Although the causes of colorectal cancer are incompletely understood, dietary factors appear to be important¹–³. Rates of colorectal cancer are lowest in populations whose diets typically are rich in vegetables and fruits¹. In studies of individual ...

Marfan's syndrome is an autosomal dominant disorder of connective tissue that is characterized by ocular, skeletal, and cardiovascular manifestations. It is estimated to have a prevalence of 1 per 10,000 people, and at least 25 percent of the cases occur ...

Langerhans'-cell histiocytosis (LCH) encompasses several disorders previously known as histiocytosis X, Letterer-Siwe disease, Hand-Schuller-Christian syndrome, eosinophilic granuloma of bone, and self-healing reticulohistiocytosis¹,². The clinical ...

Human infection with cryptosporidium was first documented in 1976¹,². Since that time, cryptosporidium has been recognized as a cause of gastrointestinal illness in both immunocompetent³–⁶ and immunodeficient people⁶,⁷. Infection with cryptosporidium ...

Figure 1. Malignant Melanoma.

There are several recognized variants of malignant melanoma. Panel A depicts a superficial spreading melanoma of the trunk, the type most commonly seen in fair-skinned patients. Panel B shows a lentigo maligna melanoma of the ...

Since 1985 the incidence of tuberculosis in the United States has increased,¹,² and nosocomial transmission has occurred³–⁵. Multidrug-resistant Mycobacterium tuberculosis has become a problem causing high mortality among persons infected with human ...

Thyroxine therapy is given to replace thyroid hormone secretion when it is deficient (hypothyroidism) and also in certain circumstances when suppression of thyrotropin secretion is considered to be of value, such as in patients with thyroid carcinoma. It ...

Presentation of Case

A 51-year-old man was admitted to the hospital because of a nonhealing finger lesion with regional lymphadenopathy.

The patient had been well until one month earlier, when a splinter abraded the dorsal aspect of the proximal ...

Americans have become increasingly avid for news of clinical research that they feel will improve their health or extend their lives. This is particularly true of research about diet or lifestyle. To many Americans, as Fitzgerald points out elsewhere in ...

Human DNA contains many sequences of nucleotides that occur repeatedly from a few to many thousand times within the genome. Nonrepeated, or unique, sequences are, of course, each represented twice -- once on each of a pair of chromosomes. Repeated ...

As a society and as individuals, we Americans are preoccupied with risks, particularly risks to life. From AIDS to cancer to heart disease, from Alar to asbestos to benzene, from eating to drinking to smoking -- we worry about all the risks of living. We ...

There has recently been much in both lay and medical literature on the promotion of healthy lifestyles. Once upon a time people did not have lifestyles; they had lives. Those lives were filled with work and play, battle and respite, excitement and boredom,...

To the Editor: The truth often hurts. Being a medical oncologist, I had pain that reached a score of 10 on reading the article by Cleeland and colleagues (March 3 issue)¹ on the inadequate management of pain in outpatients with cancer. Like many medical ...

To the Editor: The article by Welch et al. (March 3 issue)¹ on physician profiling describes that method well but also illustrates its shortcomings. Adjustment for case mix is the Achilles' heel of physician profiling. All physicians know how flimsy the ...

To the Editor: We write regarding the article (Nov. 18 issue)¹ reporting the results of a multicenter clinical trial that appeared to demonstrate the efficacy of immune globulin with a high titer of antibodies against respiratory syncytial virus (RSV ...

To the Editor: We report two cases of neurocardiogenic syncope in a family. A 19-year-old college student was evaluated for abrupt loss of consciousness which had occurred approximately twice each year since the age of 12. Syncopal episodes were ...

To the Editor: Dr. Spigelman's chest roentgenogram of an 11-year-old girl, entitled “Situs Inversus” (March 3 issue),¹ is most likely an example of situs ambiguus and polysplenia syndrome. Although the aortic arch is right-sided, which would be ...

To the Editor: I share Meador's concern (Feb. 10 issue) about the extinction of well people¹. This is not, however, a recent phenomenon.

In 1923, the French writer Jules Romains addressed this issue in his comedy, “Knock, ou le Triomphe de la Medecine.”² ...

The 14 papers in this book, originally presented at the Wellcome Institute for the History of Medicine in 1987, deal with the ways human senses are involved in medical diagnosis. Based mostly on British sources, they rely on primary printed and manuscript ...

Although books of historical interest are not often the subject of reviews in the Journal, it is appropriate that this book by Gertler and White be recognized in this way. This book, published 40 years ago, marked a turning point in the history of ...

This comprehensive and up-to-date textbook on aortic surgery begins with a remarkable tribute and dedication to E. Stanley Crawford, M.D., one of this era's greatest vascular surgeons. He set the standard for surgery on complex and thoracoabdominal ...

Webster's Third New International Dictionary defines “atlas” as a “collection of tables, charts and plates.” Such items form the basis of this book, for which the primary editors recruited 3 associates and 39 other distinguished contributors. It covers ...

Based on a symposium on chronic fatigue at the annual meeting of the American Psychiatric Association, this short book provides an excellent review of the literature on chronic fatigue and related immunodeficiency syndromes. As a psychiatrist with a ...

Postoperative neurologic and psychological disturbances have been a prominent cause of morbidity in patients undergoing heart surgery since the earliest use of cardiopulmonary bypass in 1955. This collection of 22 clinical essays elucidates the nature and ...

c-erbB-2 Expression and Response to Adjuvant Therapy in Women with Node-Positive Early Breast Cancer Original Article, N Engl J Med 1994:330;1260-1266.. In Table 4, on page 1264, the 95 percent confidence interval for overall survival for the variable “c-...

Book Review of The Turning Point: How Men of Conscience Brought About Major Change in the Care of America's Mentally Ill Book Review, N Engl J Med 1994:330;1546-1547.. On page 1547, in the right-hand column, line 14, the reference should have been to “the ...