Cholesterol-lowering therapy has been associated with a decreased risk of ischemic coronary events and with angiographically detectable regression of atherosclerosis.¹–⁵ However, regression of atherosclerosis as assessed by angiography has been slight as ...

Hypercholesterolemia is a health risk, and epidemiologic studies have shown a link between total cholesterol levels and the risk of cardiac events.¹,² Studies have shown that lowering the levels of total and low-density lipoprotein (LDL) cholesterol can ...

Cystic fibrosis is the commonest recessive genetic disease of whites. About 2 to 4 percent of all white persons carry the gene for cystic fibrosis, and there are approximately 25,000 patients with this disease in the United States.¹ The disease has a ...

Between 1970 and 1984, Romania participated in a study of the safety of the live attenuated oral poliovirus vaccine (OPV) coordinated by the World Health Organization. Several reports from this study showed that the risk of vaccine-associated paralytic ...

We describe a patient with a unique mantle-cell lymphoma, with cycles of acute illness alternating with spontaneous remissions. During the acute phase the patient had fever, generalized lymphadenopathy, hepatosplenomegaly, increased liver-enzyme ...

Figure 1. Plain films of the knees of a 50-year-old woman receiving long-term corticosteroid therapy reveal medullary bone infarcts in the distal femurs and proximal tibias. Serpiginous lucencies with peripheral sclerotic rims represent necrotic spongy ...

The causal role of an elevated serum cholesterol level in the genesis of atherosclerosis and its clinical sequelae, particularly ischemic heart disease, is now well established. The recognition of this role has been the impetus for numerous trials ...

Presentation of Case

A one-month-old girl was admitted to the hospital because of an intraabdominal mass.

After a 42-week gestation, the infant had been delivered by cesarean section because of cephalopelvic disproportion. There were no complications ...

The global eradication of poliomyelitis has been targeted as a goal for the year 2000 by the World Health Organization,¹ and naturally occurring poliomyelitis has already been eradicated from the Americas.² Yet the occasional occurrence of paralytic ...

Each year thousands of reviewers contribute their expertise to peer review, a process that contributes critically to the quality of the Journal. The editors and the authors of the papers submitted to the Journal are grateful for the help of all our ...

On December 30, 1994, a man walked into two abortion clinics in Brookline, Massachusetts, and opened fire, killing two employees and wounding five others. Acts of violence have occurred in health care settings before. Medical providers, particularly ...

The use of direct DNA-based testing in forensic analysis has become increasingly common. In the past, genetic identity or similarity could be inferred by comparison of ABO blood groups and other protein-based measurements. These measures are sufficiently ...

To the Editor: The Benestent¹ and Stent Restenosis (STRESS)² studies (Aug. 25 issue) raise important questions about strategies for coronary-stent placement. Should coronary stents be considered for all patients with new focal lesions in large coronary ...

To the Editor: The case presented by Thibault (Nov. 3 issue)¹ illustrates a very common problem in clinical cardiopulmonary medicine. A simple objective test is widely available that would probably have averted the extensive and expensive workup.

The ...

To the Editor: Brittberg et al. (Oct. 6 issue)¹ are to be commended for conducting a study of 23 patients that not only involved the transfer of articular and nonarticular tissue into deep cartilage defects in the knee but also required two follow-up ...

To the Editor: The case report in the October 13 issue¹ describes a newborn boy with juvenile chronic myelogenous leukemia that was diagnosed on the basis of “an open-liver biopsy, which revealed an extensive . . . infiltrate composed of immature-...

To the Editor: The content of trans fatty acids in our foods has been causing concern¹ because of reported adverse effects on serum lipid levels² and coronary heart disease.³ Even a typical Western diet can have enough of these trans isomers to elevate ...

How is one to describe a book in which chapter 1 begins with the words “In the beginning . . .” and that then proceeds to discuss, in 32 chapters, the history of humanity and the development of medicine and medical ethics — up to, and including, the ill-...

At a time when there are 3 million reports of suspected abuse or neglect of children each year in the United States, when homicide is the leading cause of injury-related deaths among infants, when the Advisory Board on Child Abuse and Neglect has claimed ...

Justice and the Human Genome Project is a collection of essays based on presentations at a conference with the same title sponsored by the Department of Energy and the University of Illinois at Chicago in November 1991. The Ethical, Legal, and Social ...

In terms of the range of his interests and his degree of success, Carl Djerassi is a pioneering model of what has recently become more common: the gifted laboratory scientist with entrepreneurial and humanistic ambitions. If not the “father of the Pill” (...

Musculoskeletal symptoms are among the most common problems confronting the primary care physician. With the advent of managed care and capitation, pediatricians and generalists both will have to sift through more and more of these orthopedic puzzles. ...