Prostate cancer is the most commonly diagnosed malignant condition and the second leading cause of cancer-related death in American men.¹ In its early stage the disease is sometimes curable by radical prostatectomy or radiation therapy. However, ...

Malaria remains a major cause of childhood morbidity and mortality in the tropics. The World Health Organization (WHO) has worked to define standard criteria for the recognition and management of severe malarial disease.¹ However, although African ...

Retinoids, including vitamin A and its analogues, regulate the morphogenesis, development, and growth and differentiation of cells.¹–³ Retinoids can also halt the progression of disease in premalignant lesions of the oral cavity, cervix, and skin and can ...

Diethylstilbestrol is an orally active synthetic estrogen that for many years was thought to prevent complications of pregnancy. Between the late 1940s and the early 1970s, diethylstilbestrol was prescribed for 2 million to 3 million women in the United ...

Figure 1. Intraleukocytic inclusion bodies of ehrlichia species are visible in buffy-coat smears from a 13-year-old girl with fever, encephalitis, neutropenia, and disseminated intravascular coagulation (×1000). The arrows in Panel A and Panel B show the ...

The value of thrombolytic therapy for patients with acute myocardial infarction has been firmly established. To identify the thrombolytic approach that most effectively produces sustained patency of the infarct-related artery and improves survival, the ...

Child abuse, long neglected by both society and medicine, is now a focus of public attention. Cases of suspected maltreatment are often featured in the news media and argued in the courts. Some cases raise profound questions about the relative rights of ...

Presentation of Case

A 35-year-old man was admitted to the hospital because of recurrent ventricular tachycardia.

The patient had been well until seven months earlier, when ventricular tachycardia occurred and a diagnosis of dilated cardiomyopathy was ...

It has been known for almost a century that testosterone and its intracellular mediator, dihydrotestosterone, control the development and function of the prostate gland. Huggins and his colleagues used this knowledge to show that medical or surgical ...

It is rare, in these days of magnetic resonance imaging and gene sequencing, for investigators to make advances in our understanding of a common disease on the basis of bedside clinical observations alone, yet Kevin Marsh and his colleagues, working on ...

Not so long ago, therapies that led to a survival advantage in randomized trials were quickly endorsed and adopted. The costs required to achieve the clinical benefit were of only minimal interest to the primary decision makers — physicians seeking the ...

To the Editor: In their Sounding Board article on the use of newly deceased patients in teaching resuscitation (Dec. 15 issue),¹ Burns and colleagues conclude that permission must be obtained from the next of kin. This is in contrast to the position of ...

To the Editor: The review of deep-vein thrombosis by Weinmann and Salzman (Dec. 15 issue)¹ states that thromboembolic disease during pregnancy occurs primarily in the postpartum period. We disagree with this assertion. The risk of thromboembolic disease ...

To the Editor: The study by Geerts et al. (Dec. 15 issue)¹ emphasizes once again the substantial incidence of thromboembolism after major trauma. We were surprised, however, that such a prospective study was undertaken in a group of high-risk patients ...

To the Editor: We have become aware of two minor errors in the data we used in our article on contributions from the American Medical Political Action Committee (AMPAC) to members of Congress (Jan. 6, 1994, issue).¹ The first error occurred when we ...

To the Editor: Ultraviolet A radiation used for cosmetic tanning is thought to be capable of inducing nonmelanoma skin cancer.¹,² Premalignant keratoses, but not cancers, have been observed in users of tanning beds.³

A 43-year-old woman presented in ...

Children, and those who believe children have rights, are an unpopular bunch these days. Children who misbehave for any reason are even less well liked. A January 3, 1994, Wall Street Journal editorial warns us that a certain health care plan disguises ...

It is a measure of both the prudery and the prurience of our times that this book derives from a survey that evaded the S word and was named the National Health and Social Life Survey. Names are influential. They are shaped by one's assumptions and in ...

The development of sophisticated intensive care techniques for use in newborn infants has increased the survival of many critically ill and frequently very tiny neonates. Nevertheless, the incidence of developmental handicaps in those who survive has not ...

Perhaps for obvious reasons, the phrases “high adventure” and “pediatric neuropathology” do not often roll off the tongue together. Nevertheless, Pediatric Neuropathology is a highly adventurous book. Indeed, the subspecialty orientation the title ...

Preserved Endothelium-Dependent Vasodilatation in Patients with Essential Hypertension Original Article, N Engl J Med 1994:330;1036-1040.. On page 1037, in Table 1, the second-study values for “Cholesterol level” should have been listed as 232.0±38 for ...

Case Records of the Massachusetts General Hospital (Case 18-1994) Case Records of the Massachusetts General Hospital, N Engl J Med 1994:330;1300-1306.. On page 1301 the legend to Figure 2 should have read, “CT Scan of the Brain, Revealing Right ...