The anemia of prematurity is commonly associated with low reticulocyte counts and deficient erythropoietin production¹,². In addition, diagnostic tests cause blood loss,³ which may add up to an infant's total blood volume within 28 days⁴. Since anemia may ...

From 1953 to 1984, the incidence of tuberculosis in the United States declined progressively. In 1985, the trend was reversed, with an increasing number of excess cases, as compared with those predicted on the basis of the previous downward trend, ...

In marrow-transplant recipients, lymphoproliferative disorders associated with Epstein-Barr virus (EBV) usually present as malignant B-cell lymphomas of donor origin, which may be either polyclonal or monoclonal¹–⁴. The latter have a rapidly progressive, ...

Parvovirus B19, the only known pathogenic human parvovirus, causes fifth disease, or erythema infectiosum, a mild childhood illness characterized by rash¹. In persons with underlying hemolysis, especially sickle cell disease and hereditary spherocytosis, ...

Figure 1. Progressive Multifocal Leukoencephalopathy.

Magnetic resonance images of the brain were obtained in a 40-year-old man with the acquired immunodeficiency syndrome who had a six-week history of decreased memory and visual impairment. The changes ...

From mild disease to multiorgan failure and sepsis, acute pancreatitis is a disorder that has numerous causes, an obscure pathogenesis, few effective remedies, and an often unpredictable outcome. In 1925, Moynihan aptly described the dramatic nature of ...

The description of right ventricular myocardial infarction appeared more than 60 years ago,¹ yet for decades it was not considered an important clinical entity, in large part because of studies in animals in which experimentally induced isolated right ...

Presentation of Case

A 38-year-old man with the acquired immunodeficiency syndrome (AIDS) was admitted to the hospital because of abdominal pain and bleeding from the rectum.

Two-and-a-half years earlier Pneumocystis carinii pneumonia had developed, and ...

Premature infants weighing less than 1300 g receive multiple red-cell transfusions, primarily because of blood loss from repeated blood sampling to monitor respiratory disease and because of the anemia of prematurity -- a condition associated with low ...

Several reports in this issue of the Journal deal with the potentially disastrous situation of antibiotic resistance¹–³. The current antibiotic-resistance crisis differs from those of the past because several different organisms are involved and because ...

The Epstein-Barr virus (EBV), a ubiquitous herpesvirus estimated to infect 90 percent of the world's population,¹ has been linked to a growing number of diseases, especially in immunocompromised hosts. The first ties between neoplastic disease and EBV ...

To the Editor: A methodologic problem besets the evaluation of the appropriate health care for very premature infants -- namely, the unaccounted-for heterogeneity in obstetrical and neonatal care received by these fetuses and infants. Unless this factor ...

To the Editor: Dr. Todd (Dec. 2 issue)¹ attempts to convince us that valid reform of our health care system can occur only if “something” is done about the “malpractice `mess.”' He proceeds to detail how the “current atmosphere” perniciously affects the ...

To the Editor: Because of the possibility of residual confounding, relative risks of the order of 1.3 or less, as reported by Dockery et al. in their study of air pollution and mortality (Dec. 9 issue),¹ are difficult to interpret in epidemiologic ...

To the Editor: The report by Beck et al. (Dec. 9 issue)¹ on the effect of corticosteroids on the subsequent development of multiple sclerosis in patients with optic neuritis comes to some stupendous and puzzling conclusions about the natural course of ...

To the Editor: In their study of patients with iron-deficiency anemia, Rockey and Cello (Dec. 2 issue)¹ made no attempt to exclude celiac disease as a potential cause, and they suggest that this possibility is unlikely. This is surprising given the well-...

To the Editor: Fluoroquinolones have been shown to decrease the frequency of gram-negative infections in patients with neutropenia¹,². Although fluoroquinolone-resistant mutations seem to occur at low rates in Enterobacteriaceae,³ overuse of these ...

To the Editor: An outbreak of tuberculosis resistant to rifampin, isoniazid, streptomycin, and ethambutol occurred in our institution¹ in association with conversions among our health care workers after tuberculin skin testing. Sixteen workers entered a ...

To the Editor: Individual studies are seldom large enough to permit assessment of the shape of those dose-response relations between even common exposures and outcomes, such as alcohol intake and myocardial infarction. For example, the confidence ...

Sigmund Freud is widely thought of as the great discoverer of the unconscious and of its role in normal and pathologic mental events. Although Freud's explorations of unconscious processes and his theories about their place in mental experiences have had ...

This book seeks to summarize research on the symptoms of schizophrenia, as opposed to the syndrome of schizophrenia. Such an approach seems very reasonable, since the syndrome is not only difficult to diagnose reliably but also of uncertain validity. ...

This book reflects the enormous and exciting growth in knowledge about personality disorders during the past decade and sets this growth within the context of the dramatic changes that are transforming psychiatry. Its author, Michael Stone, is one of the ...

This major textbook will be a standard reference in medical psychiatry. It is an expanded and revised version of the earlier Principles of Medical Psychiatry, with a change in title that provides a more accurate reflection of the subject than its ...

In the United States today, when a person's behavior deviates sufficiently from the accepted norm to frighten or threaten others and it is determined that the behavior stems from a mental disorder, that person will most likely be placed in an inpatient ...

Last year, a small group of scientists, physicians, and public health experts gathered at Rockefeller University for a one-day workshop to discuss the accelerating spread of bacterial pathogens resistant to antimicrobial agents and whether multiresistant ...

Newer Purine Analogues for the Treatment of Hairy-Cell Leukemia Review Article, N Engl J Med 1994:330;691-697.. In Figure 3, on page 693, the structure for 2'-deoxycoformycin is incorrect. There should be a carbon atom, with an attached hydroxyl group and ...