In prospective cohort studies, conducted predominantly among men, light-to-moderate drinkers of alcoholic beverages have been found to have lower total mortality rates than either nondrinkers or heavier drinkers.¹–¹⁴ This reduced mortality is due largely ...

Diabetic nephropathy is the chief cause of morbidity and premature mortality in patients with insulin-dependent diabetes mellitus (IDDM).¹,² This complication is first manifested as an increase in urinary albumin excretion (microalbuminuria), which ...

The efficacy of therapies for hepatocellular carcinoma is poor.¹,² Hepatocellular carcinoma is a hypervascular tumor.³ Hepatic intraarterial injection of antitumor agents, performed to increase the local concentration of drugs and reduce systemic side ...

Physicians face a clinical dilemma in deciding whether to administer measles vaccines to patients who are allergic to eggs, because of concern about anaphylaxis in response to the vaccines, which contain live attenuated virus prepared in chick-embryo ...

Figure 1. A 26-year-old man admitted to the hospital because he had had headache and vomiting for two months had papilledema but otherwise normal results on neurologic examination. Magnetic resonance imaging of the brain showed noncommunicating ...

During the past two decades, cardiovascular ultrasonography has benefited from technical innovations that have allowed it to become a cornerstone of the modern diagnosis of cardiac disease. Transesophageal echocardiography (TEE) is one of the more recent ...

The study of Streptococcus pneumoniae has led to many insights into the pathogenesis of bacterial infections. The importance of the polysaccharide capsule of the organism in determining its virulence was indicated by studies of the protective role of ...

Presentation of Case

A 12-year-old boy was admitted to the hospital because of an obstructive right nasal mass.

The patient had been in excellent health until two years earlier, when he began to have right nasal obstruction that gradually worsened. ...

Most physicians accept that hyperglycemia makes an important contribution to the complications of diabetes mellitus involving small and large vessels, but whether hyperglycemia alone is sufficient to explain diabetic vascular disease remains ...

Hepatocellular carcinoma is one of the most common malignant tumors in the world. It is a major cause of death from cancer in eastern Asia, especially China, Japan, Taiwan, Singapore, and Korea, and sub-Saharan Africa, particularly Zimbabwe, Ethiopia, and ...

The Food and Drug Administration (FDA) in the United States is now considering whether to license diagnostic kits that would make possible testing and counseling for human immunodeficiency virus (HIV) infection in the privacy of a person's own home. The ...

To the Editor: The article by Rossing et al. (Sept. 22 issue)¹ may have generated undue anxiety in many women undergoing treatment for infertility. Although this study does prompt some interesting hypotheses about the future risks of ovarian cancer in ...

To the Editor: It is unfortunate that Scognamiglio et al. (Sept. 15 issue)¹ chose to use digoxin instead of placebo to study the effects of nifedipine in asymptomatic patients with chronic, severe aortic regurgitation. Almost two decades since the short-...

To the Editor: The article by Jollis et al. (Dec. 15 issue)¹ concerning the relation between the annual volume of percutaneous transluminal coronary angioplasty (PTCA) procedures and mortality is incomplete and misleading. Data on Medicare admissions for ...

To the Editor: Since we found evidence of a threshold for the effect of hyperglycemia on the risk of microalbuminuria in patients with insulin-dependent diabetes mellitus (IDDM),¹ we used published data to examine whether there was a similar pattern for ...

To the Editor: In the November 24 issue of the Journal, ¹ the legend below the elegant scanning electron micrograph of Mycoplasma pneumoniae states that the organism is “probably the most common cause of community-acquired pneumonia.” This statement, ...

To the Editor: Solomon et al. (Nov. 3 issue)¹ report their experience as three rheumatologists “who have examined and evaluated a combined total of more than 3000 symptomatic women with silicone breast implants.” Their letter deserves further scrutiny. ...

The Food and Drug Administration is considering whether or not to approve diagnostic kits for infection with the human immunodeficiency virus (HIV) that would allow blood collection at home. A person would use a lance provided in the kit to obtain blood ...

Hamer and Copeland tell a good story. Their book describes how Hamer and his colleagues searched for and found evidence of genetic linkage in male homosexuality. Their finding of a correlation between homosexual orientation and the inheritance of ...

The definition of normal sexual function continues to defy medical professionals and talk-show hosts alike, but recent investigation into the pathophysiology of sex has brought a wealth of scientific and clinical information to this emotionally charged ...

You will find sex and drugs in this book, but no rock-and-roll. Rather, the two areas of concern are the unintended effects medications may have on sexual behavior or function and the therapeutic drugs that may find application in the management of sexual ...

Michael Morrisey presents a lucid evaluation of cost shifting, especially in hospital and physician markets, within a classic microeconomic framework. He tackles three fundamental questions: Do providers engage in price discrimination among payers (static ...

An Orally Active Iron Chelator Editorial, N Engl J Med 1995:332;953-954.. On page 953, the sentence that begins in line 24 of the right-hand column should have read, “It [deferiprone] dissociates from iron when its concentration in body fluids falls to ...

Low Power and Striking Results — A Surprise but Not a Paradox Editorial, N Engl J Med 1995:332;1091-1092.. On page 1092, the sentence that begins in the first line of the right-hand column should have read, “Even worse, post hoc consideration of ...