Febrile, nonhemolytic transfusion reactions are the most frequent adverse reactions to blood products. The risk of these reactions is highest with platelets; they occur in 5 to 30 percent of platelet transfusions, depending on the type of product¹–³. Most ...

Growth and development are usually adversely affected in children and adolescents with Cushing's syndrome¹–⁷. The syndrome may be caused by excessive secretion of corticotropin by the pituitary gland or an ectopic corticotropin-secreting tumor, or by ...

Respiratory disease in patients with cystic fibrosis is characterized by airway obstruction caused by the accumulation of thick, purulent secretions, recurrent exacerbations of respiratory symptoms, and progressive deterioration of lung function¹. In such ...

In recent years, overcrowding in correctional facilities has reached crisis proportions, especially in our nation's jails, which operate at more than 200 percent of their capacity¹. There are few data on the consequences of this overcrowding with respect ...

Figure 1. Owl's-Eye Cells.

The photomicrograph shows a section of kidney taken at autopsy from a three-month-old boy who died of disseminated cytomegalovirus infection contracted in utero. A single periglomerular renal tubule contains large, intranuclear ...

Requirements for cost sharing by patients and limitations on coverage for primary medical care are popular cost-containment strategies in the United States and other countries¹–³; they may become more prevalent as a result of future health insurance ...

In recent years, the concept of acid-reflux disorders has been broadened to include not only the effects of gastroesophageal reflux on the esophageal mucosa but also the role of acid reflux in laryngeal and pulmonary symptoms. This review discusses the ...

Presentation of Case

A 41-year-old woman was transferred to this hospital because of thrombocytopenia, anemia, and changed mental status.

There was a history of treated hypothyroidism, well-controlled hypertension, and mild anemia of several years' ...

Concern about cost now dominates many decisions about the use of drugs and other therapeutic interventions. Increasingly, such decisions are being influenced by published economic analyses that relate the effectiveness of treatments and their associated ...

Febrile, nonhemolytic reactions have been a clinical problem since the beginning of transfusion therapy. In the 1960s, antileukocyte antibodies were identified as a cause of these reactions, an observation that led to the discovery of the HLA antigens. ...

Thirty years ago, a treatment program for patients with cystic fibrosis was laid out that emphasized combating pulmonary infection, improving bronchial drainage, and attending to nutrition¹. This symptomatic approach, devised with no specific knowledge of ...

Editorials in medical journals are typically dispassionate, carefully written critiques of new research, often with just the right amount of background to place matters of uncertainty in context. The statements made in an editorial imply an informed, ...

To the Editor: Dr. Brennan's argument for better disclosure of collaboration between pharmaceutical companies and academic medicine (see the Sounding Board article elsewhere in this issue) merits serious consideration. However, the portrayal of the part ...

To the Editor: The report by Maier et al. (April 28 issue)¹ on the effect of epoetin beta (recombinant human erythropoietin) in very-low-birth-weight infants provides important new data on the efficacy and safety of the agent in this age group. However, ...

To the Editor: The recent article by Fanaroff et al. on the use of intravenous immune globulin to reduce nosocomial infections in very-low-birth-weight infants (April 21 issue)¹ is the largest published study of the use of this intervention in this ...

To the Editor: We share the concern expressed by Dr. Tomasz and his colleagues (April 28 issue) in the report on multiple-antibiotic-resistant pathogenic bacteria,¹ particularly with regard to tuberculosis. However, we want to clarify an apparent ...

To the Editor: Papadopoulos et al. (April 28 issue)¹ report complete remission in five patients who received unmanipulated donor T cells as therapy for Epstein-Barr virus (EBV)-associated lymphoproliferation after allogeneic bone marrow transplantation. ...

To the Editor: We believe that hepatic atrial infusion, new drugs, and biochemical modulation deserve more attention than they received in Dr. Moertel's review of chemotherapy for colorectal cancer (April 21 issue)¹. With respect to hepatic arterial ...

To the Editor: Kinch and Ryan (April 28 issue) present an excellent review of the pathogenesis, pathophysiology, diagnosis, complications, and treatment of the right ventricular infarction that commonly accompanies inferior myocardial infarction¹. I ...

To the Editor: Haddow et al. (April 21 issue)¹ report that among pregnant women 35 years of age or older, screening serum for three substances (alpha-fetoprotein, human chorionic gonadotropin, and estriol) can identify 89 percent of fetuses with Down's ...

To the Editor: Molecular biologic techniques for the detection of Y-chromosome sequences have illustrated the limitations of cytogenetic analysis in the evaluation of patients with Turner's syndrome¹,². In previous studies using Southern blot analysis of ...

To the Editor: Orah and Richard Platt's entertaining review of The Poisonous Pen of Agatha Christie (April 14 issue)¹ contains a regrettable error regarding the solubility of arsenic trioxide. The statement is made that this poison, although minimally ...

This is James V. Neel's account of his career in genetics. It deals not with the personalities of the author and his associates but with the results of his research and theirs, which make up a major part of what we know about human population genetics. ...

The ability to diagnose genetic diseases early in pregnancy has already demonstrated the power of remarkable forms of technology and stimulated innumerable ethical debates. Now the diagnosis of genetic disease even before implantation provides new ...

On October 1, 1987, a South African woman gave birth to her grandchildren. Her daughter and son-in-law had undergone in vitro fertilization procedures, and she had served as the surrogate mother to triplets. Two weeks later, the South African legislature ...

The literature of the history of medicine contains relatively few serious studies of the formation of ethical standards for medical practice. Consequently, this collection of essays comes as a welcome addition. This book, the first of two planned volumes, ...

Max Charlesworth, the distinguished Australian philosopher and bioethicist, has written a lucid and instructive analysis of the concept of autonomy in medical ethics and health care. He unabashedly tackles three controversial areas: decisions at the end ...

More on the GUSTO Trial Correspondence, N Engl J Med 1994:331;277-278.. On page 278, in Figure 1, in the row for >6 hours to thrombolytic therapy, the values should have read, “4, 9.0, and 8.9,” not “4, 8.9, and 9.1,” as printed.

Retinal-Artery Embolism after Directional Coronary Atherectomy Correspondence, N Engl J Med 1994:331;278-279.. On page 278, in line 5 of the right-hand column, the sentence beginning “In this procedure” should be deleted.