The care of patients with trauma places a large burden on the health care system¹,². Trauma is the leading cause of death in people under the age of 40 years, and the care of patients with trauma accounts for more hospital days per year than the care of ...

Non-A, non-B hepatitis has been reported after substitution therapy with immune globulin in several patients with primary hypogammaglobulinemia¹–⁶. In Scandinavia, one intravenous immune globulin product in particular (Gammonativ, KabiVitrum, Stockholm, ...

In early 1946, a previously unreported febrile illness was recognized in New York City¹,². The disease was named rickettsialpox because of a clinical resemblance to chickenpox and because an organism with characteristics consistent with rickettsiae was ...

Osteopenia is common in young women with hypogonadism caused by hyperprolactinemia, excessive exercise, anorexia nervosa, or hypothalamic amenorrhea¹–³. It also occurs in women with endometriosis or uterine leiomyomas who are treated with an analogue of ...

Figure 1. Vasculitis and Cryoglobulinemia Related to Hepatitis C.

A 51-year-old woman with chronic hepatitis C virus (HCV) infection and type II cryoglobulinemia reported fatigue, pain in her ankles, and recurrent crops of superficial vasculitic lesions ...

Previous studies have found an inverse relation between the number of selected procedures performed at a hospital (volume) and mortality after the procedure¹–³. Hospitals that perform more procedures -- such as coronary-artery bypass grafting (CABG), ...

Credit for fundamental studies leading to our current understanding of deep-vein thrombosis should be given to Bauer, who used phlebography to diagnose deep-vein thrombosis complicating fractures of the tibia,¹ and to Sevitt and Gallagher for their ...

Presentation of Case

A 38-year-old woman was evaluated in the clinic because of severe rheumatoid arthritis and a new left pleural effusion.

The patient was a hairdresser. She had had seropositive rheumatoid arthritis for 8 1/2 years. On repeated tests ...

Until the report earlier this year of more than 100 cases of hepatitis C virus infection in 24 states,¹ most U.S. physicians believed that intravenous immune globulin did not pose the risks of transmitting viral infections that have been associated with ...

The article by Kass et al.¹ in this issue of the Journal is an appropriate reminder that rickettsialpox, like rickettsial diseases in general, is still with us. The rickettsialpox diagnosed in 13 patients at one hospital in New York City undoubtedly ...

Effective resuscitation requires physicians and others with the training and skills to perform difficult procedures under stressful conditions, yet there can be no physicians with the necessary experience unless they first have opportunities to learn and ...

To the Editor: The Sounding Board article “Regulating Physician-Assisted Death” by Miller et al. (July 14 issue)¹ nicely reveals, though unwittingly, what a charade such regulation would quickly become. First, the article fails to acknowledge the most ...

To the Editor: Adal et al. (July 21 issue)¹ demonstrate that at the University of Virginia Hospital, where the incidence of tuberculosis is low, the infection controls already instituted may be sufficient and the cost of adding respirators with high-...

To the Editor: I greatly enjoyed reading “An Anatomy Lesson” by Dr. Duffy (Aug. 4 issue).¹ As a resident physician I appreciate and learn a great deal from such practical clinical vignettes.

After outlining the importance of the retroperitoneal lymphatic ...

To the Editor: Reading Dr. Fitzgerald's article, “The Tyranny of Health” (July 21 issue),¹ reminded me of a comment a patient once made to me. After I had berated the patient for his obvious failure to comply with my recommendations to correct his “...

To the Editor: Lead poisoning in children is endemic in many areas of the United States. Because of inadequate primary preventive measures, health providers must rely on secondary preventive measures, such as screening of children who have close contact ...

Elizabeth Lunbeck has written an ambitious, detailed, and very interesting book about early 20th-century American psychiatry. Using the tools of a historian and the skills of a talented writer, she presents a history of the discipline in a period of ...

The variety of ways in which seizures are expressed has made their diagnosis difficult, particularly because the patient cannot describe either the nature or the duration of events. Reliance on electroencephalographic (EEG) patterns can lead to both false ...

General-reference, multiauthored textbooks are ambitious undertakings. They require ardent editorial discipline to keep the book focused on the overall theme. In this book, the editors' purpose appears to have been twofold. They wanted to concentrate on ...

The study of sexual dysfunction has for years suffered from a lack of well-controlled, scientific studies and objective data. In the past few years, insightful physicians and scientists have entered the field and added a tremendous amount to our ...

Medicine Unbound is the third volume in the series Emerging Issues in Biomedical Policy, which examines the policy issues raised by the rapid advances in medical technology. This book is a collection of essays by ethicists, scientists, physicians, and ...

Case Records of the Massachusetts General Hospital (Case 32-1994) Case Records of the Massachusetts General Hospital, N Engl J Med 1994:331;528-535.. On page 533, the phrase beginning in line 19 of the lefthand column should have read, “destruction of the ...

Ethical Challenges Posed by Zidovudine Treatment to Reduce Vertical Transmission of HIV Editorial, N Engl J Med 1994:331;1223-1225.. On page 1225, the first reference should have read as follows:

1. Connor EM, Sperling RS, Gelber R, et al. Reduction of ...