Familial clustering of colorectal cancer is generally believed to occur even when the cases are not part of a defined genetic syndrome. At least 12 retrospective studies have suggested that a history of colorectal cancer in a first-degree relative (a ...

Analgesic nephropathy was first described in the 1950s.¹ Phenacetin was subsequently identified as the chief culprit and was withdrawn from the market. Evidence of the nephrotoxicity of other analgesic drugs -- acetaminophen, aspirin, and other ...

Juvenile chronic myelogenous leukemia (CML) is a rare leukemia of infants and young children characterized by a proliferation of myelocytes in peripheral blood and other tissues. A number of clinical¹–³ and laboratory⁴–⁷ features, including the absence of ...

Hydrocolonic ultrasonography -- abdominal ultrasonography in conjunction with the retrograde instillation of water into the colon -- has been advocated as an alternative to colonoscopy for detecting colorectal polyps and cancer¹,². Hydrocolonic ...

Although decreases in regional cerebral blood flow are known to occur in relation to migraine headache, the pattern of the alterations in blood flow has not been precisely delineated. Olesen et al. have described a series of patients who had migraine ...

Figure 1. California Bigfoot.

An electron micrograph shows a neutrophilic leukocyte from an acute bacterial inflammatory reaction in the peritoneal cavity of a rabbit. Two segments of the nucleus can be seen, as well as a cytoplasm full of granules that ...

Colon cancer is one of the most frequent cancers in men and women in the United States.¹ There is a 6 percent lifetime risk of colon cancer in the general population.¹ Approximately 160,000 new cases arise every year, and despite advances in detection and ...

Presentation of Case

A 47-year-old man with relapsed acute myelogenous leukemia was admitted to the hospital for an allogeneic bone marrow transplantation.

The patient had been well until 13 months earlier, when lymphadenopathy developed abruptly and he ...

Chronic tubulointerstitial nephritis and nephritis of unknown origin account for 15 to 30 percent of the cases of end-stage renal disease (ESRD) in the United States and Europe. A substantial but as yet undetermined proportion of these cases may be due to ...

Until the 1988 classification of headaches by the International Headache Society, the various headache disorders were poorly defined, and migraine and tension-type headache were often viewed as part of a continuum.¹ When the society's strict diagnostic ...

To the Editor: I read with sadness the editorial by Dr. Rosenfield (Aug. 4 issue)¹ on second-trimester abortion. I wish to address one of the problems he cites: “Finally, there is a major problem in the United States with regard to the availability of ...

To the Editor: In their otherwise excellent article (Aug. 4 issue),¹ Stubblefield and Grimes mention the means of emptying the uterus in the case of a retained fetus from a midtrimester abortion. Unquestionably, as they state, an “experienced ...

To the Editor: De Vincenzi (Aug. 11 issue)¹ concludes that consistent use of condoms is highly effective in preventing heterosexual transmission of the human immunodeficiency virus (HIV). However, the data analysis is flawed. First, the use of person-...

To the Editor: Suthanthiran and Strom (Aug. 11 issue)¹ “discourage the use of organs from donors seropositive for the hepatitis C virus [HCV] for grafting in recipients who are seronegative for the virus.” In the setting of renal transplantation, in ...

To the Editor: Greenberg et al. (July 21 issue)¹ report negative results when three antioxidant vitamins (beta carotene, vitamin C, and vitamin E) were given over a four-year period to test their efficacy in preventing colorectal adenoma, a surrogate ...

To the Editor: The article by Dr. Brown (Oct. 20 issue)¹ highlights the studies that my colleagues and I have performed with a transgenic model of human motor neuron disease.² Our experiments built on the studies of Dr. Brown and other members of a ...

When I was preparing for my fellowship in hematology I bought two books about the blood: Maxwell M. Wintrobe's Clinical Hematology (Philadelphia: Lea & Febiger) and The Hemorrhagic Disorders by Mario Stefanini and William Dameshek. The Wintrobe book, ...

Some organs of the body, such as the appendix, are not essential for life. The spleen is also dispensable, but unlike the appendix it has important functions. A prominent activity of the spleen is to cull damaged, worn-out, or potentially dangerous cells ...

This new textbook blends coverage of blood banking, transfusion medicine, and hematology. The usual technical details relevant to the provision of blood and blood products are distinctly absent. Instead, an impressive group of contributors has created a ...

The intricacies of biologic systems are unraveled in fits and starts. Rapid advances in knowledge create new models and paradigms that form the basis of subsequent investigation. Iron Metabolism in Health and Disease eloquently captures the current state ...