destruction with partial or complete visual loss. Retinitis develops in up to 40 percent of ...

Hypercholesterolemia is common after cardiac transplantation, affecting 60 to 80 percent of transplant recipients.¹ In addition, hypercholesterolemia has been associated with the development of coronary vasculopathy in transplants,²–⁴ which is the major ...

The interaction of ketoconazole with cyclosporine, resulting in the delayed metabolism of cyclosporine, and the potential for cyclosporine-induced nephrotoxic effects have been well described.¹,² The key to the safe administration of these two agents in ...

The Zollinger–Ellison syndrome manifests itself in 90 to 95 percent of cases as severe peptic ulcer disease.¹ About half the time, the ulcer disease is associated with diarrhea, and in approximately 10 percent of patients, diarrhea is the only clinical ...

Figure 1. A 35-year-old man with the acquired immunodeficiency syndrome presented with floaters and blurred vision in both eyes. In the left eye (Panel A), the white wedge-shaped areas with accompanying hemorrhage along the inferior vascular arcade (...

The mitochondrial encephalomyopathies are a diverse group of disorders that result from the structural, biochemical, or genetic derangement of mitochondria.¹ Since mitochondrial dysfunction can affect virtually all organ systems (Figure 1), physicians in ...

Hardly a month goes by without a report that some new gene for a human disease has been cloned. Recently, for example, the genes responsible for ataxia–telangiectasia and early-onset Alzheimer's disease were isolated. In the final analysis, such studies ...

Stage

A 25-year-old Hispanic woman in the 27th week of pregnancy came to the emergency room complaining of cough and shortness of breath. She reported that she had been well until two days earlier. In the past day she had also been nauseated, and she had ...

It's open season on the policies and opinions of journal editors, which provide an exciting new target for writers, commentators, and even fellow editors.¹–⁷ Now well into my fifth year as editor-in-chief of the oldest, largest (in paid subscriptions), ...

The article by Giovannucci et al. in this issue of the Journal ¹ promises an important advance in cancer prevention. An analysis of the incidence of colorectal cancer among women participating in the Nurses' Health Study according to whether they did or ...

Cytomegalovirus retinitis is a devastating complication that may occur in as many as 40 percent of patients with the acquired immunodeficiency syndrome (AIDS).¹ Lifelong daily intravenous infusions of ganciclovir or foscarnet can usually control ...

The first decade of orthotopic heart transplantation featured the perfection of the surgical techniques, the use of immunosuppressive drugs, and the introduction of endomyocardial biopsy. Improved survival rates of 85 percent and 70 percent after one and ...

Ataxia–telangiectasia is a rare autosomal recessive disorder with diverse clinical manifestations. Patients typically come to medical attention in early childhood because of ataxia, and this is followed by progressive neuromotor degeneration, usually ...

To the Editor: Inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, widely prescribed to treat hypercholesterolemia, are clearly effective and are associated with reductions in mortality from coronary disease and overall mortality.¹ ...

To the Editor: The finding by Khamashta et al. (April 13 issue)¹ supports those of two recent studies,²,³ which demonstrated that patients with antiphospholipid antibodies are in an ongoing prothrombotic state. In this condition there are high plasma ...

To the Editor: As a recent legal immigrant to this country, I agree with Iseman and Starke (April 20 issue)¹ that “refining immigration procedures” is the better of the two alternatives they propose. However, I disagree with their suggestion that ...

To the Editor: Oral estrogen treatment is associated with weight gain and often with the perception on the patient's part of increased adiposity.¹ Evidence of increased body fat is lacking, and the possible mechanism involved is not known. We report the ...

To the Editor: Cytomegalovirus retinitis is among the most common infections in patients with AIDS. With survival increasing in patients with AIDS as a result of successful primary prophylaxis against Pneumocystis carinii pneumonia, cytomegalovirus ...

To the Editor: Evidence of the therapeutic value and limited toxicity of marijuana in the treatment of various symptoms and syndromes is rapidly accumulating. Patients with glaucoma, migraine, epilepsy, multiple sclerosis, paraplegia, quadriplegia, the ...

Anyone bold enough to predict 50 years ago that by the coming turn of the century a substantial proportion of hematologic diseases, and some nonhematologic diseases, would be treated successfully by clinicians collecting marrow cells from one person and ...

The study of multiple myeloma has fascinated and challenged a multitude of workers in basic science and clinical medicine. Nevertheless, progress in treating this disease has been slow. The cause is unknown, and because the ancestral myeloma cell is ...

The field of cancer prevention and control includes a broad range of related ideas, methods, and activities; its practitioners, researchers, and teachers come from many disciplines. Its scientific basis is being advanced by increasingly sophisticated ...

“Age is the major risk factor for the majority of cancers, half of which become clinically evident in people over 70 years old.” So ends the first paragraph of the preface to this book addressing problems of cancer in old age. With continuing declines in ...

The field of tumor markers is fast-moving and littered with hopefuls and might-have-beens. Only a handful of markers have passed successfully from study in the basic laboratory to common clinical use. Earlier studies dealt predominantly with protein ...

Therapy of Unresectable Hepatocellular Carcinoma Editorial, N Engl J Med 1995:332;1294-1296.. On page 1295, in the left-hand column, the sentence that begins on line 3 should have read, “The rate of complete tumor necrosis obtained by percutaneous ethanol ...

Book Review of Development through Life: A Handbook for Clinicians Book Review, N Engl J Med 1995:333;1796-1797.. The name and affiliation of the author of the review were given incorrectly. They should have read, “Wladimir Wertelecki, M.D., University of ...