Late-luteal-phase dysphoric disorder,¹ currently referred to as premenstrual dysphoric disorder² (and commonly called the premenstrual syndrome), is characterized by a cluster of symptoms appearing regularly during the week before and disappearing within ...

In 1992, Berkel and colleagues reported the results of a study examining the potential relation between breast implantation and the subsequent development of breast cancer.¹ After this work was published, a number of potential errors in the study methods ...

The permeability of the collecting ducts of the kidney to water increases rapidly in response to vasopressin. In what is called the shuttle hypothesis, this increase is believed to be mediated by the movement of a vasopressin-regulated water-channel ...

Fibrous dysplasia is a sporadic developmental condition that affects bone structure.¹ The disease is characterized histologically by the persistence of woven bone where lamellar bone would normally develop. Marrow fibrosis is intense, and the rate of bone ...

Figure 1. Linear microecchymoses, produced by rubbing the edge of a coin on the skin, are visible on a 33-year-old Vietnamese man who had been using this traditional Southeast Asian treatment unsuccessfully for recurrent migraine headaches. The ...

Platelets have a key role in atherosclerosis, thrombosis, and acute coronary syndromes. Therapeutic manipulation of platelet function has focused principally on the use of aspirin, which has proved effective in many clinical situations, despite its ...

The frequency of otitis media is one of a number of factors causing physicians to seek out the most cost-effective clinical strategies for managing the condition. It is estimated that, by the time they reach two years of age, all the children in the ...

Presentation of Case

An 81-year-old woman was admitted to the hospital because of severe pulmonary edema after aortic-valve and mitral-valve replacements.

The patient had been in good health until four years earlier, when severe dyspnea developed. A ...

In 1847, Dr. Ernst F. von Feuchtersleben wrote that “The menses in sensitive women is almost always attended by mental uneasiness, irritability, and sadness.”¹ Over the past 100 years, this identification of some form of “sensitivity” as a basis for the ...

The movement of water across the cell membranes of an organism is of central importance in many functions. The notion that the permeability of some tissues to water is too great to be accounted for by lipid-mediated diffusion has been central to the ...

Intracellular signal-transduction pathways have central roles in processes such as growth, development, cellular differentiation, and neurotransmission. Alterations in the levels of various substances involved in signal-transduction pathways have profound ...

To the Editor: On the basis of a prospective study, Fuchs and colleagues (Dec. 22 issue)¹ estimate that the relative risk of colorectal cancer is 5.37 for people younger than 45 years of age who have one or more affected first-degree relatives. In an ...

To the Editor: Mansfield et al. (Dec. 29 issue)¹ found that ultrasound-guided location of the subclavian vein was not beneficial, as compared with standard insertion procedures for subclavian-vein catheterization. The authors used ultrasound only to mark ...

To the Editor: Chui et al. (Dec. 22 issue)¹ found that hydrocolonic ultrasonography was less useful than colonoscopy for detecting colorectal polyps and cancers. Although their data may well be accurate, their conclusions contradict not only my ...

To the Editor: Pankratz and Jackson (Dec. 29 issue)¹ identified 35 men as habitually wandering patients (discharged from four or more Department of Veterans Affairs medical centers annually between 1988 and 1992), and observed that little is known about ...

To the Editor: Recombinant interferon beta-1b (Betaseron) was licensed in 1993 to reduce exacerbations of multiple sclerosis. Approval of the drug was greeted enthusiastically, despite a modest 30 percent reduction in relapses and side effects that ...

To the Editor: We report a case of subdural hematoma caused by riding on a roller coaster.

A 64-year-old man presented to our neurology clinic with a 10-week history of headache. He was healthy, apart from hypertension controlled by triamterene (Dyazide) ...

The Oxford Textbook of Surgery represents, in this information-rich era, a very noteworthy accomplishment. Edited by Ronald A. Malt of the Massachusetts General Hospital in Boston and Peter J. Morris of the Oxford University Clinical School, this massive ...

Surgical Infections is an attractive book. The quality of the paper, diagrams, and x-ray images adds to its readability. As I flipped through the table of contents to get a sense of the book's scope and organization, I was impressed by the encyclopedic ...

Thy publish another textbook of pediatric surgery when the field is already crowded with alternatives? A group of distinguished pediatric surgeons, who will also edit a forthcoming large, two-volume textbook on pediatric surgery, have produced this work ...

Few would dispute that the relatively young specialty of critical care medicine has come of age. In the bad old days, when all general surgeons and internists thought they knew how to “drive the ventilator” and prescribe fluids for a patient with septic ...

Dissection of the Ascending Thoracic Aorta Images in Clinical Medicine, N Engl J Med 1994:330;1361.. The title of the Image in Clinical Medicine should have been “Dissection of the Descending Thoracic Aorta,” and the legend should have read as follows:

A ...

The Transjugular Intrahepatic Portosystemic Stent–Shunt Procedure for Refractory Ascites Original Article, N Engl J Med 1995:332;1192-1197.. On page 1197, the journal cited in reference 34 should have been Radiology, not Interventional Radiology, as ...