Combination chemotherapy can cure about 45 percent of patients with disseminated intermediate-grade or high-grade non-Hodgkin's lymphoma.¹ Several institutions have reported that aggressive regimens of chemotherapy containing six to eight drugs gave ...

Renal-transplant recipients who receive immunosuppressive therapy have an increased risk of premalignant skin keratoses and skin cancer,¹,² and aggressive cancer occurs 20 to 30 years earlier, on average, in transplant recipients than in subjects who do ...

Familial hypertrophic cardiomyopathy is clinically variable and genetically heterogeneous. The extent and pattern of ventricular hypertrophy and the prognosis for affected persons, particularly the risk of sudden death, vary markedly.¹,² Hypertrophic ...

Infection with the hepatitis B virus (HBV) may result in a number of conditions ranging from asymptomatic persistent carriage to fulminant hepatitis with liver failure. Most infected people have acute hepatitis during which the virus is eliminated. About ...

Figure 1. Abdominal arteriography was performed in a 21-year-old drug abuser who presented with rapidly progressive renal failure. During the previous two months she had had fever and diffuse abdominal pain and had lost 12 kg in weight. The recent onset ...

The decades-long decline in the incidence of tuberculosis in the United States was reversed during the late 1980s. The resurgence continued into the current decade, and despite a 5.1 percent relative decline from 1992 to 1993, the number of reported cases ...

Coccidioidomycosis has been recognized as a distinct disease since 1892 and as a fungal infection since 1900. A recent epidemic of coccidioidomycosis in California¹ and the possibility of this infection's occurrence in association with human ...

Presentation of Case

A 59-year-old man was admitted to the hospital because of possible pneumonia and acute renal failure.

He had a 17-year history of non-insulin-dependent diabetes mellitus that had been managed in recent years with glyburide, with ...

In this issue of the Journal, Verdonck et al.¹ report on a study that, as they planned it, was barely large enough to detect a massive advantage for a controversial and expensive therapy. Moreover, the way they calculated the size of their sample was too ...

Infection with hepatitis B virus (HBV) results in a broad spectrum of liver disease, ranging from subclinical infection to acute, self-limited hepatitis and fatal, fulminant hepatitis. Exposure to HBV, particularly when it occurs early in life, may also ...

This issue of the Journal contains two articles that bear on the status of tuberculosis in the United States. One is a report from the Centers for Disease Control and Prevention (CDC) on tuberculosis in foreign-born persons,¹ and the other is a Sounding ...

In November 1994, California voters approved Proposition 187, which requires publicly funded health care facilities to deny care to illegal immigrants and to report them to government officials.¹ Supporters argued that “an invasion of illegal aliens” is ...

To the Editor: You suggest (Jan. 5 issue)¹ a larger role for the computer in the future of medicine. If we observe the uses of computers in other areas of our society, we must wonder this: Are you a prophetic herald telling of the end of medicine as we ...

To the Editor: The prospective study by Rex and colleagues (Nov. 17 issue)¹ comparing amphotericin B with fluconazole for the treatment of candidemia concludes that the two treatments are equally effective. This opinion is echoed and endorsed in the ...

To the Editor: The comprehensive program in Finland described by Peltola et al. (Nov. 24 issue)¹ shows what can be achieved when a two-dose strategy of immunization with measles–mumps–rubella (MMR) vaccine is fully implemented. As discussed in the report ...

To the Editor: Between June 1 and November 1, 1994, as part of an investigation of an outbreak of rubeola (measles), the Alaska State Health Department studied 57 persons with febrile illness accompanied by a rash. Efforts were made to obtain serum ...

To the Editor: The commentary in the Clinical Problem-Solving article on recurrent pulmonary emboli (Dec. 1 issue)¹ states that there have been no controlled trials of the placement of inferior-vena-caval filters to treat thromboembolism and includes the ...

To the Editor: Preterm birth has been reported to occur shortly after the appearance of substantial amounts of fetal fibronectin in vaginal and cervical secretions.¹,² Fetal fibronectin, a component of the extracellular matrix of fetal membranes, leaks ...

To the Editor: Eosinophilic meningitis caused by Angiostrongylus cantonensis is widespread in the Pacific basin and has been reported in Cuba, Réunion, and the Ivory Coast.¹ To our knowledge, however, no human infection with A. cantonensis has been ...

Imagine a global emergency in the form of a reemerging disease that is infectious; often fatal; increasingly resistant to antimicrobial agents; associated with drug use, AIDS, and alcohol abuse; common among immigrants and inner-city homeless people; and ...