In the United States, mortality among black infants is currently twice that among white infants.¹ This disparity is strongly linked to the two-to-threefold greater prevalence of low birth weight and prematurity among black infants.² Mortality directly ...

Urinary symptoms compatible with the diagnosis of benign prostatic hyperplasia are extremely common in older men.¹ A small percentage of men with benign prostatic hyperplasia have intractable urinary retention or evidence of obstructive uropathy in the ...

The outcome of patients with acute myocardial infarction has been improved by the early administration of drugs such as thrombolytic agents, beta-blockers, and aspirin.¹–⁵ The use of angiotensin-converting–enzyme (ACE) inhibitors has also been reported to ...

The major histocompatibility complex (MHC) class II molecules are composed of two polypeptide chains (α and β). In humans the three distinct isotypes are designated HLA-DR, DP, and DQ. The different isotypes serve similar functions, and their expression ...

Figure 1. A 67-year-old man, adequately treated for tuberculosis 15 years previously, had a three-week history of hemoptysis that was not accompanied by fever, chills, malaise, night sweats, weight loss, or other systemic symptoms. He also had no chest ...

The risk of tuberculosis among health care workers was substantial in the era before antibiotics¹ but declined rapidly after 1950 because of the lower incidence of the disease in the population and the advent of effective therapy. These changes resulted ...

Benign prostatic hyperplasia is a nonmalignant enlargement of the prostate that is due to excessive cellular growth of both the glandular and the stromal elements of the gland. The condition is very common in men over 40 years of age of all races and ...

Presentation of Case

An 80-year-old man was admitted to the hospital because of an enlarging lung tumor of long duration, recurrent bouts of postobstructive pneumonia, and recent respiratory distress.

There was a history of a slowly growing mass in the ...

Black women in the United States remain at greater risk of bearing low-birth-weight infants (those weighing less than 2500 g) than white women. In 1991, 13.5 percent of black mothers gave birth to low-birth-weight infants, as compared with only 5.8 ...

Any new therapeutic advance requires clear proof of effectiveness from well-designed and well-conducted clinical trials that establish both the range of anticipated benefits and the potential adverse effects. However, for the results of clinical trials to ...

Elucidating the molecular and genetic basis of a hereditary disease often has implications that go beyond the understanding of the disease itself and that may concern important biologic processes. When it was shown that a form of primary immunodeficiency, ...

To the Editor: The Journal's policy on cost-effectiveness analyses (Sept. 8 issue)¹ does more to harm the field of cost-effectiveness research than it will do to improve its validity or quality.

The new policy is based on several erroneous assumptions. ...

To the Editor: With respect to the Clinical Problem-Solving article describing a young man requiring coronary angioplasty (Sept. 1 issue),¹ we wish to take issue with the discussant's statement that “it is difficult to find much fault with either the ...

To the Editor: In the study by Lichtiger et al. (June 30 issue),¹ we were surprised by the high frequency of neurologic side effects in the cyclosporine-treated patients. In a review of 3000 recipients of kidney transplants and 800 recipients of bone ...

To the Editor: Most patients treated with lithium have side effects, as Price and Heninger note in their review (Sept. 1 issue),¹ but the authors do not emphasize the potential severity of these effects. Lithium poisoning results from therapeutic doses ...

To the Editor: Parvovirus B19 causes erythema infectiosum,¹ transient aplastic crisis,² hydrops fetalis,³ and persistent infection in immunocompromised patients.⁴,⁵ Replication of parvovirus B19 has been demonstrated only in human erythroid progenitor ...

To the Editor: Noordhoek et al. (Dec. 30, 1993, issue)¹ have raised serious questions¹,² about the reliability of the polymerase chain reaction (PCR) for the direct detection of Mycobacterium tuberculosis in clinical specimens. Nevertheless, commercial ...

“The history of obstetrics and gynecology has been written in painting, pottery, parchment, paper, and plaster, rock drawings, wood carvings, coins, tapestries, mosaics, gravestones, and sculpture,” writes Harold Speert, and indeed his new book reproduces ...

The history of cardiology unfolds in this ambitious textbook as a series of parallel concepts, presented in six sections. This approach avoids the problem of chronological medical histories, in which each major figure influences many different areas and ...

In these busy clinical times, a quick, readily applicable remedy for a problem is appealing. Although Arrhythmias provides such solutions, the book is very much more; it is an authoritative, clearly written presentation of the common arrhythmias and some ...

In reviewing this CD-ROM devoted to laparoscopic hernia repair, we are actually evaluating how a new didactic tool deals with a newly developed therapeutic method. This CD-ROM designed by Dr. Rosser enables the user to listen to short lectures about ...

Reading the preface to Laparoscopic Surgery leads one to expect a textbook of laparoscopic surgery with a solid historical perspective. Its review of the evolution of and revolutions in surgical thought since 1543 provides an excellent background for ...

An Anatomy Lesson Clinical Problem-Solving, N Engl J Med 1994:331;318-320.. On page 320, in line 3 of the left-hand column, the phrase should have read, “medial deviation of the ureters,” not “medical deviation,” as printed. We regret the error.

Estrogen Resistance Caused by a Mutation in the Estrogen-Receptor Gene in a Man Original Article, N Engl J Med 1994:331;1056-1061.. On page 1058, in Table 1, the normal range for sex hormone–binding globulin should have been listed as 6 to 44 nmol per ...